公开(公告)号：EP1022276A4

公开(公告)日：2001-12-12

申请号：EP98941728

申请日：1998-09-04

申请人： NIPPON CHEMIPHAR CO

发明人： NOMURA YUTAKA ,  TAKAHASHI TOSHIHIRO ,  YOSHINO YASUSHI ,  NISHIOKA KOICHIRO

IPC分类号： A61P19/00 ,  C07D303/48 ,  C07D405/12 ,  A61K31/335 ,  A61K31/38 ,  A61K31/415 ,  A61K31/44 ,  A61K31/495 ,  C07D409/12

CPC分类号： C07D405/12 ,  C07D303/48

摘要： Novel epoxysuccinamide derivatives represented by general formula (1) or physiologically acceptable salts thereof, which are useful particularly as remedies for bone diseases and arthritis, wherein R?1 and R3¿ are each hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, a heterocyclic group, or alkyl substituted with a heterocyclic group; R2 is alkyl, alkenyl, alkynyl, aryl, aralkyl, a heterocyclic group, or alkyl substituted with a heterocyclic group; X is -O- or -NR4- (wherein R4 is hydrogen, alkyl, aryl, aralkyl, a heterocyclic group, or alkyl substituted with a heterocyclic group); Y?1 is OR5, SR6 or NR7R8¿ (wherein R?5, R6 and R7¿ are each hydrogen, alkyl, aryl, aralkyl, acyl, a heterocyclic group, or alkyl substituted with a heterocyclic group; and R8 is the same as defined as to R4); and Y2 is hydrogen or alkyl, or alternatively Y?1 and Y2¿ may be united to form =O, =S, =N-R9 or =N-OR10 (wherein R?9 and R10¿ are each the same as defined as to R4), with the proviso that the alkyl, aryl and heterocyclic groups defined as to R?5 to R10¿ may each have one or more specific substituents and that the groups defined as to R?1 to R10 and Y2¿ are each specified in the number of carbon atoms.