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1.发明公开
公开(公告)号：EP4144835A1
公开(公告)日：2023-03-08
申请号：EP21797636.4
申请日：2021-04-26
IPC分类号： C12N5/077 , A61K35/32 , A61L27/36 , A61L27/38 , A61L27/40 , A61L27/58 , A61P19/08 , A61P43/00
摘要： The present invention provides a means for efficiently preparing a cell population rich in functional chondrocytes that produce an extracellular matrix such as type II collagen. This culture method according to the present invention involves a method of culturing a cell population containing cartilage-derived cells positive for expression of Tie2 (cartilage-derived Tie2-positive cells), the method comprising culturing a cell population containing cartilage-derived Tie2-positive cells in a culture medium containing at least one kind of Tie2 expression enhancer other than growth factors (e.g., an extract derived from a plant of the genus Cinnamomum). This culturing method is preferably performed in cultureware having a culture surface coated with a coating agent (e.g., a polylysine-containing agent).
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公开(公告)号：EP3730144A1
公开(公告)日：2020-10-28
申请号：EP18892293.4
申请日：2018-12-20
发明人： TANAKA, Hiroyuki , YOSHIKAWA, Hideki , MOCHIZUKI, Hideki , MURASE, Tsuyoshi , SASAKI, Tsutomu , BABA, Kousuke , IWAHASHI, Toru , NAIKI, Mitsuru
IPC分类号： A61K31/714 , A61K9/08 , A61P7/02 , A61P9/00 , A61P9/10 , A61P25/00 , A61P25/28 , C07D487/22
摘要： An object is to provide a drug which is useful in treating a nervous system disease. A drug containing vitamin B 12 as an active ingredient according to the present invention has an M2 macrophage/microglia induction promoting effect, an M1 macrophage/microglia induction inhibiting effect, a nerve regeneration promoting effect, and the like and is very useful as a therapeutic agent for a nervous system disease, and particularly useful as a therapeutic agent for a central nervous system disease such as cerebral infarction, dementia, or spinal cord injury.
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公开(公告)号：EP3527215A1
公开(公告)日：2019-08-21
申请号：EP19158239.4
申请日：2019-02-20
发明人： Sakai, Daisuke , Nakai, Tomoko , Naiki, Mitsuru , Shibayama, Yoji
摘要： An object of the present invention is to provide an agent for promoting expression of N-acetylgalactosaminyltransferase that contains an extract from inflamed tissues inoculated with vaccinia virus. The present invention demonstrated that the extract from inflamed tissues inoculated with vaccinia virus promotes the expression of N-acetylgalactosaminyltransferase in intervertebral disc cells. Thus, the extract from inflamed tissues inoculated with vaccinia virus or a preparation containing the extract is useful as an agent for promoting the expression of N-acetylgalactosaminyltransferase in intervertebral disc cells.
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公开(公告)号：EP2992889B1
公开(公告)日：2019-06-19
申请号：EP14791811.4
申请日：2014-04-30
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公开(公告)号：EP3456710A1
公开(公告)日：2019-03-20
申请号：EP17796123.2
申请日：2017-05-09
IPC分类号： C07C405/00 , A61K31/5575 , A61K47/40 , A61P7/02 , A61P9/08 , A61P9/10 , A61P43/00
摘要： The present invention relates to a novel prostaglandin derivative having an alkynyl group on ω-chain, particularly, a novel prostaglandin derivative having a double bond at the 2-position and an alkynyl group on the ω-chain and a medicament containing the compound as an active ingredient.
According to the present invention, a compound represented by the formula (1) or a pharmaceutically acceptable salt thereof;
wherein each symbol is as defined in the present specification, or a cyclodextrin clathrate compound thereof, and a medicament containing the compound as an active ingredient, particularly, a medicament for the prophylaxis or treatment of a blood flow disorder associated with spinal canal stenosis or chronic arterial occlusion, can be provided.-
公开(公告)号：EP2835424B1
公开(公告)日：2019-02-20
申请号：EP13772453.0
申请日：2013-04-02
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公开(公告)号：EP3351534A1
公开(公告)日：2018-07-25
申请号：EP16841688.1
申请日：2016-08-26
发明人： ITO, Taizo , LIAO, Xiaoming , LI, Zihua
IPC分类号： C07D223/04 , C07D223/14 , A61K31/55 , A61P25/04 , C07B51/00
CPC分类号： C07D223/04 , A61K31/55 , C07B51/00 , C07D223/14
摘要： An object of the present invention is to provide a novel tetrahydroazepine compound and a process for producing the same.
The present invention relates to a tetrahydroazepine compound represented by the formula (10) or a salt thereof, and a process for producing the said compound or a salt thereof.
(In the formula,
R 1 is an optionally substituted alkyl group,
R 2 is an optionally substituted alkyl group and
one of the X-Y bond and the Y-Z bond is a carbon-carbon double bond and the other is a carbon-carbon single bond.)-
8.发明授权AGENTS FOR USE FOR PROMOTING THE SYNTHESIS OF COLLAGEN AND PROTEOGLYCAN IN INTERVERTEBRAL DISC CELLS 有权用于促进椎间盘细胞中胶原蛋白和蛋白多糖合成的药物
公开(公告)号：EP2627343B1
公开(公告)日：2018-01-10
申请号：EP11833245.1
申请日：2011-10-11
发明人： MASUDA, Koichi , NAIKI, Mitsuru
CPC分类号： C12Q1/025 , A61K35/32 , A61K35/36 , A61K35/76 , G01N33/5082 , G01N2333/07
摘要： The synthesis of collagen and proteoglycan in chondrocytes, such as intervertebral disc cells, articular chondrocytes and meniscal cells is promoted by administration of an extract from inflamed tissue inoculated with vaccinia virus.
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公开(公告)号：EP2940003A4
公开(公告)日：2017-03-08
申请号：EP13868904
申请日：2013-12-27
IPC分类号： C07C233/22 , A61K31/165 , A61K31/40 , A61K31/4045 , A61K31/415 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/4402 , A61K31/495 , A61P25/04 , C07D207/335 , C07D209/14 , C07D213/40 , C07D231/12 , C07D231/56 , C07D233/64 , C07D235/06 , C07D249/04 , C07D261/08
CPC分类号： C07D295/13 , C07C233/40 , C07C233/51 , C07C279/12 , C07C2601/14 , C07D207/335 , C07D209/14 , C07D209/16 , C07D213/40 , C07D231/12 , C07D231/56 , C07D233/64 , C07D235/06 , C07D249/04 , C07D249/08 , C07D261/08 , C07D295/12
摘要： The present invention provides a cinnamic acid amide derivative having an excellent analgesic action. The cinnamic acid amide derivative of the present invention is a compound showing excellent analgesic actions to not only a nociceptive pain model animal but also a neuropathic pain model animal, which is very useful as an agent for treating various pain diseases showing acute or chronic pains or neuropathic pains.
摘要翻译： 本发明提供具有优异镇痛作用的肉桂酸酰胺衍生物。 本发明的肉桂酸酰胺衍生物是对不仅伤害性疼痛模型动物而言还具有极好的镇痛作用的化合物，而且也是神经性疼痛模型动物，其作为用于治疗各种疼痛疾病的药剂非常有用，所述疼痛疾病显示急性或慢性疼痛或 神经性疼痛
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公开(公告)号：EP2269558B1
公开(公告)日：2015-03-04
申请号：EP09735213.2
申请日：2009-04-23
发明人： NAKANO, Hideshi , NISHIMURA, Hideo
CPC分类号： B65D1/0238 , A61J1/067 , B65D1/095
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