公开(公告)号：EP0643075A4

公开(公告)日：1997-02-26

申请号：EP94907668

申请日：1994-02-21

申请人： NISSIN FOOD PRODUCTS LTD

发明人： NAKANO SHIGERU ,  MABUCHI TOSHIYUKI ,  TADA MIKI ,  TAODA YASUO ,  SUGINO DAN ,  KONO YOSHIO ,  NISHIMURA KAORU ,  OKUSHIMA MINORU

IPC分类号： A61K38/55 ,  A61K38/00 ,  A61P29/00 ,  A61P43/00 ,  C07K14/00 ,  C07K14/81 ,  C12N1/21 ,  C12N9/99 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02 ,  C12R1/19

CPC分类号： C07K14/811 ,  A61K38/00

摘要： A novel peptide having an elastase inhibitor activity and being useful as a remedy or preventive for diseases caused by elastase is produced by partially modifying the constitutive amino acid of HI-8 present on the C-terminal side of a human urine trypsin inhibitor and having a trypsin inhibitor activity. The invention also provides a gene coding for the peptide, a plasmid containing the gene, a recombinant microbe holding the plasmid, and a process for producing the peptide by using the recombinant microbe.