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    NOVEL QUINUCLIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE
    1.
    发明授权
    NOVEL QUINUCLIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE 有权
    新CHINUKLIDINDERIVATIVE和它们的药物用途

    公开(公告)号：EP1656375B1

    公开(公告)日：2011-01-19

    申请号：EP04741916.3

    申请日：2004-06-29

    申请人： NeuroSearch A/S ,  ABBOTT LABORATORIES

    发明人： PETERS, Dan ,  OLSEN, Gunnar M. ,  NIELSEN, Elsebet Ostergaard ,  AHRING, Philip K. ,  JORGENSEN, Tino Dyhring ,  SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B.

    IPC分类号： C07D453/02 ,  A61K31/439 ,  A61P25/00

    CPC分类号： C07D453/02

    摘要： This invention relates to novel quinuclidine derivatives represented by Formula (II) wherein represents an optional double bond; n is 1, 2 or 3; X represents a linker selected from -O-, -O-CH2-, -O-CH2-CH2-, -S-, -SO-, -SO2-, -CH2-, -S-CH2-CH2-,-CH2-, -C(=CH2)-, -NH-, -N(alkyl)-, -C(=O)-, -C(=S)-, oo, and ss; and Y represents O, S, SO2, or NR’ wherein R’ represents hydrogen or alkyl and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONANE DERIVATIVES AND THEIR MEDICAL USE
    8.
    发明授权
    NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONANE DERIVATIVES AND THEIR MEDICAL USE 有权
    新型1,4-DIAZA-BICYCLO [3.2.2]壬烷衍生物及其医疗用途

    公开(公告)号：EP2027122B1

    公开(公告)日：2010-03-10

    申请号：EP07729315.7

    申请日：2007-05-21

    申请人： NeuroSearch A/S

    发明人： PETERS, Dan ,  OLSEN, Gunnar M. ,  NIELSEN, Elsebet Østergaard ,  TIMMERMANN, Daniel, B. ,  LOECHEL, Steven, Charles ,  CHRISTENSEN, Jeppe, Kejser ,  DYHRING, Tino

    IPC分类号： C07D471/08 ,  A61K31/551 ,  A61P25/00 ,  A61P25/28

    CPC分类号： C07D471/08

    摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonane derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的1,4-二氮杂 - 双环[3.2.2]壬烷衍生物，其被发现是烟碱乙酰胆碱受体上的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于它们的药理学特征，本发明的化合物可用于疾病或病症等不同的那些涉及到中枢神经系统（CNS），外周神经系统（PNS）的疾病或相关病症的胆碱能系统的治疗有用 平滑肌收缩，内分泌疾病或病症，与神经变性有关的疾病或病症，与炎症相关的疾病或病症，由化学物质滥用终止引起的疼痛和戒断症状。