公开(公告)号：EP2138158A4

公开(公告)日：2010-08-04

申请号：EP08720753

申请日：2008-02-19

申请人： NAT INST OF ADVANCED IND SCIEN

发明人： IMAMURA TORU ,  KIMURA MIHO ,  KAWANO MITSUKO ,  TSUJINO NOZOMI ,  KURAMOCHI AKIKO ,  ODA YUKO ,  MOTOMURA KAORI ,  SUZUKI MASASHI ,  ASADA MASAHIRO ,  KAMEYAMA AZUSA ,  TOGAYACHI SUMIE ,  OKA SYUICHI

IPC分类号： A61K8/64 ,  A61K8/84 ,  A61K8/97 ,  A61Q9/04 ,  C07K14/435 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/68

CPC分类号： C07K14/43536 ,  A61K8/64 ,  A61Q7/02 ,  G01N33/566 ,  G01N2333/50 ,  G01N2500/10

公开(公告)号：EP2617284A4

公开(公告)日：2014-04-30

申请号：EP11825257

申请日：2011-09-16

申请人： NAT INST OF ADVANCED IND SCIEN

发明人： IMAMURA TORU ,  UEKI MIHO ,  ODA YUKO

IPC分类号： A01K67/027 ,  C12N15/09 ,  G01N33/50

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/03 ,  G01N33/5088 ,  G01N2333/50

公开(公告)号：EP2127674A4

公开(公告)日：2011-04-27

申请号：EP08720756

申请日：2008-02-19

申请人： NAT INST OF ADVANCED IND SCIEN

发明人： IMAMURA TORU ,  KIMURA MIHO ,  KAWANO MITSUKO ,  TSUJINO NOZOMI ,  KURAMOCHI AKIKO ,  ODA YUKO ,  MOTOMURA KAORI ,  SUZUKI MASASHI ,  ASADA MASAHIRO ,  KAMEYAMA AZUSA ,  TOGAYACHI SUMIE ,  OKA SYUICHI

IPC分类号： A61K45/00 ,  A61K8/64 ,  A61K8/97 ,  A61K31/7105 ,  A61K31/711 ,  A61K36/42 ,  A61K38/00 ,  A61K39/395 ,  A61K45/06 ,  A61K48/00 ,  A61P17/14 ,  A61Q7/00

CPC分类号： A61K36/42 ,  A01K2227/105 ,  A61K8/64 ,  A61K8/97 ,  A61K31/7105 ,  A61K31/711 ,  A61K38/1825 ,  A61K45/06 ,  A61K2800/70 ,  A61Q7/00

摘要： It is intended to provide a hair growth promoting agent, hair regrowth promoting agent or therapeutic for alopecia by determining an endogenous factor that inhibits hair growth and screening for substances that inhibit the activity or expression of the endogenous factor. It has been found that FGF18 inhibits hair growth. A method of screening for substances that inhibit the activity of FGF18 or substances that inhibit the expression of FGF18 to thereby obtain candidates for the hair growth promoting agent, hair regrowth promoting agent or therapeutic for alopecia is disclosed. Also disclosed is a hair growth promoting agent, hair regrowth promoting agent or therapeutic for alopecia comprising, as an active ingredient(s), a substance that inhibit the activity of FGF18 and/or a substance that inhibits the expression of FGF18 such as a partial peptide of FGF18 or a Momordica charantia hot water extract.