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1.发明公开
公开(公告)号：EP2925775A4
公开(公告)日：2016-07-13
申请号：EP13857983
申请日：2013-11-26
发明人： LING LEI , LINDHOUT DARRIN ANTHONY
IPC分类号： C07K14/50
CPC分类号： C07K14/50 , A61K38/1825 , A61K45/06 , C07K2319/00 , G01N33/66
摘要： The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of FGF19 and/or FGF21, and variants or fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
摘要翻译： 本发明涉及的变体和成纤维细胞生长因子19（FGF19）融合体，变异体和成纤维细胞生长因子21（FGF21），FGF19和/或FGF21的融合体，和变体或FGF19和/或FGF21蛋白和肽序列的融合物的融合体 （和肽模拟物），其具有一个或多个活动，：如葡萄糖降低活性，以及用于方法和治疗高血糖症和其它病症的用途。
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2.发明公开COMPOSITIONS, USES AND METHODS FOR TREATMENT OF METABOLIC DISORDERS AND DISEASES 审中-公开组合物中，体和方法使用代谢性疾病和病症的治疗
公开(公告)号：EP2726511A4
公开(公告)日：2015-12-02
申请号：EP12807786
申请日：2012-06-29
发明人： LING LEI , LINDHOUT DARRIN A
CPC分类号： C07K14/50 , A61K31/14 , A61K31/155 , A61K31/785 , A61K38/00 , A61K38/1825 , A61K45/06 , C07K2319/00 , C07K2319/30 , G01N33/5088 , G01N33/66
摘要： The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21), and variants or fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
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3.发明公开
公开(公告)号：EP3155005A4
公开(公告)日：2018-07-11
申请号：EP15810176
申请日：2015-06-15
CPC分类号： A61K38/28 , A61K31/155 , A61K31/165 , A61K31/519 , A61K31/52 , A61K31/573 , A61K31/575 , A61K31/64 , A61K38/13 , A61K38/1825 , A61K38/208 , A61K38/26 , A61K45/06 , C07K14/50 , C07K2319/00 , A61K2300/00
摘要： Provided herein are methods of modulating bile acid homeostasis or treating a bile-acid related or associated disorder, comprising using variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of FGF19 and/or FGF21, and variants or fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics), in combination with agents effective in modulating bile acid homeostasis or treating a bile-acid related or associated disorder.
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4.发明公开METHODS FOR MODULATING BILE ACID HOMEOSTASIS AND TREATMENT OF BILE ACID DISORDERS AND DISEASES 审中-公开方法的GALLENSÄUREHOMÖOSTASE的调节和治疗瘿酸病杂志
公开(公告)号：EP2938740A4
公开(公告)日：2016-11-30
申请号：EP13868063
申请日：2013-12-26
CPC分类号： A61K38/1825 , C07K14/50 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/92 , G01N2500/04 , G01N2800/04 , G01N2800/08
摘要： The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of FGF19 and/or FGF21, and variants or fusions of FGF19 and/or FG-F21 proteins and peptide sequences (and peptidomimetics), having one or more activities, such as bile acid homeostasis modulating activity, and methods for and uses in treatment of bile acid and other disorders.
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公开(公告)号：EP3062881A4
公开(公告)日：2017-03-29
申请号：EP14857066
申请日：2014-10-27
发明人： LING LEI
IPC分类号： A61P3/10
CPC分类号： G01N33/5088 , A01K67/0275 , A01K2227/105 , A01K2267/0331 , A61K38/1825 , G01N33/74 , G01N2800/04 , G01N2800/042 , G01N2800/7028 , G01N2800/7066
摘要： Provided are methods of antagonizing the oncogenic activity of FGF19 in a subject. Also provided are methods of treating a FGF19-dependent cancer or tumor, or a symptom thereof in a subject.
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