公开(公告)号：EP3786181A1

公开(公告)日：2021-03-03

申请号：EP20196341.0

申请日：2015-07-21

申请人： NIPPI, INCORPORATED

发明人： SAITO, Shinji ,  SUZUKI, Tadaki ,  HASEGAWA, Hideki ,  AINAI, Akira ,  GOTO, Kiyoko ,  UENO, Tomonori ,  TAGA, Yuki

IPC分类号： C07K16/18 ,  A61K39/395 ,  A61P31/00 ,  C12N15/09 ,  C12P21/08 ,  C07K16/10

摘要： Provided are: a polymeric IgA-type recombinant antibody; a medicine containing this polymeric IgA-type recombinant antibody as an active ingredient; a method for producing this polymeric IgA type antibody, the method including the step of coexpressing an IgA-type antibody heavy-chain protein, an antibody light-chain protein, an antibody J-chain protein, and a secretory component protein within a single cell; and a method for improving the antigen-binding activity or neutralizing activity of this antibody, the method including the step of making an antibody into a polymeric IgA-type.