公开(公告)号：EP1537866A4

公开(公告)日：2009-03-11

申请号：EP03795352

申请日：2003-09-10

申请人： NIPPON ZOKI PHARMACEUTICAL CO

发明人： NAIKI MITSURU ,  NUMAZAWA TAKUMI

IPC分类号： A61K31/22 ,  A61P13/12

CPC分类号： A61K31/22

摘要： A drug for kidney failure containing, as the active ingredient, an oxaluric acid derivative which has an excellent effect of inhibiting the progress of kidney failure. The above-described compound, i.e., the oxaluric acid derivative has an excellent effect of inhibiting the progress of kidney failure by significantly inhibiting an increase in blood creatinine accompanying the progress of kidney failure while showing a high safety with little side effects. Thus, it is highly useful as a drug for kidney failure which is required to be administered over a long time.

公开(公告)号：EP3120848A4

公开(公告)日：2017-03-08

申请号：EP15764236

申请日：2015-03-19

申请人： NIPPON ZOKI PHARMACEUTICAL CO LTD

发明人： NAIKI MITSURU ,  NUMAZAWA TAKUMI ,  FUJISAWA HIROKI

IPC分类号： A61K31/37 ,  A61P11/00 ,  A61P19/02 ,  A61P29/00 ,  C07D311/18 ,  C07D405/12 ,  C07D409/12

CPC分类号： A61K31/37 ,  A61K9/007 ,  A61K31/381 ,  A61K31/4433 ,  A61K31/635 ,  C07D311/12 ,  C07D311/18 ,  C07D405/12 ,  C07D409/12

摘要： An object of the present invention is to provide a preventive or therapeutic agent for inflammatory diseases or degenerative intervertebral disk diseases. A coumarin derivative or a pharmaceutically acceptable salt or hydrate thereof which is an active ingredient of the preventive or therapeutic agent of the present invention exhibits an excellent suppressive action in a pharmacological test where production of inflammation-related factor such as inflammatory cytokine or fibrosis-related factor as an index. Moreover, said compound also exhibits an excellent suppressive action to pulmonary fibrosis model animals and degenerative intervertebral disk disease model animals. Accordingly, the present invention is very useful as a preventive or therapeutic agent for inflammatory diseases and degenerative intervertebral disk diseases.