公开(公告)号：EP2857010A4

公开(公告)日：2016-03-09

申请号：EP13796766

申请日：2013-05-28

申请人： NAI INC

发明人： KITA KIYOSHI ,  INAOKA KEN DANIEL ,  SAIMOTO HIROYUKI ,  YAMAMOTO MASAICHI

IPC分类号： A61K31/11 ,  A61K9/08 ,  A61K31/121 ,  A61K31/216 ,  A61K31/222 ,  A61K31/336 ,  A61K31/341 ,  A61K31/351 ,  A61K31/357 ,  A61K47/10 ,  A61P1/04 ,  A61P3/10 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07C47/56 ,  C07C47/565 ,  C07C47/575

CPC分类号： A61K31/341 ,  A61K9/0019 ,  A61K9/1623 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/4866 ,  A61K31/11 ,  A61K31/121 ,  A61K31/216 ,  A61K31/222 ,  A61K31/336 ,  A61K31/351 ,  A61K31/357 ,  A61K47/02 ,  A61K47/12 ,  A61K47/34 ,  C07C47/56 ,  C07C47/565 ,  C07C47/575 ,  C07C49/248 ,  C07C49/255 ,  C07C49/258 ,  C07C69/63 ,  C07C69/738 ,  C07D303/14 ,  C07D303/32 ,  C07D307/20 ,  C07D309/12

摘要： The present invention provides a novel dihydroorotic acid dehydrogenase inhibitor which is applicable to various diseases. When used as an active ingredient, a compound represented by formula (I): (wherein X represents a halogen atom, R 1 represents a hydrogen atom, R 2 represents an alkyl group containing 1 to 7 carbon atoms, R 3 represents -CHO, and R 4 represents -CH 2 -CH=C(CH 3 )-R 0 (wherein R 0 represents an alkyl group containing 1 to 12 carbon atoms which may have a substituent on the terminal carbon and/or on a non-terminal carbon, etc.)), an optical isomer thereof or a pharmaceutically acceptable salt thereof has a high inhibitory effect on dihydroorotic acid dehydrogenase and can be used as an immunosuppressive agent, a therapeutic agent for rheumatism, an anticancer agent, a therapeutic agent for graft rejection, an antiviral agent, an anti- H . pylori agent, a therapeutic agent for diabetes or the like.