公开(公告)号：EP4368655A1

公开(公告)日：2024-05-15

申请号：EP22837711.5

申请日：2022-07-06

申请人： NOF Corporation ,  Tokyo Institute of Technology

发明人： OGI, Koichi ,  MICHINISHI, Junya ,  OHTAKE, Tomoyuki ,  IIZUKA, Muneaki ,  NISHIYAMA, Nobuhiro ,  TAKEMOTO, Hiroyasu ,  MIURA, Yutaka ,  NOMOTO, Takahiro ,  MATSUI, Makoto ,  SUNG, Yi-Jung ,  TOYODA, Masahiro ,  GHASEMIZADEH, Aria

IPC分类号： C08G69/10 ,  A61K47/34

CPC分类号： A61K47/34 ,  C08G69/10

摘要： The present invention provides a highly pure pH-responsive polymer represented by the following formula (I), a production method thereof, and the like:

(in the formula (I), each symbol is as described in the specification).

公开(公告)号：EP4368657A1

公开(公告)日：2024-05-15

申请号：EP22837710.7

申请日：2022-07-06

申请人： NOF Corporation ,  Tokyo Institute of Technology

发明人： OGI, Koichi ,  MICHINISHI, Junya ,  OHTAKE, Tomoyuki ,  NISHIYAMA, Nobuhiro ,  TAKEMOTO, Hiroyasu ,  MIURA, Yutaka ,  NOMOTO, Takahiro ,  MATSUI, Makoto ,  SUNG, Yi-Jung ,  TOYODA, Masahiro ,  GHASEMIZADEH, Aria

IPC分类号： C08G69/42 ,  A61K9/127 ,  A61K9/16 ,  A61K31/7088 ,  A61K38/02 ,  A61K45/00 ,  A61K47/24 ,  A61K47/34 ,  A61K47/44 ,  A61P35/00 ,  A61P43/00 ,  C07K16/28 ,  C12N15/113 ,  C12N15/115

CPC分类号： A61K9/127 ,  A61K9/16 ,  A61K31/7088 ,  A61K38/02 ,  A61K45/00 ,  A61K47/24 ,  A61K47/34 ,  A61K47/44 ,  A61P35/00 ,  A61P43/00 ,  C07K16/28 ,  C08G69/42 ,  C12N15/115 ,  C12N15/113

摘要： The present invention provides a pH-responsive lipid derivative represented by a structure represented by the following formula (i):

(in the above-mentioned formula, each symbol is as described in the specification), and a pH-responsive transport carrier which is useful as a transport carrier for safely and efficiently performing delivery of low-molecular-weight drugs and the like to tumor tissues.