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13 条记录 (耗时 0.01 秒)

    EPOXYSUCCINAMIDE DERIVATIVES
    1.
    发明公开
    EPOXYSUCCINAMIDE DERIVATIVES 有权
    环氧琥珀衍生物

    公开(公告)号：EP1022276A4

    公开(公告)日：2001-12-12

    申请号：EP98941728

    申请日：1998-09-04

    申请人： NIPPON CHEMIPHAR CO

    发明人： NOMURA YUTAKA ,  TAKAHASHI TOSHIHIRO ,  YOSHINO YASUSHI ,  NISHIOKA KOICHIRO

    IPC分类号： A61P19/00 ,  C07D303/48 ,  C07D405/12 ,  A61K31/335 ,  A61K31/38 ,  A61K31/415 ,  A61K31/44 ,  A61K31/495 ,  C07D409/12

    CPC分类号： C07D405/12 ,  C07D303/48

    摘要： Novel epoxysuccinamide derivatives represented by general formula (1) or physiologically acceptable salts thereof, which are useful particularly as remedies for bone diseases and arthritis, wherein R?1 and R3¿ are each hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, a heterocyclic group, or alkyl substituted with a heterocyclic group; R2 is alkyl, alkenyl, alkynyl, aryl, aralkyl, a heterocyclic group, or alkyl substituted with a heterocyclic group; X is -O- or -NR4- (wherein R4 is hydrogen, alkyl, aryl, aralkyl, a heterocyclic group, or alkyl substituted with a heterocyclic group); Y?1 is OR5, SR6 or NR7R8¿ (wherein R?5, R6 and R7¿ are each hydrogen, alkyl, aryl, aralkyl, acyl, a heterocyclic group, or alkyl substituted with a heterocyclic group; and R8 is the same as defined as to R4); and Y2 is hydrogen or alkyl, or alternatively Y?1 and Y2¿ may be united to form =O, =S, =N-R9 or =N-OR10 (wherein R?9 and R10¿ are each the same as defined as to R4), with the proviso that the alkyl, aryl and heterocyclic groups defined as to R?5 to R10¿ may each have one or more specific substituents and that the groups defined as to R?1 to R10 and Y2¿ are each specified in the number of carbon atoms.

    AMINE DERIVATIVE
    3.
    发明公开
    AMINE DERIVATIVE 审中-公开
    AMINDERIVAT

    公开(公告)号：EP1538142A4

    公开(公告)日：2006-07-26

    申请号：EP03795320

    申请日：2003-09-09

    申请人： NIPPON CHEMIPHAR CO

    发明人： TENDO ATSUSHI ,  TAKAHASHI TOSHIHIRO ,  YAMAKAWA TOMIO

    IPC分类号： C07C217/08 ,  C07C29/06 ,  C07C211/02 ,  C07C213/08

    CPC分类号： C07C217/08

    摘要： The invention relates to (1S)-1-isobutoxymethyl-3- methylbutylamine useful as an intermediate in the synthesis of sodium (2S, 3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]- carbamoyl]oxirane-2-carboxylate and a process for production thereof. The process comprises reacting L-leucinol with a compound represented by the following general formula: [wherein X is a leaving group] in the presence of a base and reducing the obtained (1S)-1-(2-methyl-2-propenoxymethyl)-3-methylbutylamine.

    DIHYDROPHENAZINECARBOXYLIC ACID DERIVATIVES
    4.
    发明公开
    DIHYDROPHENAZINECARBOXYLIC ACID DERIVATIVES 失效
    DIHYDROPHENAZINCARBONSÄURE衍

    公开(公告)号：EP0945444A4

    公开(公告)日：2002-02-06

    申请号：EP97944108

    申请日：1997-10-14

    申请人： NIPPON CHEMIPHAR CO

    发明人： TAKAHASHI TOSHIHIRO ,  NOMURA YUTAKA ,  SETO HARUO ,  SHIN-YA KAZUO

    IPC分类号： C07D241/48 ,  C07D241/46 ,  A61K31/495

    CPC分类号： C07D241/48

    摘要： Dihydrophenazinecarboxylic acid derivatives represented by general formula (I) wherein R1 represents hydrogen, linear or branched alkyl, etc.; R?2 and R3¿ each represents hydrogen, 3-methyl-2-butenyl, etc.; and R?4 and R5¿ each represents hydrogen, alkyl, alkenyl, alkynyl, aralkyl, aryl, hydroxy, alkoxy, aryloxy, aralkyloxy, halogeno, nitro, cyano, alkylsulfonyl, arylsulfonyl, alkylcarbonyl, arylcarbonyl, etc., exclusive of the case where both of R?4 and R5¿ are hydrogen. The dihydrophenazinecarboxylic acid derivatives are excellent in the inhibition of glutamic acid toxicity.

    摘要翻译： 由通式（I）表示的二氢吩嗪羧酸衍生物，其中R1代表氢，直链或支链烷基等; R 2和R 3各自代表氢，3-​​甲基-2-丁烯基等; 烷基，烯基，炔基，芳烷基，芳基，羟基，烷氧基，芳氧基，芳烷氧基，卤素，硝基，氰基，烷基磺酰基，芳基磺酰基，烷基羰基，芳基羰基等， 其中R 4和R 5都是氢。 二氢吩嗪羧酸衍生物在抑制谷氨酸毒性方面极好。

    QUINAZOLINE DERIVATIVE
    8.
    发明公开
    QUINAZOLINE DERIVATIVE 失效
    CHINAZOLIN衍

    公开(公告)号：EP0794178A4

    公开(公告)日：1998-02-25

    申请号：EP95932948

    申请日：1995-09-29

    申请人： NIPPON CHEMIPHAR CO

    发明人： NISHIOKA KOICHIRO ,  TAKAHASHI TOSHIHIRO ,  NOMURA YUTAKA

    IPC分类号： C07D239/95 ,  A61K31/505

    CPC分类号： C07D239/95

    摘要： A quinazoline derivative represented by general formula (I), a pharmaceutically acceptable salt thereof, and a hypotensive containing the same and having a slow and persistant hypotensive effect, wherein R?1 and R2¿ represent each hydrogen or C¿1?-C6 alkyl, or R?1 and R2¿ are combined together to form an ethylene group; R?3 and R4¿ represent each C¿1?-C6 alkyl; R?5¿ represents hydrogen, hydroxy, C¿1?-C6 alkyl or C1-C6 alkoxy; R?6 and R7¿ represent each hydrogen or C¿1?-C6 alkyl; and n represents 2 or 3.

    摘要翻译： 由通式（I）表示的喹唑啉衍生物，其药学上可接受的盐和含有它们并具有缓慢且持久的降压作用的降压药，其中R 1和R 2代表氢或C 1 -C 6烷基 或R 1和R 2'结合在一起形成亚乙基; R 3和R 4代表各自的C 1 -C 6烷基; R 5表示氢，羟基，C 1 -C 6烷基或C 1 -C 6烷氧基; R 6和R 7代表氢或C 1 -C 6烷基; 并且n代表2或3。