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公开(公告)号：EP2807143B1
公开(公告)日：2017-08-30
申请号：EP13740873.8
申请日：2013-01-17
IPC分类号： C07C205/16 , C07C209/34 , C07C209/70 , C07C215/28
CPC分类号： C07C209/78 , C07C17/16 , C07C29/00 , C07C29/14 , C07C45/30 , C07C45/64 , C07C67/293 , C07C209/16 , C07C213/08 , C07C215/10 , C07C215/28 , C07C231/12 , C07C303/28 , C07C309/66 , C07C233/47 , C07C22/04 , C07C69/157 , C07C49/82 , C07C33/20
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公开(公告)号：EP2605767B1
公开(公告)日：2016-07-27
申请号：EP11818895.2
申请日：2011-08-22
IPC分类号： A61K31/045 , C07D223/32 , C07C67/08 , C07C37/50 , C07C249/08 , A61P35/00
CPC分类号： C07C43/23 , A61K31/045 , C07B2200/07 , C07C37/50 , C07C39/17 , C07C41/18 , C07C45/30 , C07C45/65 , C07C49/747 , C07C49/753 , C07C67/08 , C07C69/65 , C07C69/734 , C07C213/02 , C07C215/44 , C07C215/64 , C07C249/08 , C07C251/44 , C07C2603/40 , C07D223/32
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3.发明授权MICROENCAPSULATED CATALYST, METHODS OF PREPARATION AND METHODS OF USE THEREOF 有权MIKROVERKAPSELTER KATALYSATOR，SEIN HERSTELLUNGSVERFAHREN SOWIE VERWENDUNG
公开(公告)号：EP1409125B1
公开(公告)日：2016-04-20
申请号：EP02745592.2
申请日：2002-07-09
申请人： Reaxa Limited
发明人： LEY, Steven Victor , RAMARAO, Chandrashekar , SHIRLEY, Ian Malcolm , SMITH, Stephen Christopher , TAPOLCZAY, David Joszef
CPC分类号： B01J31/04 , B01J13/18 , B01J31/06 , B01J31/165 , B01J31/1805 , B01J31/24 , B01J31/28 , B01J35/0013 , B01J37/0219 , B01J2231/32 , B01J2231/341 , B01J2231/4211 , B01J2231/4255 , B01J2231/4261 , B01J2231/643 , B01J2231/645 , B01J2531/82 , C07B37/04 , C07B2200/07 , C07C5/03 , C07C5/08 , C07C17/263 , C07C29/17 , C07C29/48 , C07C41/26 , C07C41/30 , C07C45/30 , C07C45/62 , C07C45/68 , C07C67/31 , C07C67/343 , C07C67/36 , C07C201/12 , C07C209/36 , C07C209/52 , C07C253/30 , C07C2523/44 , C07C2601/14 , Y02P20/582 , C07C49/403 , C07C47/228 , C07C49/84 , C07C49/813 , C07C255/33 , C07C211/47 , C07C211/48 , C07C205/06 , C07C205/35 , C07C205/45 , C07C205/56 , C07C33/26 , C07C31/20 , C07C35/21 , C07C69/732 , C07C43/1782 , C07C43/2055 , C07C43/225 , C07C43/205 , C07C69/76 , C07C33/24 , C07C69/618 , C07C25/18 , C07C15/02 , C07C13/28 , C07C15/18 , C07C33/28
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4.发明公开METHODS OF SYNTHESIS OF INGENOL AND INTERMEDIATES THEREOF 有权VERFAHREN ZUR SYNTHESE VON INGENOL UND ZWISCHENPRODUKTEN DAVON
公开(公告)号：EP3004036A1
公开(公告)日：2016-04-13
申请号：EP14728884.9
申请日：2014-05-28
发明人： BARAN, Phillipe S. , JØRGENSEN, Lars , KUTTRUFF, Christian A. , MCKERRALL, Steven J. , YEH, Chien-Hung
IPC分类号： C07C29/42 , C07C29/00 , C07C35/28 , C07D317/70 , C07C45/30 , C07C45/40 , C07C45/64 , C07C45/65 , C07C45/72 , C07C49/743 , C07C17/02 , C07C49/693 , C07C49/627 , C07C49/727 , C07C47/21
CPC分类号： C07C67/08 , C07C17/02 , C07C29/00 , C07C29/42 , C07C35/28 , C07C45/30 , C07C45/40 , C07C45/64 , C07C45/65 , C07C45/68 , C07C45/72 , C07C49/743 , C07C2602/20 , C07C2603/40 , C07D317/70 , C07F7/1856 , C07C23/28 , C07C49/693 , C07C49/627 , C07C49/727 , C07C47/21
摘要： The present invention relates generally to methods of synthesis of diterpene heterocylic compounds. More particularly, the present invention relates to efficient methods of synthesis of ingenol (Formula (21), CAS 30220-46-3), from a compound of formula (1). The present invention also provides for various advantageous intermediates along the synthetic route of ingenol. Efficient synthesis of ingenol is important in the design and synthesis of related analogues, such as ingenol-3-angelate.
摘要翻译： 本发明一般涉及二萜杂环化合物的合成方法。 更具体地说，本发明涉及从式（1）的化合物合成烯内酯（式（21），CAS 30220-46-3））的有效方法。 本发明还提供了沿着联合烯醇的合成途径的各种有利的中间体。 在有关类似物的设计和合成中，如烯雌醇-3-天竺葵素，有效合成烯醇是重要的。
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5.发明授权ENVIRONMENTALLY-FRIENDLY NEW OXIDATION PROCESS FOR CONVERTING ARYL-1,2-DIOL TO KETONE 有权对于芳基-1,2-二醇的IN酮CONVERSION新型环保氧化法
公开(公告)号：EP2669264B1
公开(公告)日：2016-03-09
申请号：EP11857158.7
申请日：2011-12-29
发明人： Chen, Ting , Wang, Yu
CPC分类号： C07C45/30 , C07C45/294 , C07C2601/14 , C07C49/83 , C07C49/84 , C07C49/825 , C07C49/337 , C07C49/573
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6.发明公开ENVIRONMENTALLY-FRIENDLY NEW OXIDATION PROCESS FOR CONVERTING ARYL-1,2-DIOL TO KETONE 有权对于芳基-1,2-二醇的IN酮CONVERSION新型环保氧化法
公开(公告)号：EP2669264A1
公开(公告)日：2013-12-04
申请号：EP11857158.7
申请日：2011-12-29
发明人： Chen, Ting , Wang, Yu
CPC分类号： C07C45/30 , C07C45/294 , C07C2601/14 , C07C49/83 , C07C49/84 , C07C49/825 , C07C49/337 , C07C49/573
摘要： The present invention relates to the technical field of radiation curing photopolymerization initiator, and particularly to an environmentally-friendly new oxidation process for converting several specific aryl-1,2-diol compounds to corresponding arylhydroxyketones.
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公开(公告)号：EP2154123B1
公开(公告)日：2013-10-23
申请号：EP08764426.6
申请日：2008-05-14
发明人： NAKAZAWA, Koichi
IPC分类号： C07C47/575 , C07C45/30
CPC分类号： C07C45/30 , C07C47/575
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8.发明公开PREPARATION OF BICYCLO[2.2.2]OCTAN-2-ONE COMPOUNDS 有权HERSTELLUNG VON BICYCLO- [2,2,2] OCTAN-2-ON-VERBINDUNGEN
公开(公告)号：EP2630111A2
公开(公告)日：2013-08-28
申请号：EP11820867.7
申请日：2011-10-19
IPC分类号： C07C45/51 , C07C45/61 , C07C45/86 , C07C47/198 , C07C309/66 , C07D317/72
CPC分类号： C07C45/67 , C07C29/147 , C07C45/29 , C07C45/30 , C07C45/59 , C07C45/66 , C07C45/81 , C07C67/313 , C07C309/66 , C07C2601/14 , C07C2602/44 , C07D317/72 , C07C49/747 , C07C69/738 , C07C35/21 , C07C49/757 , C07C49/683
摘要： The present invention relates to a new process for the preparation of 6-hydroxy-5-arylbicyclo[2.2.2]octan-2-one compounds of the formula (II); which may subsequently be further transformed to compounds of the formula (I): The present invention further relates to novel compounds as such, which compounds are useful intermediates in the above process.
摘要翻译： 本发明涉及制备式（II）的6-羟基-5-芳基二环[2.2.2]辛-2-酮化合物的新方法; 其随后可以进一步转化为式（I）的化合物：本发明还涉及本发明的新化合物，该化合物在上述方法中是有用的中间体。
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公开(公告)号：EP2594550A1
公开(公告)日：2013-05-22
申请号：EP11806559.8
申请日：2011-05-30
申请人： Tohoku University
发明人： IWABUCHI Yoshiharu , HAYASHI Masaki
IPC分类号： C07C45/30 , B01J31/02 , C07C45/38 , C07C45/39 , C07C47/228 , C07C47/575 , C07C49/04 , C07C49/213 , C07C49/407 , C07C49/437 , C07C49/453 , C07C49/657 , C07C49/76 , C07C49/784 , C07C269/06 , C07C271/24 , C07D213/50 , C07H9/04 , C07H19/16 , C07B53/00 , C07B61/00
CPC分类号： C07H19/16 , B01J31/0235 , B01J2231/70 , C07B53/00 , C07B2200/07 , C07C45/29 , C07C45/30 , C07C45/39 , C07C201/12 , C07C269/06 , C07C2601/14 , C07C2603/74 , C07D213/50 , C07D493/20 , C07H9/04 , C07H19/167 , C07C271/24 , C07C205/44 , C07C47/228 , C07C49/213 , C07C49/407 , C07C49/437 , C07C49/76 , C07C49/04 , C07C49/657 , C07C49/453 , C07C47/235 , C07C47/575 , C07C49/784
摘要： A method for oxidizing an alcohol, wherein oxidation is performed in the presence of a compound represented by the following formula (I) and a bulk oxidant, which enables efficient oxidation of secondary alcohols as well as primary alcohols, and can attain high reaction efficiency even when air is used as a bulk oxidant.
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10.发明公开Retinoids useful in the treatment of cancer and for reducing serum triglycerides 有权类视黄醇在癌症治疗中的用途和用于降低血清甘油三酯水平
公开(公告)号：EP2292576A3
公开(公告)日：2013-01-23
申请号：EP10012438.7
申请日：2005-08-23
发明人： Brouillette, Wayne, J. , Muccio, Donald, D. , Atigadda, Venkatram, Reddy , Ruppert, John, M. , Lobo Ruppert, Susan, M.
IPC分类号： C07C29/14 , C07C45/29 , C07C45/30 , C07C45/51 , C07C45/61 , C07C45/67 , C07C45/68 , C07C47/238 , C07C49/403 , C07C49/417 , C07C49/603 , C07C49/683 , C07C49/753 , C07C51/06 , C07C57/50 , A61K31/203 , A61P35/00 , A61P3/06
CPC分类号： A61K31/202 , A61K9/0014 , A61K45/06 , C07B2200/09 , C07C29/14 , C07C45/29 , C07C45/292 , C07C45/30 , C07C45/513 , C07C45/61 , C07C45/673 , C07C45/68 , C07C47/238 , C07C49/403 , C07C49/417 , C07C49/603 , C07C49/683 , C07C49/713 , C07C49/753 , C07C51/09 , C07C57/26 , C07C57/50 , C07C67/343 , C07C403/08 , C07C403/14 , C07C403/20 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2602/10 , C07C2602/28 , C07D311/96 , C12C11/02 , C07C33/16 , C07C69/618
摘要： The present invention relates to a compound having the formula XXX
or
wherein R 1 is a C 5 or greater branched or straight chain alkyl group;
R 2 is hydrogen, a C 1 -C 15 branched or straight chain alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted cycloalkyl group, or R 1 and R 2 collectively form a substituted or unsubstituted fused aryl group; and
R 3 is one or more groups comprising, independently, hydrogen, a C 1 -C 15 branched or straight chain alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted cycloalkyl group;
R 6 and R 7 are, independently, hydrogen, a C 1 -C 15 branched or straight chain alkyl group, or a substituted or unsubstituted cycloalkyl group;
R 11 is hydrogen or a C 1 -C 15 branched or straight chain alkyl group; and n is from 0 to 3,
wherein one or more carbon atoms in the ring in formula XXX can optionally be replaced with a heteroatom, or the pharmaceutically-acceptable salt or ester thereof,
wherein the compound is not (2E,4E,6Z,8E)-8-(3',4'-dihydro-1'(2'H-naphthalen-1'-ylidene))-3,7-dimethyl-2,4,6-octatrienoic acid or an ester thereof; (2E,4E,6E,8E)-8-(3',4'-dihydro-1'(2'H-naphthalen-1'-ylidene))-3,7-dimethyl-2,4,6-octatrienoic acid or an ester thereof; (2E,4E,6Z,8E)-8-(3',4'-dihydro-4'methyl-1'(2'H-naphthalen-1'-ylidene))-3,7-dimethyl-2,4,6-octatrienoic acid or an ester thereof; and (2E,4E,6Z,8E)-8-(3',4'-dihydro-5',7'-dimethyl-1'(2'H-naphthalen-1'-ylidene))-3,7-dimethyl-2,4,6-octatrienoic acid or an ester thereof.
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