公开(公告)号：EP1976851A2

公开(公告)日：2008-10-08

申请号：EP07718002.4

申请日：2007-01-17

申请人： NEUROCRINE BIOSCIENCES, INC. ,  Laboratorios Almirall, S.A.

发明人： SLEE, Deborah ,  ZHANG, Xiaohu ,  RUETER, Jaimie K. ,  LIN, Emily ,  CRESPO CRESPO, Maria Isabel ,  CASTRO PALOMINO LARIA, Julio Cesar

IPC分类号： C07D407/14 ,  C07D417/14 ,  A61K31/506 ,  A61P25/16

CPC分类号： C07D405/14 ,  C07D417/14

摘要： Compounds of formula (I), including pharmaceutically acceptable salts, esters, solvates, stereoisomers and prodrugs thereof thereof, wherein R1, R2, R3, R4, R5, X, m and n are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.

公开(公告)号：EP1888565A2

公开(公告)日：2008-02-20

申请号：EP06750082.7

申请日：2006-04-11

申请人： NEUROCRINE BIOSCIENCES, INC. ,  Laboratorios Almirall, S.A.

发明人： SLEE, Deborah ,  LANIER, Marion ,  VONG, Binh, G. ,  CHEN, Yongsheng ,  ZHANG, Xiaohu ,  LIN, Emily ,  MOORJANI, Manisha ,  CASTRO PALOMINO LARIA, Julio, Cesar

IPC分类号： C07D407/14 ,  C07D417/14 ,  C07D401/14 ,  C07D403/04

CPC分类号： C07D405/14 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14

摘要： Compounds of formula (I), including pharmaceutically acceptable salts, esters, solvates and stereoisomers thereof, Rl, R2 and R3 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof as antagonists of adenosine receptors, in particular antagonists of the A2A adenosine receptor subtype.

公开(公告)号：EP1802627B1

公开(公告)日：2012-08-29

申请号：EP05818308.8

申请日：2005-10-19

申请人： SmithKline Beecham (Cork) Limited ,  NEUROCRINE BIOSCIENCES, INC.

发明人： LANIER, Marion ,  LUO, Zhiyong ,  MOORJANI, Manisha ,  TELLEW, John Edward ,  WILLIAMS, John P. ,  ZHANG, Xiaohu

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/00

CPC分类号： C07D487/04

公开(公告)号：EP1465867A1

公开(公告)日：2004-10-13

申请号：EP02800985.0

申请日：2002-10-09

申请人： Neurocrine Biosciences, Inc.

发明人： DYCK, Brian, P. ,  GOODFELLOW, Val ,  PHILLIPS, Teresa ,  PARKER, Jessica ,  ZHANG, Xiaohu ,  CHEN, Chen ,  TRAN, Joe, Anh ,  PONTILLO, Joseph ,  TUCCI, Fabio, C.

IPC分类号： C07D209/42 ,  C07D209/44 ,  C07D211/60 ,  C07D213/38 ,  C07D213/81 ,  C07D213/82 ,  C07D215/54 ,  C07D217/26 ,  C07D277/28 ,  C07D295/18 ,  C07D307/68 ,  C07D333/20 ,  C07D401/12 ,  C07D487/08

CPC分类号： C07D213/81 ,  A61K38/00 ,  C07D209/42 ,  C07D209/44 ,  C07D211/60 ,  C07D213/38 ,  C07D213/82 ,  C07D215/54 ,  C07D217/26 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D277/28 ,  C07D295/185 ,  C07D307/68 ,  C07D333/20 ,  C07D333/24 ,  C07D333/38 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D487/08 ,  C07K5/06139 ,  C07K5/06191

摘要： Compounds which function as melanocortin receptor ligands and having utility in the treatment of melanocortin receptor-based disorders, and may be used to treat disorders or illnesses including eiating disorders, cachexia, obesity, diabetes, metabolic disorders, inflammation, pain, skin disorders; skin and hair coloration, male and female sexual dysfuntion, erectile dysfunction, dry eye acne and/or Cushing's disease. The compounds have the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein A, m, n R1, R2, R3a, R3b, R4, R5, R6, W1, W2, W3, W4, Y1, Y2, Y3 and Y4 area defined herin. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.