公开(公告)号：EP2747886B1

公开(公告)日：2018-11-14

申请号：EP12766450.6

申请日：2012-09-27

Applicant: Firmenich SA

Inventor： DUPAU, Philippe ,  BONOMO, Lucia ,  KERMORVAN, Laurent

IPC: B01J31/18 ,  B01J31/24 ,  B01J31/22 ,  C07B41/02 ,  C07C29/141 ,  C07C67/00 ,  C07C29/145

CPC classification number: C07C29/141 ,  B01J31/1805 ,  B01J31/181 ,  B01J31/2226 ,  B01J31/24 ,  B01J31/2409 ,  B01J2231/643 ,  B01J2531/0238 ,  B01J2531/821 ,  C07B41/02 ,  C07B2200/07 ,  C07C29/145 ,  C07C45/64 ,  C07C67/00 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/10 ,  C07C2601/16 ,  C07C2601/18 ,  C07C2602/42 ,  C07C33/12 ,  C07C49/17 ,  C07C49/172 ,  C07C49/573 ,  C07C33/025 ,  C07C69/145 ,  C07C33/30 ,  C07C33/03 ,  C07C69/24 ,  C07C69/78 ,  C07C49/337 ,  C07C49/242

Abstract: The present invention relates to processes for the reduction by hydrogenation, using molecular H2, of a C5-C20 substrate containing one or two aldehydes functional groups into the corresponding alcohol or diol, characterized in that said process is carried out in the presence of —at least one catalyst or pre-catalyst in the form of a ruthenium complex having a coordination sphere of the N2P2O2, wherein the coordinating atoms N2 are provided by a first bidentate ligand, the coordinating atoms P2 are provided by a second bidentate ligand and the coordinating atoms O2 are provided by two non-linear carboxylate ligands; and—optionally of an acidic additive.

公开(公告)号：EP3110784A1

公开(公告)日：2017-01-04

申请号：EP14884140.6

申请日：2014-02-28

Applicant: Rhodia Operations ,  Centre National de la Recherche Scientifique ,  Université de Poitiers

Inventor： DE CAMPO, Floryan ,  CLACENS, Jean-Marc ,  JEROME, Francois ,  DE OLIVEIRA VIGIER, Karine ,  LIU, Fei

IPC: C07C49/12 ,  C07C45/37 ,  C07C45/62 ,  C07C51/12

CPC classification number: C07C45/59 ,  B01J21/18 ,  B01J23/44 ,  B01J31/10 ,  B01J35/0006 ,  B01J35/02 ,  B01J2231/48 ,  B01J2531/002 ,  B01J2531/005 ,  C07C51/00 ,  C07C51/31 ,  Y02P20/582 ,  C07C49/17 ,  C07C59/185

Abstract: Providing a catalytic process for preparing 1,4-diketone compounds from furanic compounds and their precursors in a liquid medium, using an acid catalytic system and optionally in the presence of hydrogen and a hydrogenation catalyst, wherein the acidic catalytic system comprises a solid acid catalyst or a mixture of water and CO2.

Abstract translation: 提供催化方法，使用酸催化体系和任选在氢气和氢化催化剂的存在下，由呋喃化合物及其前体在液体介质中制备1,4-二酮化合物，其中酸性催化体系包含固体酸催化剂 或水和二氧化碳的混合物。

公开(公告)号：EP2298721A2

公开(公告)日：2011-03-23

申请号：EP10184192.2

申请日：2005-03-24

Applicant: Suppes, Galen J. ,  Sutterlin, William Rusty ,  Dasari, Mohanprasad A.

Inventor： Suppes, Galen J. ,  Sutterlin, William Rusty ,  Dasari, Mohanprasad A.

IPC: C07C29/145 ,  C07C29/60 ,  C07C45/52 ,  C07C49/17 ,  C09K3/18 ,  C09K5/20

CPC classification number: C09K3/18 ,  C07C29/145 ,  C07C29/60 ,  C07C45/52 ,  C09K3/185 ,  C09K5/20 ,  C12C11/02 ,  Y02P20/52 ,  C07C31/04 ,  C07C31/205 ,  C07C49/17

Abstract: A composition for use as an antifreeze, deicing agent, or anti-icing agent produced from the crude glycerol byproduct of the C 1 to C 4 alkyl alcohol alcoholysis of a glyceride comprised of:
on a water-free basis, from about 0.5% to about 60% glycerol, and from about 20% to about 85% propylene glycol.

Abstract translation: 作为防冻剂，除冰剂或抗冻剂使用的组合物从C1到由甘油酯的C 4烷基醇醇解的粗丙三醇副产物制备：不含水的基础上，从约0.5％至 约60％的甘油，以及约20％至约85％的丙二醇。

公开(公告)号：EP2286915A2

公开(公告)日：2011-02-23

申请号：EP10185093.1

申请日：2006-01-04

Applicant: The Queen's University of Belfast

Inventor： Earle, Martyn John ,  Seddon, Kenneth Richard ,  Forsyth, Stewart ,  Frohlich, Ute ,  Gunaratne, Nimal ,  Katdare, Suhas

IPC: B01J31/02 ,  C07D301/12 ,  C07C209/60 ,  C07C45/72 ,  C07C45/69 ,  C07C45/62 ,  C07B37/04

CPC classification number: C07C217/08 ,  B01J31/0201 ,  B01J31/0204 ,  B01J31/0225 ,  B01J31/0234 ,  B01J31/0237 ,  B01J31/0277 ,  B01J31/0278 ,  B01J31/0282 ,  B01J31/0284 ,  B01J31/0287 ,  B01J31/0288 ,  B01J31/0289 ,  B01J31/0291 ,  B01J31/2208 ,  B01J2231/341 ,  B01J2231/342 ,  B01J2231/346 ,  B01J2231/348 ,  B01J2231/349 ,  B01J2231/4261 ,  B01J2231/645 ,  B01J2231/72 ,  B01J2531/824 ,  B01J2531/90 ,  C07B61/00 ,  C07C45/512 ,  C07C45/62 ,  C07C45/66 ,  C07C45/67 ,  C07C45/72 ,  C07C45/73 ,  C07C45/74 ,  C07C211/63 ,  C07D213/73 ,  C07D233/54 ,  C07D303/32 ,  Y02P20/542 ,  C07C47/228 ,  C07C49/603 ,  C07C49/647 ,  C07C49/637 ,  C07C49/203 ,  C07C49/597 ,  C07C49/497 ,  C07C49/707 ,  C07C49/17 ,  C07C49/403

Abstract: Use of ionic liquids as solvents in base-catalysed chemical reactions wherein the ionic liquid is composed of at least one species of cation and at least one species of anion, characterised in that a cation of the ionic liquid comprises a positively charge moiety and a basic moiety, and further wherein such ionic liquids may be used as promoters or catalysts for the chemical reactions.

Abstract translation: 在碱催化的化学反应中使用离子液体作为溶剂，其中离子液体由至少一种阳离子和至少一种阴离子组成，其特征在于离子液体的阳离子包含正电荷部分和碱性 部分，其中这种离子液体可以用作化学反应的促进剂或催化剂。

公开(公告)号：EP2150516A1

公开(公告)日：2010-02-10

申请号：EP08758814.1

申请日：2008-05-28

Applicant: DSM IP Assets B.V.

Inventor： BONRATH, Werner ,  FLEISCHHAUER, Henning ,  HÖLDERICH, Wolfgang, F. ,  SCHÜTZ, Jan

IPC: C07C45/72

CPC classification number: C07C45/75 ,  C07C45/74 ,  Y02P20/584 ,  C07C49/203 ,  C07C49/17

Abstract: The invention relates to a novel processes for cross aldol reactions using strongly basic, anionic, macroreticular polymeric resin with quaternary ammonium groups of the type -CH2N+(CH3)3 as heterogeneous catalysts. This catalyst is recyclable and the process can be repeated several times.

公开(公告)号：EP1948582A2

公开(公告)日：2008-07-30

申请号：EP06836781.2

申请日：2006-10-31

Applicant: University of Missouri Board of Curators

Inventor： SUPPES, Galen, J. ,  SUTTERLIN, William, Rusty

IPC: C07C29/132 ,  C07C29/145 ,  C07C45/52 ,  C07C49/17 ,  C09K5/20

CPC classification number: C07C29/145 ,  C07C29/60 ,  C07C45/52 ,  C09K5/20 ,  C12C11/02 ,  C07C31/205 ,  C07C49/17

Abstract: A reactive-separation process converts glycerin into lower alcohols, having boiling points less than 2000C, at high yields. Conversion of natural glycerin to propylene glycol through an acetol intermediate is achieved at temperatures from 150° to 2500C at pressures from 1 and 25 bar. The preferred applications of the propylene glycol are as an antifreeze, deicing compound, or anti-icing compound. The preferred catalyst for this process in a copper-chromium.

公开(公告)号：EP1809592B1

公开(公告)日：2008-03-12

申请号：EP05800293.2

申请日：2005-10-27

Applicant: FIRMENICH SA

Inventor： NAEF, Ferdinand ,  DECORZANT, René

IPC: C07C45/72 ,  C07C49/17

CPC classification number: C07C49/17 ,  C07C45/72

Abstract: The present invention relates to a process for the preparation of compounds of a 1,4-dialkyl-2,3-diol-1,4-butanedione by a catalytic aldol condensation between an alkyl glyoxal and an a-hydroxy ketone.

公开(公告)号：EP1853385A2

公开(公告)日：2007-11-14

申请号：EP06700155.2

申请日：2006-01-04

Applicant: The Queens University of Belfast

Inventor： EARLE, Martyn, John The Queen's University ,  SEDDON, Kenneth, Richard The Queen's University ,  FORSYTH, Stewart The Queen's University ,  FROHLICH, Ute The Queen's University ,  GUNARATNE, Nimal The Queen's University ,  KATDARE, Suhas The Queen's University

IPC: B01J31/02 ,  C07D301/12 ,  C07C209/60 ,  C07C45/72 ,  C07C45/69 ,  C07C45/62 ,  C07B37/04

CPC classification number: C07C217/08 ,  B01J31/0201 ,  B01J31/0204 ,  B01J31/0225 ,  B01J31/0234 ,  B01J31/0237 ,  B01J31/0277 ,  B01J31/0278 ,  B01J31/0282 ,  B01J31/0284 ,  B01J31/0287 ,  B01J31/0288 ,  B01J31/0289 ,  B01J31/0291 ,  B01J31/2208 ,  B01J2231/341 ,  B01J2231/342 ,  B01J2231/346 ,  B01J2231/348 ,  B01J2231/349 ,  B01J2231/4261 ,  B01J2231/645 ,  B01J2231/72 ,  B01J2531/824 ,  B01J2531/90 ,  C07B61/00 ,  C07C45/512 ,  C07C45/62 ,  C07C45/66 ,  C07C45/67 ,  C07C45/72 ,  C07C45/73 ,  C07C45/74 ,  C07C211/63 ,  C07D213/73 ,  C07D233/54 ,  C07D303/32 ,  Y02P20/542 ,  C07C47/228 ,  C07C49/603 ,  C07C49/647 ,  C07C49/637 ,  C07C49/203 ,  C07C49/597 ,  C07C49/497 ,  C07C49/707 ,  C07C49/17 ,  C07C49/403

Abstract: Use of ionic liquids as solvents in base-catalysed chemical reactions wherein the ionic liquid is composed of at least one species of cation and at least one species of anion, characterised in that a cation of the ionic liquid comprises a positively charge moiety and a basic moiety, and further wherein such ionic liquids may be used as promoters or catalysts for the chemical reactions.

公开(公告)号：EP1358144B1

公开(公告)日：2006-12-27

申请号：EP01987736.4

申请日：2001-10-16

Applicant: R&D-Biopharmaceuticals

Inventor： WESSJOHANN, Ludger, A. ,  SCHEID, Günther ,  BORNSCHEUER, Uwe ,  HENKE, Erik ,  KUIT, Wouter ,  ORRU, Romano

IPC: C07C49/00

CPC classification number: C07D417/06 ,  C07B2200/07 ,  C07C45/673 ,  C07C45/72 ,  C07C49/17 ,  C07C49/175 ,  C07C49/24 ,  C07C49/245 ,  C07C49/255 ,  C07C69/007 ,  C07C69/738 ,  C07D233/38 ,  C07D263/12 ,  C07D263/22 ,  C07D263/26 ,  C07D277/24 ,  C07D309/12 ,  C07D317/24 ,  C07D417/12 ,  C07D493/04 ,  C07F7/1852 ,  C07F7/1856

Abstract: The invention relates to racemic and especially non-racemic acyloins, the derivatives thereof, a method for the production thereof and the use of the same for producing epothilones and their derivatives. The invention especially relates to the production of acyloins in a non-racemic form by means of diastereomer separation or synthesis using auxiliary agents and by means of enzymatic resolution of racemates. The invention also relates to epothilone synthesis components, a method for the production thereof and the use of synthesis components for producing epothilones and their derivatives. An especially preferred compound comprises the following general formula.

公开(公告)号：EP1326822A2

公开(公告)日：2003-07-16

申请号：EP01981499.5

申请日：2001-10-11

Applicant: Esperion Therapeutics Inc.

Inventor： DASSEUX, Jean-Louis, H. ,  ONICIU, Carmen, Daniela

IPC: C07C49/17 ,  C07C49/245 ,  C07C49/258 ,  C07C49/185 ,  A61K31/12 ,  A61K31/185 ,  A61K31/21 ,  A61K31/275 ,  A61K31/095 ,  A61K31/33 ,  A61K31/66 ,  C07C49/782 ,  C07C49/215 ,  C07C49/723 ,  C07C49/743 ,  C07C49/747 ,  C07C49/507 ,  C07C50/30 ,  C07C261/04 ,  C07F9/09 ,  C07F9/24

CPC classification number: C07D257/04 ,  C07C49/17 ,  C07C49/185 ,  C07C49/215 ,  C07C49/245 ,  C07C49/258 ,  C07C49/507 ,  C07C49/723 ,  C07C49/743 ,  C07C49/747 ,  C07C49/782 ,  C07C49/82 ,  C07C49/86 ,  C07C50/30 ,  C07C59/347 ,  C07C59/353 ,  C07C59/84 ,  C07C69/716 ,  C07C69/738 ,  C07C261/04 ,  C07C309/07 ,  C07C309/24 ,  C07D233/72 ,  C07D233/84 ,  C07D233/86 ,  C07D261/12 ,  C07D305/12 ,  C07D307/33 ,  C07D309/12 ,  C07D309/30 ,  C07D309/40 ,  C07D495/04 ,  C07F9/093 ,  C07F9/2425 ,  C07F9/4423

Abstract: The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.