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公开(公告)号：EP3434773A2
公开(公告)日：2019-01-30
申请号：EP18191694.1
申请日：2010-12-08
发明人： Jin, Xiaomei , Yu, Lei , Takahashi, Hirokazu , Tanaka, Yasunobu , Niitsu, Yoshiro , Feinstein, Elena , Avkin-Nachum, Sharon , Kalinski, Hagar , Mett, Igor , Erlich, Shai , Squiers, Elizabeth, C. , Chen, Ning
IPC分类号： C12N15/113 , A61K31/713 , C07H21/02
摘要： Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.
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公开(公告)号：EP3012324A2
公开(公告)日：2016-04-27
申请号：EP15193839.6
申请日：2010-12-08
发明人： Jin, Xiaomei , Yu, Lei , Takahashi, Hirokazu , Tanaka, Yasunobu , Niitsu, Yoshiro , Feinstein, Elena , Avkin-Nachum, Sharon , Kalinski, Hagar , Mett, Igor , Erlich, Shai , Squiers, Elizabeth C. , Chen, Ning
IPC分类号： C12N15/113 , A61K31/713 , C07H21/02
CPC分类号： C12N15/113 , A61K31/713 , C12N2310/11 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/32 , C12N2310/321 , C12N2310/33 , C12N2310/531 , C12N2320/30 , C12N2310/3521
摘要： Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.
摘要翻译： 本文提供了用于调节靶基因，特别是热休克蛋白47（hsp47）表达的组合物，方法和试剂盒。 组合物，方法和试剂盒可以包括核酸分子（例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）或短发夹RNA（shRNA） ）），其调节编码hsp47的基因，例如编码人类hsp47的基因。 本文公开的组合物和方法还可用于治疗与hsp47相关的病症和病症，例如肝纤维化，肺纤维化，腹膜纤维化和肾纤维化。
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公开(公告)号：EP3489220A1
公开(公告)日：2019-05-29
申请号：EP18200656.9
申请日：2013-06-07
发明人： Payne, Joseph E. , Gaudette, John A. , Hou, Zheng , Ahmadian, Mohammad , Yu, Lei , Knopov, Victor , Akopian, Violetta , Karmali, Priya , Witte, Richard P. , Safarzadeh, Neda , Ying, Wenbin , Zhang, Jun
IPC分类号： C07C271/16 , C07D333/40 , C07C317/44 , C07C321/14 , C07C333/04 , C07C235/08 , C07C237/08 , C07D207/16 , A61K47/16 , A61K47/18 , A61K47/22
摘要： The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.
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公开(公告)号：EP3012324A3
公开(公告)日：2016-07-06
申请号：EP15193839.6
申请日：2010-12-08
发明人： Jin, Xiaomei , Yu, Lei , Takahashi, Hirokazu , Tanaka, Yasunobu , Niitsu, Yoshiro , Feinstein, Elena , Avkin-Nachum, Sharon , Kalinski, Hagar , Mett, Igor , Erlich, Shai , Squiers, Elizabeth C. , Chen, Ning
IPC分类号： C12N15/113 , A61K31/713 , C07H21/02
CPC分类号： C12N15/113 , A61K31/713 , C12N2310/11 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/32 , C12N2310/321 , C12N2310/33 , C12N2310/531 , C12N2320/30 , C12N2310/3521
摘要： Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.
摘要翻译： 本文提供用于调节靶基因，特别是热休克蛋白47（hsp47）的表达的组合物，方法和试剂盒。 组合物，方法和试剂盒可以包括核酸分子（例如，短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）或短发夹RNA（shRNA ）），其调节编码hsp47的基因，例如编码人hsp47的基因。 本文公开的组合物和方法也可用于治疗与hsp47相关的病症和病症，例如肝纤维化，肺纤维化，腹膜纤维化和肾纤维化。
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5.发明授权
公开(公告)号：EP2253718B1
公开(公告)日：2012-07-04
申请号：EP10075260.9
申请日：2003-12-04
发明人： Yu, Lei , Matsumoto, Kenji , Ji, Shouping , Du, Fusheng
CPC分类号： C12N15/87 , A61K47/644 , A61K47/645 , A61K48/00
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公开(公告)号：EP2858974A1
公开(公告)日：2015-04-15
申请号：EP13729241.3
申请日：2013-06-07
发明人： Payne, Joseph E. , Gaudette, John, A. , Hou, Zheng , Ahmadian, Mohammad , Yu, Lei , Knopov, Victor , Akopian, Violetta , Karmali, Priya , Witte, Richard P. , Safarzadeh, Neda , Ying, Wenbin , Zhang, Jun
IPC分类号： C07C271/16 , C07D333/40 , C07C317/44 , C07C321/14 , C07C333/04 , C07C235/08 , C07C237/08 , C07D207/16 , A61K47/16 , A61K47/18 , A61K47/22
CPC分类号： A61K47/20 , A61K9/1272 , A61K47/14 , A61K47/18 , A61K47/22 , C07C235/08 , C07C237/08 , C07C237/16 , C07C271/16 , C07C317/44 , C07C323/60 , C07C333/04 , C07D207/16 , C07D333/38 , C07D333/40 , Y10T428/2998
摘要： The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.
摘要翻译： 描述是针对可电离的用于增强治疗剂递送到脂质体的脂类。
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公开(公告)号：EP2253718A2
公开(公告)日：2010-11-24
申请号：EP10075260.9
申请日：2003-12-04
发明人： Yu, Lei , Matsumoto, Kenji , Ji, Shouping , Du, Fusheng
CPC分类号： C12N15/87 , A61K47/644 , A61K47/645 , A61K48/00
摘要： The present invention is related to a method for introducing biomolecules, such as nucleic acids, into cells by culturing cells on a solid surface which is coated with a transfection reagents and biomolecules.
摘要翻译： 本发明涉及通过将细胞在用转染试剂和生物分子包被的固体表面上培养来将生物分子例如核酸引入细胞的方法。
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公开(公告)号：EP2858974B1
公开(公告)日：2018-10-17
申请号：EP13729241.3
申请日：2013-06-07
发明人： Payne, Joseph E. , Gaudette, John, A. , Hou, Zheng , Ahmadian, Mohammad , Yu, Lei , Knopov, Victor , Akopian, Violetta , Karmali, Priya , Witte, Richard P. , Safarzadeh, Neda , Ying, Wenbin , Zhang, Jun
IPC分类号： C07C271/16 , C07D333/40 , C07C317/44 , C07C321/14 , C07C333/04 , C07C235/08 , C07C237/08 , C07D207/16 , A61K47/16 , A61K47/18 , A61K47/22
CPC分类号： A61K47/20 , A61K9/1272 , A61K47/14 , A61K47/18 , A61K47/22 , C07C235/08 , C07C237/08 , C07C237/16 , C07C271/16 , C07C317/44 , C07C323/60 , C07C333/04 , C07D207/16 , C07D333/38 , C07D333/40 , Y10T428/2998
摘要： The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.
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公开(公告)号：EP2206736B1
公开(公告)日：2012-02-08
申请号：EP10004160.7
申请日：2006-12-01
发明人： Yu, Lei , Zhao, Gang , Van, Sang , Das, Sanjib Kumar , Feng, Zhongling , Fu, Xiaoli , Wang, Xinghe
IPC分类号： C08G69/10
CPC分类号： A61K47/42 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K47/56 , A61K47/62 , A61K47/64 , A61K47/645 , A61K49/0041 , A61K49/0056 , A61K49/146 , C08G69/10 , C08G69/48
摘要： Various biodegradable polyglutamate-amino acids comprising recurring units of the general Formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.
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公开(公告)号：EP2077290A1
公开(公告)日：2009-07-08
申请号：EP09004686.3
申请日：2006-12-01
发明人： Yu, Lei , Zhao, Gang , Van, Sang , Das, Sanjib Kumar , Feng, Zhongling , Fu, Xiaoli , Wang, Xinghe
IPC分类号： C08G69/10
CPC分类号： A61K47/42 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K47/56 , A61K47/62 , A61K47/64 , A61K47/645 , A61K49/0041 , A61K49/0056 , A61K49/146 , C08G69/10 , C08G69/48
摘要： Various biodegradable polyglutamate-amino acids comprising recurring units of the general Formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.
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