公开(公告)号：EP1366767A4

公开(公告)日：2007-06-27

申请号：EP02712376

申请日：2002-02-15

申请人： NOF CORP ,  TOA PHARMACEUTICAL CO LTD

发明人： SAITOH KOUICHI ,  KISHIMOTO YOKO ,  TOKUYAMA SATORU ,  OGURO SUSUMU ,  HANAZOME ISAO ,  OKAMOTO TOMOYUKI ,  KASAMA TOSHIO

IPC分类号： A61K9/10 ,  A01N25/04 ,  A01N25/10 ,  A01N25/30 ,  A01N43/90 ,  A61K9/00 ,  A61K31/522 ,  A61K47/06 ,  A61K47/32 ,  A61P27/02 ,  A61P31/12

CPC分类号： A61K31/522 ,  A61K9/0048

摘要： An ophthalmic aqueous suspension preparation to serve as a cure for corneal herpes infection contains 9-Ä(2-hydroxyethoxy)methylÜguanine as an active ingredient and exhibits an improved stability. Specifically, the ophthalmic aqueous suspension preparation contains 0.2 to 5% by weight of 9-Ä(2-hydroxyethoxy)methylÜguanine or a pharmaceutically acceptable salt thereof, 0.05 to 1% by weight of a partially saponified product of polyvinyl acetate, and 0.01 to 1% by weight of a nonionic surfactant and has a pH of 6 to 8. Preferably, the fine crystals have a short axis of 50 mu m or less and a long axis of 70 mu m or less in length and have a ratio of the long axis to the short axis of 10:1 or less.