公开(公告)号：EP2949343A4

公开(公告)日：2016-08-31

申请号：EP14743793

申请日：2014-01-17

申请人： NEWBIO THERAPEUTICS INC

发明人： AN DEQIANG ,  HAN NIANHE ,  ZENG DI ,  YANG HANG ,  ZHU PENG ,  LI MINGZHEN ,  JIAN LI ,  YANG CHUN

IPC分类号： A61K47/48 ,  A61K39/395 ,  A61K45/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  C07D207/448 ,  C07D207/452

CPC分类号： A61K47/48715 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6889 ,  C07D207/452 ,  C07K16/32 ,  C07K2317/92

摘要： Disclosed are a type of tridentate linkers and use thereof. The tridentate linkers can be used to prepare an antibody drug conjugates as represented by formula I, wherein, L is an antibody, antibody fragment or protein; T is a tridentate linker part; A is a cleavable linker group or a noncleavable linker part; D is a drug part; n is an integer of 0-8. The structure of the tridentate linker part is as represented by formula II, wherein, W is substituted aryl, heteroaryl, linear alkyl, cycloalkyl, heterocycloalkyl, or any combination thereof. €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ L -(T-A-D) n €ƒ€ƒ€ƒ€ƒ€ƒ I