摘要:
The invention concerns a method for separating from a mixture two optical isomers using a simulated mobile bed, consisting of an assembly of columns (C1,C2,C3,C4, C5,C6,C7,C8) divided into at least three successive zones (I, II, III). Said method is characterised in that the amount of charge injected is greater than that of the state of a predetermined reference state, and the discharge flow is greater than that of said predetermined reference state if it is required at least to preserve the purity of the less immobilised enantiomer, or the discharge flow is less than that of the reference state if it is required to preserve the purity of the more immobilised enantiomer.
摘要:
The invention concerns a method for multiple-column chromatographic separation producing at least two fractions, comprising the following steps: in output of the extract, zone I, or the raffinate zone, zone III: (i) drawing at least part of the output flow of said zone; (ii) concentrating said part; and (iii) re-injecting at least partly said concentrated part. The invention also concerns a device for implementing said method.
摘要:
The invention concerns a chromatographic device comprising: a column (12) for receiving a chromatographic bed (14) through which flows a first fluid; a piston (36) sliding inside the column (12) and exerting pressure on the bed (14), a chamber (28) containing a second fluid exerting pressure on the piston (36); a regulator (52) for the pressure exerted by the piston (36) on the bed based on the pressure inside the chamber (28), on the flow pressure of the first fluid at the intake of the column (12) and on a reference pressure on the bed (14). Said device enables to separate at least two compounds to be subjected to chromatographic analysis, while adjusting the pressure exerted on the chromatographic bed. The device efficiently uses the chromatographic bed while protecting it.
摘要:
The invention concerns a method for separating from a mixture two optical isomers using a simulated mobile bed, consisting of an assembly of columns (C1,C2,C3,C4, C5,C6,C7,C8) divided into at least three successive zones (I, II, III). Said method is characterised in that the amount of charge injected is greater than that of the state of a predetermined reference state, and the discharge flow is greater than that of said predetermined reference state if it is required at least to preserve the purity of the less immobilised enantiomer, or the discharge flow is less than that of the reference state if it is required to preserve the purity of the more immobilised enantiomer.
摘要:
The invention concerns a method for multiple-column chromatographic separation producing at least two fractions, comprising the following steps: in output of the extract, zone I, or the raffinate zone, zone III: (i) drawing at least part of the output flow of said zone; (ii) concentrating said part; and (iii) re-injecting at least partly said concentrated part. The invention also concerns a device for implementing said method.