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    THERAPEUTIC AGENT FOR FIBROID LUNG
    3.
    发明公开
    THERAPEUTIC AGENT FOR FIBROID LUNG 审中-公开
    用于纤维肺的治疗剂

    公开(公告)号：EP3025731A1

    公开(公告)日：2016-06-01

    申请号：EP15202384.2

    申请日：2009-03-16

    申请人： NITTO DENKO CORPORATION

    发明人： Niitsu, Yoshiro ,  Takimoto, Rishu

    IPC分类号： A61K47/10 ,  A61K9/127 ,  A61K31/7088 ,  A61K48/00 ,  A61P11/00

    摘要： Disclosed are: a substance transfer carrier to an extracellular matrix-producing cell in the lung, which comprises a retinoid; a therapeutic agent for fibroid lung, which utilized the carrier; and a preparation kit of the therapeutic agent.

    摘要翻译： 本发明公开了一种向肺内产生细胞外基质的细胞的物质转移载体，其包含类视色素; 一种利用载体的纤维瘤肺治疗剂; 和治疗剂的制备试剂盒。

    Drug carrier and drug carrier kit for inhibiting fibrosis
    4.
    发明公开
    Drug carrier and drug carrier kit for inhibiting fibrosis 审中-公开
    用于抑制纤维化的药物载体和药物载体试剂盒

    公开(公告)号：EP2730277A2

    公开(公告)日：2014-05-14

    申请号：EP13193438.2

    申请日：2005-12-22

    申请人： NITTO DENKO CORPORATION

    发明人： Niitsu, Yoshiro ,  Kato, Junji ,  Sato, Yasushi

    IPC分类号： A61K9/107 ,  A61K9/127 ,  A61K31/7088 ,  A61K31/07 ,  A61K45/06 ,  A61K9/50 ,  A61K9/51 ,  A61P1/16 ,  A61P1/18 ,  A61P43/00

    摘要： A stellate cell-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent; a drug delivery method with the use of the same; a drug containing the same; and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as vitamin A or a vitamin A analog or encapsulating the same in the drug carrier, a drug for therapeutic use can be delivered specifically to astrocytes. As a result, a stellate cell-related disease can be efficiently and effectively inhibited or prevented while minimizing side effects. As the drug inhibiting the activity or growth of stellate cells, for example, a siRNA against HSP47 which is a collagen-specific molecule chaperone may be encapsulated in the drug carrier. Thus, the secretion of type I to type IV collagens can be inhibited at the same time and, in its turn, fibrosis can be effectively inhibited.

    摘要翻译： 含有类维生素A衍生物和/或维生素A类似物作为成分的星状细胞特异性药物载体; 使用它的药物递送方法; 含有它的药物; 以及使用该药物的治疗方法。 通过将药物载体与类视黄醇衍生物如维生素A或维生素A类似物结合或将其包封在药物载体中，用于治疗用途的药物可以特异性递送至星形胶质细胞。 结果，可以有效地抑制或预防星状细胞相关疾病，同时使副作用最小化。 作为抑制星状细胞活性或生长的药物，例如，可以将针对作为胶原特异性分子伴侣的HSP47的siRNA包封在药物载体中。 因此，可以同时抑制I型向IV型胶原的分泌，进而可以有效抑制纤维化。