公开(公告)号：EP1138334A3

公开(公告)日：2002-04-03

申请号：EP01201994.9

申请日：1993-06-07

申请人： NEORX CORPORATION

发明人： AXWORTHY, Donald B. ,  Theodore, Louis J. ,  GUSTAVSON, Linda M. ,  RENO, John M.

IPC分类号： A61K47/48

CPC分类号： C07D495/04 ,  A61K47/54 ,  A61K47/557 ,  A61K47/665 ,  A61K47/68 ,  A61K47/6887 ,  A61K47/6893 ,  A61K47/6898 ,  A61K51/0497 ,  A61K51/1268 ,  A61K2121/00 ,  A61K2123/00 ,  B82Y5/00

摘要： Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for improved radiohalogenation of biotin, as well as related compounds, are described. Also, clearing agents, anti-ligand-targeting moiety conjugates, target cell retention enhancing moieties and additional methods are discussed.