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公开(公告)号:EP0693480A4
公开(公告)日:1996-09-25
申请号:EP94912072
申请日:1994-04-07
发明人: TANIKAWA KEIZO , KAMIKAWAJI YOSHIMASA , ODOI KEISUKE , HIGASHIYAMA TSUTOMU , SATO MASAYUKI , MASUDA YUKINORI
IPC分类号: C07D231/38 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07F9/6558 , A61K31/415 , A61K31/675 , C07D231/40 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D413/00 , C07F9/6503 , C07H19/02
CPC分类号: C07D231/38 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07F9/65583
摘要: A pyrazole compound represented by general formula (1), tautomers thereof, and salts of both; (wherein R1 represents alkyl, etc.; R2 represents carboxyl, etc.; R3 represents halogen, alkyl, phenyl, etc.; R?4, R5 and R6¿ represent each hydrogen, halogen, etc.; R7 represents carboxyl, 5-tetrazolyl, etc.; X represents nitrogen, etc.; Y and Z represent each CH, nitrogen, etc.; A and E represent each methylene, etc.; D represents phenyl, etc.; and G represents a covalent bond, etc.), having angiotensin II antagonism and being useful for preventing or treating hypertension, congestive heart failure, chronic renal failure, aldosteronism, increased intraocular pressure, and so forth.
摘要翻译: 通式(1)表示的吡唑化合物,其互变异构体和两者的盐; (其中R1代表烷基等; R2代表羧基等; R3代表卤素,烷基,苯基等; R14,R5和R6代表氢,卤素等; R7代表羧基, 四唑基等; X代表氮等; Y和Z代表每个CH,氮等; A和E代表每个亚甲基等; D代表苯基等; G代表共价键等。 ),具有血管紧张素II拮抗作用并可用于预防或治疗高血压,充血性心力衰竭,慢性肾衰竭,醛固酮增多症,眼内压升高等。
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公开(公告)号:EP1157694A4
公开(公告)日:2002-08-28
申请号:EP99973258
申请日:1999-11-30
发明人: TANIKAWA KEIZO , TSURUZOE NOBUTOMO , SHUDO NORIMASA , YAMASHITA TORU , ISHIWATA NORIHISA , KIDO HIDEAKI , EBISU HAJIME , HAYASHI KAZUTAKA , KUBO YOSHIJI , NAKAMURA NORIFUMI
IPC分类号: A61K31/50 , A61K31/501 , A61P15/10
CPC分类号: A61K31/501 , A61K31/50
摘要: An erectile dysfunction remedy which comprises as the active ingredient a 3(2H)-pyridazinone derivative represented by formula (I) or a pharmacologically acceptable salt thereof, wherein the symbols each is the same as defined in the description.
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公开(公告)号:EP0742211A4
公开(公告)日:1997-03-26
申请号:EP95906505
申请日:1995-01-24
IPC分类号: C07D237/22 , C07D401/12 , A61K31/50
CPC分类号: C07D401/12 , C07D237/22
摘要: A pyridazinone derivative represented by general formula (I) and an antithrombocytic agent containing the same, wherein R represents hydrogen or C1-C4 alkyl; X represents hydrogen, chlorine or bromine; An represents pyridyl or phenyl substituted by OR1 (R1 representing hydrogen or C¿1?-C4 alkyl) and A (representing hydrogen, halogen, C1-C4 alkyl or OR?2 (R2¿ representing hydrogen or C¿1?-C4 alkyl)); Y represents C1-C8 alkylene wherein one carbon atom on the straight chain is substituted by one OR?1¿ group (R1 being as defined as above); and Z?1 and Z2¿ represent each independently hydrogen, halogen, C¿1?-C4 alkyl or OR?1 (R1¿ being as defined above). This compound has a potent antithrombocytic activity and an excellent safety and is used as the active ingredient of a preventive or remedy for various thrombotic diseases.
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公开(公告)号:EP0987253A4
公开(公告)日:2000-03-22
申请号:EP96933613
申请日:1996-10-11
IPC分类号: A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/47 , A61K31/495 , A61P7/02 , A61P9/08 , A61P9/10 , C07D231/12 , C07D231/14 , C07D231/20 , C07D231/22 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D401/12
CPC分类号: C07D231/12 , C07D231/14 , C07D231/20 , C07D231/22 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04
摘要: Pyrazolone derivatives represented by general formula (I) or salts thereof which have antiplatelet aggregation effects and thus are useful as a preventive or remedy for various thrombotic diseases. In said formula (I) X?1 and X2¿ represents (a), wherein A represents cyano, cyano(C¿1-4? alkyl), amino, amino-(C1-4 alkyl), amidino, guanidino, etc.; and R?1 and R2¿ independently represents each hydrogen, halogeno, C¿1-6? alkyl, etc.; another of X?1 and X2¿ represents C¿1-6? alkyl, C3-6 alkenyl, aryl(C1-4 alkyl) or aryl; one of Y?1 and Y2¿ represents (b), wherein Q represents oxygen or sulfur; Z1 represents oxygen, -NR7- or -CHR7-; Z2 represents cyclic C¿3-7? alkylene, C1-3 alkylene, -CH2CO-, -CH2CH2CO-, etc.; Z?3¿ represents oxygen, sulfur, sulfinyl, sulfonyl, etc.; Z4 represents C¿1-3? alkylene, etc.; and Z?5¿ represents carboxyl, etc.; and another of Y?1 and Y2¿ represents D-E-, wherein E represents a bond, C¿1-4? alkylene, phenylene, etc.; and D represents hydrogen, C1-6 alkyl, etc.
摘要翻译: 由通式(I)表示的吡唑啉酮衍生物或其盐具有抗血小板聚集作用,因此可用作各种血栓性疾病的预防剂或治疗剂。 在所述式(I)中,X 1和X 2代表(a),其中A代表氰基,氰基(C 1-4 - 烷基),氨基,氨基 - (C 1-4烷基),脒基,胍基等 ; R 1和R 2'分别代表氢,卤素,C 1-6 - 烷基等; 另一个X 1和X 2代表C 1 -6? 烷基,C 3-6链烯基,芳基(C 1-4烷基)或芳基; Y 1和Y 2'中的一个代表(b),其中Q代表氧或硫; Z1代表氧,-NR7-或-CHR7-; Z2表示环C 3-7 - 亚烷基,C 1-3亚烷基,-CH 2 CO - , - CH 2 CH 2 CO-等; Z 3表示氧,硫,亚磺酰基,磺酰基等; Z4代表C1-3? 亚烷基等; Z 5表示羧基等。 Y 1和Y 2'中的另一个表示D-E-,其中E表示键,C 1-4 - 亚烷基,亚苯基等; D表示氢,C 1-6烷基等
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公开(公告)号:EP0716091A4
公开(公告)日:1997-01-15
申请号:EP94924399
申请日:1994-08-22
发明人: SUZUKI HITOMI , MAEDA KOUICHI , TANIKAWA KEIZO , MIYAJI KATSUAKI
CPC分类号: A61K49/04 , C07F9/94 , Y10S424/90
摘要: A tris(substituted phenyl)bismuth derivative represented by general formula (I) and, if any, a pharmaceutically acceptable salt thereof, wherein X represents Y -NR R [wherein Y represents -SO2- or -C(=O)-; and R and R represent each independently hydrogen, C1-C4 alkyl or A-Z (wherein A represents alkylene which has 2-6 carbon atoms in total and may have a branch having at least two carbon atoms, and Z represents OR (wherein R represents SiR R R (wherein R , R and R represent each independently C1-C4 alkyl or phenyl), hydrogen or C1-C4 alkyl) or NR R (wherein R and R represent each independently hydrogen or C1-C4 alkyl)), provided the case where R and R are both hydrogen atoms is excepted], -O-CHR -OR (wherein R represents C1-C4 alkyl, and R is as defined above) or Y -A-Z [wherein Y represents O, -S(O)n- (wherein n represents an integer of 0 or 2) or -NR - (wherein R is as defined above), and A and Z are each as defined above]; and X and X represent each independently hydrogen or any substituent defined above with respect to X . This compound has an excellent performance as a radio-logical contrast medium and is useful as an X-ray contrast medium for injecting into a blood vessel, urinary tract, and so forth.
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