公开(公告)号：EP2781507B1

公开(公告)日：2017-03-22

申请号：EP12850198.8

申请日：2012-11-09

申请人： NOF CORPORATION ,  NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

发明人： TANGE, Kota ,  ARAI, Masaya ,  KUBO, Kazuhiro ,  AKITA, Hidetaka ,  HARASHIMA, Hideyoshi ,  HATAKEYAMA, Hiroto ,  ISHIBA, Ryohei ,  UKAWA, Masami ,  TANAKA, Hiroki

IPC分类号： C07C323/25 ,  A61K47/20 ,  A61K47/44 ,  A61K48/00

CPC分类号： C12N15/88 ,  A61K9/0019 ,  A61K9/1271 ,  A61K9/1272 ,  A61K47/20 ,  A61K47/22 ,  C07C323/25 ,  C07C2601/16 ,  C07D311/72

公开(公告)号：EP2781507A1

公开(公告)日：2014-09-24

申请号：EP12850198.8

申请日：2012-11-09

申请人： NOF Corporation ,  National University Corporation Hokkaido University

发明人： TANGE, Kota ,  ARAI, Masaya ,  KUBO, Kazuhiro ,  AKITA, Hidetaka ,  HARASHIMA, Hideyoshi ,  HATAKEYAMA, Hiroto ,  ISHIBA, Ryohei ,  UKAWA, Masami ,  TANAKA, Hiroki

IPC分类号： C07C323/25 ,  A61K47/20 ,  A61K47/44 ,  A61K48/00

CPC分类号： C12N15/88 ,  A61K9/0019 ,  A61K9/1271 ,  A61K9/1272 ,  A61K47/20 ,  A61K47/22 ,  C07C323/25 ,  C07C2601/16 ,  C07D311/72

摘要： Provided is a cationic lipid capable of achieving high intracellular expression efficiency when used as a nucleic acid delivery carrier.
A compound represented by the formula (1)

wherein X a and X b are each independently X 1 or X 2 ;


s is 1 or 2,
R 4 is an alkyl group having 1 - 6 carbon atoms,
n a and n b are each independently 0 or 1,
R 1a and R 1b are each independently an alkylene group having 1 - 6 carbon atoms,
R 2a and R 2b are each independently an alkylene group having 1 - 6 carbon atoms,
Y a and Y b are each independently an ester bond, an amide bond, a carbamate bond, an ether bond or a urea bond, and
R 3a and R 3b are each independently a sterol residue, a liposoluble vitamin residue or an aliphatic hydrocarbon group having 12 - 22 carbon atoms.