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1.发明公开CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF THE RETINOIC ACID-RELATED ORPHAN RECEPTOR ALPHA (ROR-ALPHA) 审中-公开晶体结构配体结合视黄酸相关的孤儿受体α遗产（ROR ALPHA）
公开(公告)号：EP1501867A1
公开(公告)日：2005-02-02
申请号：EP03725112.1
申请日：2003-04-28
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： C07K14/705
CPC分类号： C07K14/70567 , C07K2299/00
摘要： The present invention relates RORα in crystallized form and methods for the preparation thereof. The invention also provides a three-dimensional model RORα and means for the design of RORα modulators. Ligands binding to RORα are also provided.
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2.发明公开QUINAZOLINE DERIVATIVES WHICH PROMOTE THE RELEASE OF PARATHYROID HORMONE 有权Chinazolines衍生促进PARATHYROIDMSHORMONEN的释放
公开(公告)号：EP1401451A2
公开(公告)日：2004-03-31
申请号：EP02758236.0
申请日：2002-06-14
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： A61K31/517 , A61P5/18 , A61P19/10 , C07D239/82
CPC分类号： C07D401/06 , C07D213/88 , C07D239/74 , C07D239/78 , C07D239/82 , C07D239/84 , C07D265/36 , C07D401/12 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D417/06
摘要： Use of compound of formula (I), wherein (a) is (b) or (c) and wherein the symbols are as defined, or a pharmaceutically-acceptable and-cleavable ester, or acid addition salt thereof, for the preparation of a medicament for promoting the release of parathyroid hormone, e.g. for preventing or treating bone conditions which are associated with increased calcium depletion or resorption or in which stimulation of bone formation and calcium fixation in the bone is desirable.
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3.发明授权
公开(公告)号：EP1401451B1
公开(公告)日：2009-11-11
申请号：EP02758236.0
申请日：2002-06-14
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： A61K31/517 , A61P5/18 , A61P19/10 , C07D239/82
CPC分类号： C07D401/06 , C07D213/88 , C07D239/74 , C07D239/78 , C07D239/82 , C07D239/84 , C07D265/36 , C07D401/12 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D417/06
摘要： Use of compound of formula (I), wherein (a) is (b) or (c) and wherein the symbols are as defined, or a pharmaceutically-acceptable and-cleavable ester, or acid addition salt thereof, for the preparation of a medicament for promoting the release of parathyroid hormone, e.g. for preventing or treating bone conditions which are associated with increased calcium depletion or resorption or in which stimulation of bone formation and calcium fixation in the bone is desirable.
摘要翻译： 其中（a）是（b）或（c）且其中符号如上所定义的式（I）化合物或其药学上可接受的且可裂解的酯或其酸加成盐用于制备 用于促进甲状旁腺激素释放的药物，例如 用于预防或治疗与钙缺乏或再吸收增加相关的骨骼病症，或者其中需要刺激骨骼形成和骨骼中的钙固定。
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4.发明授权DERIVATIVES OF ARYL-QUINAZOLINE/ARYL-2AMINO-PHENYL METHANONE WHICH PROMOTE THE RELEASE OF PARATHYROID HORMONE 有权DORIVATE VON ARYL-CHINAZOLIN / ARYL-2AMINO-PHENYL-METHANONZURFÖRDERUNGDER FREISETZUNG VON PARATHORMON
公开(公告)号：EP1585521B8
公开(公告)日：2009-03-25
申请号：EP03813593.5
申请日：2003-12-22
申请人： NOVARTIS AG , Novartis Pharma GmbH
发明人： ALTMANN, Eva , BEERLI, René , GERSPACHER, Marc , RENAUD, Johanne , WEILER, Sven , WIDLER, Leo
IPC分类号： A61K31/498 , C07D403/06 , C07D239/82 , C07D403/10 , C07D409/06 , C07D405/06 , C07D417/06 , C07D401/06 , C07D413/06 , C07D401/12 , C07D239/78 , C07C49/84 , A61P5/18
CPC分类号： C07C17/12 , C07C45/30 , C07C205/37 , C07C205/44 , C07C205/45 , C07C225/22 , C07C229/18 , C07C255/24 , C07C255/25 , C07C317/18 , C07C317/32 , C07C323/25 , C07C2601/02 , C07D213/64 , C07D239/82 , C07D239/93 , C07D317/58 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/10 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07C25/18 , C07C47/277
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5.发明授权DERIVATIVES OF ARYL-QUINAZOLINE/ARYL-2AMINO-PHENYL METHANONE WHICH PROMOTE THE RELEASE OF PARATHYROID HORMONE 有权EUROPE激素芳基 - 喹唑啉/芳基-2-氨基 - 苯基甲酮ZURFÖRDERUNG释放衍生物
公开(公告)号：EP1585521B1
公开(公告)日：2008-06-18
申请号：EP03813593.5
申请日：2003-12-22
申请人： Novartis AG , Novartis Pharma GmbH
发明人： ALTMANN, Eva , BEERLI, René , GERSPACHER, Marc , RENAUD, Johanne , WEILER, Sven , WIDLER, Leo
IPC分类号： A61K31/498 , C07D403/06 , C07D239/82 , C07D403/10 , C07D409/06 , C07D405/06 , C07D417/06 , C07D401/06 , C07D413/06 , C07D401/12 , C07D239/78 , C07C49/84 , A61P5/18
CPC分类号： C07C17/12 , C07C45/30 , C07C205/37 , C07C205/44 , C07C205/45 , C07C225/22 , C07C229/18 , C07C255/24 , C07C255/25 , C07C317/18 , C07C317/32 , C07C323/25 , C07C2601/02 , C07D213/64 , C07D239/82 , C07D239/93 , C07D317/58 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/10 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07C25/18 , C07C47/277
摘要： A compound of formula (I): wherein R1, R2, R3 and Y are as defined herein, or a pharmaceutically-acceptable and -cleavable ester, or acid addition salt thereof, useful for promoting the release of parathyroid hormone, e.g. for preventing or treating bone conditions which are associated with increased calcium depletion or resorption or in which stimulation of bone formation and calcium fixation in the bone is desirable.
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6.发明公开DERIVATIVES OF ARYL-QUINAZOLINE/ARYL-2AMINO-PHENYL METHANONE WHICH PROMOTE THE RELEASE OF PARATHYROID HORMONE 有权EUROPE激素芳基 - 喹唑啉/芳基-2-氨基 - 苯基甲酮ZURFÖRDERUNG释放衍生物
公开(公告)号：EP1585521A2
公开(公告)日：2005-10-19
申请号：EP03813593.5
申请日：2003-12-22
申请人： Novartis AG , Novartis Pharma GmbH
发明人： ALTMANN, Eva , BEERLI, René , GERSPACHER, Marc , RENAUD, Johanne , WEILER, Sven , WIDLER, Leo
IPC分类号： A61K31/498 , C07D403/06 , C07D239/82 , C07D403/10 , C07D409/06 , C07D405/06 , C07D417/06 , C07D401/06 , C07D413/06 , C07D401/12 , C07D239/78 , C07C49/84 , A61P5/18
CPC分类号： C07C17/12 , C07C45/30 , C07C205/37 , C07C205/44 , C07C205/45 , C07C225/22 , C07C229/18 , C07C255/24 , C07C255/25 , C07C317/18 , C07C317/32 , C07C323/25 , C07C2601/02 , C07D213/64 , C07D239/82 , C07D239/93 , C07D317/58 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/10 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07C25/18 , C07C47/277
摘要： A compound of formula (I): wherein R1, R2, R3 and Y are as defined herein, or a pharmaceutically-acceptable and -cleavable ester, or acid addition salt thereof, useful for promoting the release of parathyroid hormone, e.g. for preventing or treating bone conditions which are associated with increased calcium depletion or resorption or in which stimulation of bone formation and calcium fixation in the bone is desirable.
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7.发明公开HETEROCYCLIC ORGANIC COMPOUNDS FOR THE TREATMENT OF IN PARTICULAR MELANOMA 审中-公开杂环有机化合物，特别是对黑色素瘤的治疗
公开(公告)号：EP2001864A1
公开(公告)日：2008-12-17
申请号：EP07753076.4
申请日：2007-03-14
IPC分类号： C07D401/04 , C07D401/14 , A61K31/506 , A61P35/00 , A61P25/00 , A61P29/00
CPC分类号： C07D401/04
摘要： The present invention relates to the discovery that certain compounds inhibit, regulate and/or modulate tyrosine and serine/threonine kinase and kinase-like proteins, such as RAF kinase, a serine/threonine kinase that functions in the MAP kinase signaling pathway, and is concerned with compositions which contain these compounds, and methods of using them to treat tyrosine and serine/threonine kinase and kinase-like dependent diseases, such as angiogenesis, cancer and cardiac hypertrophy. (Formula I).
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8.发明公开PHENYLISOQUINOLINE AND PHENYLQUINAZOLINE DERIVATIVES FOR THE TREATMENT OF BONE DISEASES 审中-公开苯基喹啉和苯基喹唑啉衍生物治疗骨病
公开(公告)号：EP2197872A1
公开(公告)日：2010-06-23
申请号：EP08787549.8
申请日：2008-08-28
申请人： Novartis AG
发明人： BEERLI, René
IPC分类号： C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D473/00 , A61P19/00 , A61K31/517 , A61K31/52 , A61K31/4709 , A61K31/4725
CPC分类号： C07D403/04 , C07D401/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D473/00
摘要： The present invention relates to substituted phenylisoquinoline and phenylquinazoline derivatives and to their pharmaceutical uses in preventing or treating bone conditions which are associated with increased calcium depletion or resorption or in which stimulation of bone formation and calcium fixation in the bone is desirable.
摘要翻译： 本发明涉及取代的苯基异喹啉和苯基喹唑啉衍生物以及它们在预防或治疗与钙缺乏或再吸收增加相关的骨病症或其中需要刺激骨形成和骨中钙固定的药物用途。
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9.发明授权BENZOQUINAZOLINE DERIVATIVES AND THEIR USE IN TREATING BONE DISORDERS 有权BENZOCHINAZOLINDERIVATE和它们在骨疾病的治疗
公开(公告)号：EP1917246B1
公开(公告)日：2009-11-11
申请号：EP06776845.7
申请日：2006-08-14
申请人： Novartis AG
发明人： AMMON, Sandra , BEERLI, René , WIDLER, Leo
IPC分类号： C07D217/12 , C07D217/26 , C07D239/70 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D417/06 , C07D417/12 , A61K31/395 , A61K31/435
CPC分类号： C07D409/06 , C07D217/12 , C07D217/26 , C07D239/70 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D417/06 , C07D417/12
摘要： A compound of formula (I) or a pharmaceutically acceptable salt or prodrug ester thereof, wherein the groups R2, R3, R4, Q, X and Y are as defined in the specification, is useful in the treatment of bone conditions related to increased calcium depletion or resorption.
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10.发明公开BENZOQUINAZOLINE DERIVATIVES AND THEIR USE IN TREATING BONE DISORDERS 有权BENZOCHINAZOLINDERIVATE和它们在骨疾病的治疗
公开(公告)号：EP1917246A1
公开(公告)日：2008-05-07
申请号：EP06776845.7
申请日：2006-08-14
申请人： Novartis AG
发明人： AMMON, Sandra , BEERLI, René , WIDLER, Leo
IPC分类号： C07D217/12 , C07D217/26 , C07D239/70 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D417/06 , C07D417/12 , A61K31/395 , A61K31/435
CPC分类号： C07D409/06 , C07D217/12 , C07D217/26 , C07D239/70 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D417/06 , C07D417/12
摘要： A compound of formula (I) or a pharmaceutically acceptable salt or prodrug ester thereof, wherein the groups R2, R3, R4, Q, X and Y are as defined in the specification, is useful in the treatment of bone conditions related to increased calcium depletion or resorption.
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