CERTAIN 5-ALKYL-2-ARYLAMINOPHENYLACETIC ACIDS AND DERIVATIVES
    4.
    发明公开
    CERTAIN 5-ALKYL-2-ARYLAMINOPHENYLACETIC ACIDS AND DERIVATIVES 有权
    某些5-烷基-2-氨基苯乙烯基乙酸和衍生物

    公开(公告)号:EP1007505A1

    公开(公告)日:2000-06-14

    申请号:EP98948872.1

    申请日:1998-08-26

    IPC分类号: C07C229/42

    CPC分类号: C07C229/42

    摘要: Disclosed are the compounds of formula (I), wherein R is methyl or ethyl; R1 is chloro or fluoro; R2 is hydrogen or fluoro; R3 is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy; R4 is hydrogen or fluoro; and R5 is chloro, fluoro, trifluoromethyl or methyl; pharmaceutically acceptable salts thereof; and pharmaceutically acceptable prodrug esters thereof; as selective COX-2 cyclooxygenase inhibitors.

    摘要翻译: 公开了式(I)的化合物,其中R是甲基或乙基; R1是氯或氟; R2是氢或氟; R3是氢,氟,氯,甲基,乙基,甲氧基,乙氧基或羟基; R4是氢或氟; 和R5是氯,氟,三氟甲基或甲基; 其药学上可接受的盐; 及其药学上可接受的前药酯; 作为选择性COX-2环加氧酶抑制剂。