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1.发明公开Antibiotic NK86-0279, process for production of the same and application of the same 失效抗生素NK 86-0279，其制备方法及其使用方法。
公开(公告)号：EP0322748A1
公开(公告)日：1989-07-05
申请号：EP88121449.8
申请日：1988-12-22
发明人： Yamashita, Takumi , Yamazaki, Masanori , Tsuchiya, Takako , Harada, Takashi , Saito, Seiichi , Shimada, Nobuyoshi , Kurokawa, Takashi , Hirose, Kiyonobu , Nishikiori, Takaaki
IPC分类号： C07D493/20 , C12P17/18 , A61K31/335
CPC分类号： C07D493/20 , C07H19/01 , C12P17/181 , C12R1/465
摘要： This invention relates to an antibiotic NK86-0279 of the formula:
which exhibits antifungal, antitumor, vascularizations-inhibitory and insecticidal activities, obtainable by culturing a microorganism of the genus Streptomyces, particularly Streptomyces bottropensis NK86-0279 (FERM BP-1787) and recovering the same from the culture medium. The invention also comprises a pure culture of this microorganism and mutants and variants thereof as well as pharmaceutical compositions comprising the new antibiotic.摘要翻译： 本发明涉及上式的抗生素NK86-0279：
哪些通过培养链霉菌属，特别是链霉菌bottropensis NK86-0279的微生物展品抗真菌，抗肿瘤，vascularizations抑制和杀虫活性，得到A（FERM BP-1787 ）并从该培养基中的相同。 因此本发明包括这种微生物和突变体的纯培养物和其变体以及药物组合物，包含新的抗生素。 -
2.发明授权Novel antibiotic NK130119, process for production of the same and application of the same 失效新型抗生素NK130119，其生产方法及其应用
公开(公告)号：EP0381124B1
公开(公告)日：1993-07-28
申请号：EP90101758.2
申请日：1990-01-30
发明人： Nishikiori, Takaaki , Yamazaki, Masanori , Saito, Seiichi , Shimada, Nobuyoshi , Kurokawa, Takashi , Hirose, Kiyonobu , Yamashita, Takumi , Harada, Takashi
IPC分类号： C07D498/20 , A61K31/365 , C12P17/08 , C12N1/20 , A01N43/90
CPC分类号： C07D493/20 , A01N43/90 , C12P17/181
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3.发明公开Novel antibiotic NK130119, process for production of the same and application of the same 失效Antibiotikum NK130119，Verfahren zu dessen Herstellung und Verwendung。
公开(公告)号：EP0381124A2
公开(公告)日：1990-08-08
申请号：EP90101758.2
申请日：1990-01-30
发明人： Nishikiori, Takaaki , Yamazaki, Masanori , Saito, Seiichi , Shimada, Nobuyoshi , Kurokawa, Takashi , Hirose, Kiyonobu , Yamashita, Takumi , Harada, Takashi
IPC分类号： C07D498/20 , A61K31/365 , C12P17/08 , C12N1/20 , A01N43/90
CPC分类号： C07D493/20 , A01N43/90 , C12P17/181
摘要： This invention relates to an antibiotic NK130119 of the formula:
which exhibits antifungal, antitumor, vascularizations-inhibitory and insecticidal activities.摘要翻译： 本发明涉及具有抗真菌，抗肿瘤，血管形成抑制和杀虫活性的下式的抗生素NK130119：
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4.发明授权Antibiotic NK86-0279, process for production of the same and application of the same 失效抗生素NK 86-0279，其制备方法及其使用方法。
公开(公告)号：EP0322748B1
公开(公告)日：1994-04-20
申请号：EP88121449.8
申请日：1988-12-22
发明人： Yamashita, Takumi , Yamazaki, Masanori , Tsuchiya, Takako , Harada, Takashi , Saito, Seiichi , Shimada, Nobuyoshi , Kurokawa, Takashi , Hirose, Kiyonobu , Nishikiori, Takaaki
IPC分类号： C07D493/20 , C12P17/18 , A61K31/335
CPC分类号： C07D493/20 , C07H19/01 , C12P17/181 , C12R1/465
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5.发明公开Novel antibiotic NK130119, process for production of the same and application of the same 失效新型抗生素NK130119，其生产方法及其应用
公开(公告)号：EP0381124A3
公开(公告)日：1991-03-27
申请号：EP90101758.2
申请日：1990-01-30
发明人： Nishikiori, Takaaki , Yamazaki, Masanori , Saito, Seiichi , Shimada, Nobuyoshi , Kurokawa, Takashi , Hirose, Kiyonobu , Yamashita, Takumi , Harada, Takashi
IPC分类号： C07D498/20 , A61K31/365 , C12P17/08 , C12N1/20 , A01N43/90
CPC分类号： C07D493/20 , A01N43/90 , C12P17/181
摘要： This invention relates to an antibiotic NK130119 of the formula:
which exhibits antifungal, antitumor, vascularizations-inhibitory and insecticidal activities.
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