公开(公告)号：EP2294071A1

公开(公告)日：2011-03-16

申请号：EP09729779.0

申请日：2009-04-08

申请人： N.V. Organon ,  Pharmacopeia, LLC

发明人： ROUGHTON, Andrew Laird ,  HO, Koc-Kan ,  OHLMEYER, Michael ,  DILLER, David ,  NEAGU, Irina ,  KINGSBURY, Celia ,  CHAN, Jui-Hsiang ,  LOMMERSE, Johannes, Petrus, Maria ,  TEERHUIS, Neeltje, Miranda ,  WIJKMANS, Jacobus Cornelis Henricus Maria ,  PLATE, Ralf

IPC分类号： C07D487/04 ,  A61K31/519

CPC分类号： C07D487/04

摘要： The present invention relates to a pyrrolo[2,3-d]pyrimidin-2-yl-amine derivative according to formula (I) wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising one or more of said pyrrolo[2,3-d]pyrimidine-2-ylamine derivatives and to their use in therapy, for instance in the treatment of PKCθ mediated disorders.

公开(公告)号：EP1282615B1

公开(公告)日：2011-10-19

申请号：EP01929361.2

申请日：2001-02-26

申请人： N.V. Organon

发明人： VEENEMAN, Gerrit, Herman ,  TEERHUIS, Neeltje, Miranda

IPC分类号： C07D311/60 ,  A61K31/35 ,  A61P5/30

CPC分类号： C07D311/60

摘要： The invention provides chroman compounds having Formula (1), wherein R1 is (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl, and independently R1 has a cis-orientation in relation to the exocyclic phenyl group at the 2-position of the skeleton; R4 is Hal, CF¿3?, OH or (1C-2C)alkyloxy; R?2, R3, and R5¿ are independently H, Hal, CF¿3?, (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl and prodrugs thereof for the manufacture of a medicine for estrogen-receptor related treatments.