公开(公告)号：EP0742211A4

公开(公告)日：1997-03-26

申请号：EP95906505

申请日：1995-01-24

申请人： NISSAN CHEMICAL IND LTD

发明人： TANIKAWA KEIZO ,  MATSUMOTO TAKASHI ,  MATSUMOTO HIROO ,  TSURUZOE NOBUTOMO ,  NAKABEPPU HITOSHI

IPC分类号： C07D237/22 ,  C07D401/12 ,  A61K31/50

CPC分类号： C07D401/12 ,  C07D237/22

摘要： A pyridazinone derivative represented by general formula (I) and an antithrombocytic agent containing the same, wherein R represents hydrogen or C1-C4 alkyl; X represents hydrogen, chlorine or bromine; An represents pyridyl or phenyl substituted by OR1 (R1 representing hydrogen or C¿1?-C4 alkyl) and A (representing hydrogen, halogen, C1-C4 alkyl or OR?2 (R2¿ representing hydrogen or C¿1?-C4 alkyl)); Y represents C1-C8 alkylene wherein one carbon atom on the straight chain is substituted by one OR?1¿ group (R1 being as defined as above); and Z?1 and Z2¿ represent each independently hydrogen, halogen, C¿1?-C4 alkyl or OR?1 (R1¿ being as defined above). This compound has a potent antithrombocytic activity and an excellent safety and is used as the active ingredient of a preventive or remedy for various thrombotic diseases.