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1.发明公开Antibiotic NK86-0279, process for production of the same and application of the same 失效抗生素NK 86-0279，其制备方法及其使用方法。
公开(公告)号：EP0322748A1
公开(公告)日：1989-07-05
申请号：EP88121449.8
申请日：1988-12-22
发明人： Yamashita, Takumi , Yamazaki, Masanori , Tsuchiya, Takako , Harada, Takashi , Saito, Seiichi , Shimada, Nobuyoshi , Kurokawa, Takashi , Hirose, Kiyonobu , Nishikiori, Takaaki
IPC分类号： C07D493/20 , C12P17/18 , A61K31/335
CPC分类号： C07D493/20 , C07H19/01 , C12P17/181 , C12R1/465
摘要： This invention relates to an antibiotic NK86-0279 of the formula:
which exhibits antifungal, antitumor, vascularizations-inhibitory and insecticidal activities, obtainable by culturing a microorganism of the genus Streptomyces, particularly Streptomyces bottropensis NK86-0279 (FERM BP-1787) and recovering the same from the culture medium. The invention also comprises a pure culture of this microorganism and mutants and variants thereof as well as pharmaceutical compositions comprising the new antibiotic.摘要翻译： 本发明涉及上式的抗生素NK86-0279：
哪些通过培养链霉菌属，特别是链霉菌bottropensis NK86-0279的微生物展品抗真菌，抗肿瘤，vascularizations抑制和杀虫活性，得到A（FERM BP-1787 ）并从该培养基中的相同。 因此本发明包括这种微生物和突变体的纯培养物和其变体以及药物组合物，包含新的抗生素。 -
2.发明授权Novel antibiotics NK374186A, NK374186B, NK374186B3 and NK374186C3, process for producing the same, and use of the same 失效抗生素NK374186A，NK374186B，NK374186B3和NK374186C3，其制备方法及其应用
公开(公告)号：EP0525361B1
公开(公告)日：1996-10-23
申请号：EP92110170.5
申请日：1992-06-16
发明人： Morino, Tomio , Nishimoto, Masakazu , Nishide, Mit uyuki , Masuda, Akira , Yamada, Masatoshi , Kawano, Eiji , Nishikiori, Takaaki , Saito, Seiichi
摘要： Novel antibiotics NK374186A, NK374186B, NK374186B3 and NK374186C3 having antibacterial, antineoplastic, immunomodulation, and liver regeneration promoting activities are provided. NK374186A, NK374186B, NK374186B3 and NK374186C3 are obtained by culturing NK374186 strain (FERM P-12285) (FERM-BP 3870) belonging to the genus Penicillium. NK374186A is a compound represented by a rational formula of C34H61N3O12S9 and having a molecular weight of M+ 735 (FD-MS m/z); NK374186B is a compound represented by a rational formula of C34H61N3O9 and having a molecular weight of M+ 655 (FD-MS m/z); NK374186B3 is a compound represented by a rational formula of C34H61N3O9 and having a molecular weight of M+ 655 (FD-MS m/z); and NK374186C3 is a compound represented by a rational formula of C32H59N3O7 and having a molecular weight of M+ 597 (FD-MS m/z).
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3.发明授权Novel antibiotic NK130119, process for production of the same and application of the same 失效新型抗生素NK130119，其生产方法及其应用
公开(公告)号：EP0381124B1
公开(公告)日：1993-07-28
申请号：EP90101758.2
申请日：1990-01-30
发明人： Nishikiori, Takaaki , Yamazaki, Masanori , Saito, Seiichi , Shimada, Nobuyoshi , Kurokawa, Takashi , Hirose, Kiyonobu , Yamashita, Takumi , Harada, Takashi
IPC分类号： C07D498/20 , A61K31/365 , C12P17/08 , C12N1/20 , A01N43/90
CPC分类号： C07D493/20 , A01N43/90 , C12P17/181
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4.发明授权Antibiotic NK86-0279, process for production of the same and application of the same 失效抗生素NK 86-0279，其制备方法及其使用方法。
公开(公告)号：EP0322748B1
公开(公告)日：1994-04-20
申请号：EP88121449.8
申请日：1988-12-22
发明人： Yamashita, Takumi , Yamazaki, Masanori , Tsuchiya, Takako , Harada, Takashi , Saito, Seiichi , Shimada, Nobuyoshi , Kurokawa, Takashi , Hirose, Kiyonobu , Nishikiori, Takaaki
IPC分类号： C07D493/20 , C12P17/18 , A61K31/335
CPC分类号： C07D493/20 , C07H19/01 , C12P17/181 , C12R1/465
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5.发明公开Novel antibiotic NK130119, process for production of the same and application of the same 失效新型抗生素NK130119，其生产方法及其应用
公开(公告)号：EP0381124A3
公开(公告)日：1991-03-27
申请号：EP90101758.2
申请日：1990-01-30
发明人： Nishikiori, Takaaki , Yamazaki, Masanori , Saito, Seiichi , Shimada, Nobuyoshi , Kurokawa, Takashi , Hirose, Kiyonobu , Yamashita, Takumi , Harada, Takashi
IPC分类号： C07D498/20 , A61K31/365 , C12P17/08 , C12N1/20 , A01N43/90
CPC分类号： C07D493/20 , A01N43/90 , C12P17/181
摘要： This invention relates to an antibiotic NK130119 of the formula:
which exhibits antifungal, antitumor, vascularizations-inhibitory and insecticidal activities.-
6.发明公开New antibiotics NK372135, process for the production thereof and use thereof 失效Antibiotika NK372135，Verfahren zu ihrer Herstellung und ihre Verwendung。
公开(公告)号：EP0394868A1
公开(公告)日：1990-10-31
申请号：EP90107530.9
申请日：1990-04-20
发明人： Nishimoto, Masakazu , Morino, Tomio , Takada, Kimihiko , Sato, Masaya , Takagi, Kenkichi , Seya, Kenji , Nishikiori, Takaaki
IPC分类号： C07C291/10 , A61K31/275 , A01N47/40 , C12P13/00
CPC分类号： C12P13/002 , A01N47/40 , C07C291/10 , C12R1/645
摘要： The present invention relates to antibiotics NK372135, which have antibacterial and antifungal actions and a 5-lipoxygenase inhibitory activity, represented by the following formula:
or salts thereof and a process for the production of the same by fermentation.摘要翻译： 本发明涉及具有抗细菌和抗真菌作用的抗生素NK372135和由下式表示的5-脂氧合酶抑制活性：
或其盐，以及通过发酵生产其的方法。 -
7.发明公开Novel antibiotics NK374186A, NK374186B, NK374186B3 and NK374186C3, process for producing the same, and use of the same 失效抗生素NK374186A，NK374186B，NK374186B3和NK374186C3，其制备方法及其用途。
公开(公告)号：EP0525361A1
公开(公告)日：1993-02-03
申请号：EP92110170.5
申请日：1992-06-16
发明人： Morino, Tomio , Nishimoto, Masakazu , Nishide, Mit uyuki , Masuda, Akira , Yamada, Masatoshi , Kawano, Eiji , Nishikiori, Takaaki , Saito, Seiichi
摘要： Novel antibiotics NK374186A, NK374186B, NK374186B3 and NK374186C3 having antibacterial, antineoplastic, immunomodulation, and liver regeneration promoting activities are provided.
NK374186A, NK374186B, NK374186B3 and NK374186C3 are obtained by culturing NK374186 strain (FERM P-12285) (FERM-BP 3870) belonging to the genus Penicillium. NK374186A is a compound represented by a rational formula of C 34 H 61 N 12 S 9 and having a molecular weight of M+ 735 (FD-MS m/z); NK374186B is a compound represented by a rational formula of C 34 H 61 N 3 O 9 and having a molecular weight of M + 655 (FD-MS m/z); NK374186B3 is a compound represented by a rational formula of C 34 H 61 N 3 O 9 and having a molecular weight of M + 655 (FD-MS m/z); and NK374186C3 is a compound represented by a rational formula of C 32 H 59 N 3 O 7 and having a molecular weight of M+ 597 (FD-MS m/z).摘要翻译： 提供了新的抗生素NK374186A NK374186B NK374186B3和NK374186C3具有抗菌，抗肿瘤，免疫调节，以及肝脏的再生促销廷活动。 NK374186A NK374186B NK374186B3和NK374186C3通过培养属于青霉属菌株NK374186（FERM P-12285）（FERM BP-3870）中获得。 NK374186A是通过C34H61N3O12S9的合理配方和具有M + 735（FD-MS M / Z）的分子量表示的化合物; NK374186B是通过C34H61N3O9的合理配方和具有M + 655（FD-MS M / Z）的分子量表示的化合物; NK374186B3是通过C34H61N3O9的合理配方和具有M + 655（FD-MS M / Z）的分子量表示的化合物; 和NK374186C3是具有M + 597（FD-MS M / Z）的分子量通过C32H59N3O7的理性式表示的化合物和。
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8.发明公开Novel antibiotic NK130119, process for production of the same and application of the same 失效Antibiotikum NK130119，Verfahren zu dessen Herstellung und Verwendung。
公开(公告)号：EP0381124A2
公开(公告)日：1990-08-08
申请号：EP90101758.2
申请日：1990-01-30
发明人： Nishikiori, Takaaki , Yamazaki, Masanori , Saito, Seiichi , Shimada, Nobuyoshi , Kurokawa, Takashi , Hirose, Kiyonobu , Yamashita, Takumi , Harada, Takashi
IPC分类号： C07D498/20 , A61K31/365 , C12P17/08 , C12N1/20 , A01N43/90
CPC分类号： C07D493/20 , A01N43/90 , C12P17/181
摘要： This invention relates to an antibiotic NK130119 of the formula:
which exhibits antifungal, antitumor, vascularizations-inhibitory and insecticidal activities.摘要翻译： 本发明涉及具有抗真菌，抗肿瘤，血管形成抑制和杀虫活性的下式的抗生素NK130119：
。
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