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1.发明公开THERAPEUTIC COMBINATION COMPRISING AN AURORA KINASE INHIBITOR AND AN ANTINEOPLASTIC AGENT 审中-公开与极光激酶抑制剂和抗肿瘤药治疗组合
公开(公告)号：EP2344156A1
公开(公告)日：2011-07-20
申请号：EP09780134.4
申请日：2009-07-03
IPC分类号： A61K31/4162 , A61K45/06 , A61P35/00
CPC分类号： A61K31/4162 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/496 , A61K31/513 , A61K31/555 , A61K31/7068 , A61K45/06 , A61K2300/00
摘要： The present invention provides a therapeutic combination comprising (a) compound 1 of formula (A) as set forth in the specification and (b) one or more antineoplastic agents selected from the group consisting of platinum derivatives, antimetabolite agents, topoisomerase I inhibitors and antimicrotubule agents, wherein the active ingredients are present in each case in free form or in the form of a pharmaceutically acceptable salt or any hydrate thereof.
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2.发明授权
公开(公告)号：EP2344156B1
公开(公告)日：2018-10-17
申请号：EP09780134.4
申请日：2009-07-03
IPC分类号： A61K31/496 , A61K31/513 , A61K31/7068 , A61K31/4745 , A61K31/337 , A61K31/282 , A61P35/00
CPC分类号： A61K31/4162 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/496 , A61K31/513 , A61K31/555 , A61K31/7068 , A61K45/06 , A61K2300/00
摘要： The present invention provides a therapeutic combination comprising (a) compound 1 of formula (A) as set forth in the specification and (b) one or more antineoplastic agents selected from the group consisting of platinum derivatives, antimetabolite agents, topoisomerase I inhibitors and antimicrotubule agents, wherein the active ingredients are present in each case in free form or in the form of a pharmaceutically acceptable salt or any hydrate thereof.
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3.发明公开THERAPEUTIC COMBINATION COMPRISING A PLK1 INHIBITOR AND AN ANTINEOPLASTIC AGENT 有权一个PLK1抑制剂和抗肿瘤的治疗组合
公开(公告)号：EP2435041A1
公开(公告)日：2012-04-04
申请号：EP10723967.5
申请日：2010-05-21
发明人： VALSASINA, Barbara , BERIA, Italo , CIAVOLELLA, Antonella , BALLINARI, Dario , PESENTI, Enrico , MOLL, Juergen
IPC分类号： A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K31/4412 , A61K31/4965 , A61K31/506
CPC分类号： A61K45/06 , A61K31/282 , A61K31/337 , A61K31/4412 , A61K31/4745 , A61K31/4965 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K2300/00
摘要： The present invention provides a combination comprising (a) a compound of formula (I) and (b) one or more antineoplastic agents selected from the group consisting of an antimetabolite agent, analkylating or alkylating-like agent, an intercalating agent, a topoisomerase I or II inhibitor, an antimitotic agent, a kinase inhibitor, a proteasome inhibitor and an antibody inhibiting a growth factor or its receptor, wherein active ingredients of the combination are present in each case in free form or in the form of a pharmaceutically acceptable salt or any hydrate or solvate thereof, useful in the treatment of tumors.
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4.发明授权Therapeutic combination comprising a PLK1 inhibitor and an antineoplastic agent 有权治疗组合aus einem PLK1- Hemmer和einem Antineoplastikum
公开(公告)号：EP2435041B1
公开(公告)日：2016-12-28
申请号：EP10723967.5
申请日：2010-05-21
发明人： VALSASINA, Barbara , BERIA, Italo , CIAVOLELLA, Antonella , BALLINARI, Dario , PESENTI, Enrico , MOLL, Juergen
IPC分类号： A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K31/4412 , A61K31/4965 , A61K31/506
CPC分类号： A61K45/06 , A61K31/282 , A61K31/337 , A61K31/4412 , A61K31/4745 , A61K31/4965 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K2300/00
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5.发明授权1H-THIENO[2,3-C]-PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS 有权-1H-噻吩并[2,3-C] -PYRAZOLVERBINDUNGEN适用作为激酶抑制剂的
公开(公告)号：EP1904503B1
公开(公告)日：2013-11-06
申请号：EP06764123.3
申请日：2006-07-10
发明人： MOLL, Juergen , FANCELLI, Daniele , BANDIERA, Tiziano , QUARTIERI, Francesca , PULICI, Maurizio
IPC分类号： C07D495/04 , A61K31/4162 , A61P35/00
CPC分类号： C07D495/04
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6.发明授权
公开(公告)号：EP2313097B1
公开(公告)日：2013-03-27
申请号：EP09780399.3
申请日：2009-07-09
发明人： PESENTI, Enrico , BALLINARI, Dario , MOLL, Juergen
IPC分类号： A61K31/453 , A61K31/496 , A61K31/506 , A61K38/05 , A61K39/395 , A61K45/06 , A61P35/00
CPC分类号： A61K38/05 , A61K31/453 , A61K31/496 , A61K31/506 , A61K39/39558 , A61K45/06 , A61K2300/00
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7.发明公开
公开(公告)号：EP2313097A2
公开(公告)日：2011-04-27
申请号：EP09780399.3
申请日：2009-07-09
发明人： PESENTI, Enrico , BALLINARI, Dario , MOLL, Juergen
IPC分类号： A61K31/453 , A61K31/496 , A61K31/506 , A61K38/05 , A61K39/395 , A61K45/06 , A61P35/00
CPC分类号： A61K38/05 , A61K31/453 , A61K31/496 , A61K31/506 , A61K39/39558 , A61K45/06 , A61K2300/00
摘要： The present invention provides a combination comprising a compound 1 of formula (A) and one or more antineoplastic agents selected from the group consisting of an antibody inhibiting a growth factor or a receptor of the growth factor, a proteasome inhibitor or a derivative or prodrug thereof, and a kinase inhibitor or a derivative or prodrug thereof useful in the treatment of tumors.
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8.发明公开1H-THIENO[2,3-C]-PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS 有权-1H-噻吩并[2,3-C] -PYRAZOLVERBINDUNGEN适用作为激酶抑制剂的
公开(公告)号：EP1904503A1
公开(公告)日：2008-04-02
申请号：EP06764123.3
申请日：2006-07-10
发明人： MOLL, Juergen , FANCELLI, Daniele , BANDIERA, Tiziano , QUARTIERI, Francesca , PULICI, Maurizio
IPC分类号： C07D495/04 , A61K31/4162 , A61P35/00
CPC分类号： C07D495/04
摘要： There are provided thieno[2,3-c]pyrazole derivatives of formula (I), wherein A is an aryl or heteroaryl ring, on which the substituent -NHZR5 is at the ortho position to the CONH linker; R1 and R2 are the same or different and, independently from each other, represent a hydrogen atom or an organic group; R4 is a hydrogen or halogen atom or an organic group; Z is direct bond, >C=O, or -C(=O)NH-; R5 is hydrogen or an organic group; or isomers, tautomers, carriers, metabolites, prodrugs, and pharmaceutically acceptable salts thereof. A process for their preparation and pharmaceutical compositions comprising them are also disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
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