公开(公告)号：EP0200508A3

公开(公告)日：1987-07-08

申请号：EP86303170

申请日：1986-04-25

申请人： NITTO ELECTRIC INDUSTRIAL CO., LTD. ,  SUNSTAR INC.

发明人： Inoue, Yuichi ,  Horiuchi, Tetuo ,  Hasegawa, Kenji ,  Nakashima, Koichi ,  Ysuyoshi, Takashi

IPC分类号： A61K09/70 ,  A61L15/06

CPC分类号： A61K9/006 ,  A61L15/225 ,  C08L31/04

摘要： A polycarboxylic acid or anhydride, e.g. acrylic or methacrylic acid polymer or maleic anhydride polymer, is mixed with a vinyl acetate polymer preferably of viscosity-average molecular weight of at least 60,000, and optionally with a base capable of neutralising the acid or anhydride, e.g. a salt of a metal or a weak acid. The mixture in a mutual organic or aqueous organic solvent is cast on a sheet base and dried and peeled off to form an oral bandage, which may include a soft film support. The bandage shows strong adhesion for a period of at least 3 hours to the oral mucosa or teeth. A topical drug can be incorporated in the adhesive bandage, to form an oral pharmaceutical preparation from which the drug is gradually released.

公开(公告)号：EP0200508B1

公开(公告)日：1991-10-02

申请号：EP86303170.4

申请日：1986-04-25

申请人： NITTO DENKO CORPORATION ,  SUNSTAR INC.

发明人： Inoue, Yuichi ,  Horiuchi, Tetuo ,  Hasegawa, Kenji ,  Nakashima, Koichi ,  Ysuyoshi, Takashi

IPC分类号： A61K9/70 ,  A61L15/16

CPC分类号： A61K9/006 ,  A61L15/225 ,  C08L31/04

公开(公告)号：EP0200508A2

公开(公告)日：1986-12-10

申请号：EP86303170.4

申请日：1986-04-25

申请人： NITTO DENKO CORPORATION ,  SUNSTAR INC.

发明人： Inoue, Yuichi ,  Horiuchi, Tetuo ,  Hasegawa, Kenji ,  Nakashima, Koichi ,  Ysuyoshi, Takashi

IPC分类号： A61K9/70 ,  A61L15/16

摘要： A polycarboxylic acid or anhydride, e.g. acrylic or methacrylic acid polymer or maleic anhydride polymer, is mixed with a vinyl acetate polymer preferably of viscosity-average molecular weight of at least 60,000, and optionally with a base capable of neutralising the acid or anhydride, e.g. a salt of a metal or a weak acid. The mixture in a mutual organic or aqueous organic solvent is cast on a sheet base and dried and peeled off to form an oral bandage, which may include a soft film support.
The bandage shows strong adhesion for a period of at least 3 hours to the oral mucosa or teeth.
A topical drug can be incorporated in the adhesive bandage, to form an oral pharmaceutical preparation from which the drug is gradually released.

摘要翻译： 多元羧酸或酸酐，例如 丙烯酸或甲基丙烯酸聚合物或马来酸酐聚合物）与优选粘度平均分子量至少为60,000的乙酸乙烯酯聚合物混合，并任选与能够中和酸或酸酐的碱（例如乙酸乙烯酯）混合。 金属盐或弱酸。 将在相互有机或含水有机溶剂中的混合物浇铸在片基上并干燥并剥离以形成口服绷带，其可包括软膜支撑物。 绷带在口腔粘膜或牙齿上显示出至少3小时的强粘附力。 可以将外用药物掺入粘性绷带中，形成药物逐渐释放的口服药物制剂。