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    Carbodiimide derivative
    1.
    发明公开
    Carbodiimide derivative 失效
    碳二亚胺衍生物

    公开(公告)号：EP0718300A1

    公开(公告)日：1996-06-26

    申请号：EP95309433.1

    申请日：1995-12-22

    申请人： NISSHINBO INDUSTRIES, INC.

    发明人： Takenishi, Soichiro ,  Suzuki, Osamu ,  Yokomizo, Hirohiko ,  Ichihara, Tatsuo ,  Masuda, Gen ,  Shiohata, Namiko ,  Komiya, Kazuko

    IPC分类号： C07D495/04 ,  G01N33/53

    CPC分类号： C07D495/04 ,  G01N33/532

    摘要： A carbodiimide derivative of the formula:

            W 1 -X-N=C=N-Y-W 2 -Z


    wherein W 1 is an aliphatic hydrocarbon group, a substituted or unsubstituted aryl group, a heteroaryl group, a tertiary amino group or a tertiary or quaternary ammonium group; -W 2 -Z is a quaternary ammonium group; X and Y are each independently a single bond or an alkylene group; and Z is a biotin group as defined herein. The derivative is useful as a labelling reagent for introducing a biotin group into a nucleic acid or a protein.

    摘要翻译： 下式的碳二亚胺衍生物：W1-X-N = C = N-Y-W2-Z其中W1是脂族烃基，取代或未取代的芳基，杂芳基，叔氨基或叔或季铵基团; -W2-Z是季铵基团; X和Y各自独立地为单键或亚烷基; 并且Z是如本文所定义的生物素基团。 该衍生物可用作将生物素基团导入核酸或蛋白质的标记试剂。