公开(公告)号：EP0454863B1

公开(公告)日：1993-11-03

申请号：EP90916804.9

申请日：1990-11-15

申请人： NIPPON SODA CO., LTD.

发明人： TSUKASHIMA, K. Takaoka Plant, Nippon Soda Co., Ltd ,  KANEKO, Akira Takaoka Plant, Nippon Soda Co., Ltd.

IPC分类号： C07C45/72 ,  C07C49/17 ,  C07C49/172 ,  C07C49/245 ,  C07C323/22 ,  C07D335/02 ,  C07D309/06 ,  C07D307/46

CPC分类号： C07D335/02 ,  C07C45/72 ,  C07C201/12 ,  C07C319/20 ,  C07C2601/14 ,  C07D309/06 ,  C07C49/17 ,  C07C49/245 ,  C07C49/172 ,  C07C323/22 ,  C07C205/45

摘要： The present invention relates to a method for the preparation of β-hydroxyketones represented by general formula (I), (where R is an alkyl group which may have a methyl group at the α position, an alkyl group substituted by alkylthio group which may have a methyl group at the α position, an alicyclic group which may have substituents at positions other than the α, β and β' positions, a heterocyclic group which may have substituents at positions other than the α, β and β' positions, and phenyl group which may have an electron withdrawing group at the para position), by reacting aldehydes represented by formula (A): RCHO (where R is as defined above) with aqueous solution of alkali metal salt of acetoacetic acid represented by formula (B) (where M+ is an alkali metal ion), a method for the preparation of the said β-hydroxyketones which comprises reacting (A) and (B) when a mole ratio of (A) to (B) is 1.0 to 1.5 if (A) has two hydrogen atoms, 1.5 to 2.0 if one hydrogen atom, 2.0 to 2.5 if no hydrogen atoms and 1.1 to 1.5 if R is a phenyl group with electron withdrawing group at the para position even if no hydrogen atoms, at a pH of 9 to 10.