公开(公告)号：EP0882131A1

公开(公告)日：1998-12-09

申请号：EP97905653.0

申请日：1997-02-07

申请人： NOVO NORDISK BIOTECH, INC. ,  NOVO NORDISK A/S

发明人： BERKA, Randy, M. ,  CHRISTGAU, Stephan ,  SHUSTER, Jeff ,  HALKIER, Torben ,  FUGLSANG, Claus, Crone

IPC分类号： C12N15 ,  C07K19 ,  C12N1 ,  C12N9 ,  C12R1

CPC分类号： C12Y302/01084 ,  C12N9/2402 ,  Y10S435/933 ,  Y10S435/935

摘要： The present invention relates to polypeptides having mutanase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to oral cavity compositions and methods for degrading mutan.

公开(公告)号：EP1011620A1

公开(公告)日：2000-06-28

申请号：EP97943796.9

申请日：1997-10-13

申请人： NOVO NORDISK A/S

发明人： FUGLSANG, Claus, Crone ,  TSUCHIYA, Rie

IPC分类号： A61K7/16 ,  C12N9/42

CPC分类号： C12Y302/01006 ,  A61K8/66 ,  A61Q11/00 ,  C12N9/244

摘要： The present invention relates to an oral care composition comprising a Cellulose Binding Domain and further ingredient conventionally used in oral care compositions, oral care products, and the user of CBDs for oral care purposes.

公开(公告)号：EP0954570A1

公开(公告)日：1999-11-10

申请号：EP97928131.0

申请日：1997-06-30

申请人： NOVO NORDISK A/S

发明人： WAHLEITHNER, Jill, Angela ,  FUGLSANG, Claus, Crone ,  HALKIER, Torben ,  JOHANSEN, Charlotte ,  HANSEN, Mogens, Trier

IPC分类号： A23K1 ,  A23L1 ,  A61K8 ,  A61Q11 ,  C12N1 ,  C12N9 ,  C12N15 ,  A61K38 ,  C12R1

CPC分类号： C12Y302/01084 ,  A23K20/189 ,  A23L29/06 ,  A61K8/66 ,  A61K38/00 ,  A61K2800/86 ,  A61Q11/00 ,  C07K2319/02 ,  C12N9/2402

摘要： The present invention relates to method for constructing an expression vector comprising a mutanase gene obtained from a filamentous fungus suitable for heterologous production comprising the steps of a) isolating a DNA sequence encoding a mutanase from a filamentous fungus, b) introducing a kex2-site or kex2-like site between the DNA sequences encoding the pro-peptide and the mature region of the mutanase, c) cloning the DNA sequence obtained in step b) into a suitable expression vector. The invention also relates to a recombinant expression vector comprising said mutanase gene sequence and a kex2 cleavage site between the DNA sequence encoding the pro-peptide and the region encoding the mature mutanase, a filamentous fungus host cell, a process for producing recombinant mutanase and a recombinant mutanase. It is also the object of the invention to provide compositions useful in oral care products for humans and animals.

公开(公告)号：EP0951272A1

公开(公告)日：1999-10-27

申请号：EP97944756.0

申请日：1997-10-27

申请人： NOVO NORDISK A/S

发明人： FUGLSANG, Claus, Crone

IPC分类号： A61K8 ,  A61K38 ,  A61Q11 ,  C07K19 ,  C12N9

CPC分类号： A61K8/64 ,  A61K8/66 ,  A61K38/00 ,  A61Q11/00 ,  C07K2319/00 ,  C12N9/20 ,  C12N9/2402 ,  C12Y302/01011 ,  C12Y302/01084

摘要： The present invention relates to a polypeptide hybrid comprising an amino acid sequence with binding affinity for mutan bound to an active component useful for oral care purposes, an oral care composition comprising a mutan binding domain, an oral care product comprising such an oral care composition of the invention, and finally the use of a mutan binding polypeptide hybrid or single unit MBD for oral care purposes, including preventing dental plaque formation and/or removal of existing dental plaque.

公开(公告)号：EP0910627A1

公开(公告)日：1999-04-28

申请号：EP97928132.0

申请日：1997-06-30

申请人： NOVO NORDISK A/S

发明人： CHRISTENSEN, Tove ,  FUGLSANG, Claus, Crone ,  HALKIER, Torben ,  JOHANSEN, Charlotte

IPC分类号： A23K1 ,  A23L1 ,  A61K8 ,  A61Q11 ,  C12N1 ,  C12N9 ,  C12N15 ,  C12R1

CPC分类号： C12N9/2454 ,  A61K8/66 ,  A61K2800/86 ,  A61Q11/00

摘要： The present invention relates to a cloned DNA sequence encoding an enzyme with dextranase activity, a recombinant expression vector comprising said DNA sequence, a filamentous fungus host cell, a method for producing said recombinant dextranase, and the isolated and purified enzyme. The invention also relates to compositions comprising the recombinant enzyme, oral care compositions and products and the use for removing of dental plaque.

公开(公告)号：EP1041890A1

公开(公告)日：2000-10-11

申请号：EP98962297.2

申请日：1998-12-22

申请人： NOVO NORDISK A/S

发明人： SCHNEIDER, Palle ,  CHRISTENSEN, Soren ,  DYBDAL, Lone ,  FUGLSANG, Claus, Crone ,  XU, Feng ,  GOLIGHTLY, Elizabeth

IPC分类号： A21D8/04 ,  C12N9/04

CPC分类号： C12N9/0006 ,  A21D8/042 ,  A61K38/00 ,  C07K14/705 ,  C07K14/79

摘要： The properties of dough or bread can be improved by the addition of a carbohydrate oxidase which can oxidise the reducing end of an oligosaccharide more efficiently than the corresponding monosaccharide, e.g., preferentially oxidizing maltodextrins or cellodextrins over glucose. A novel carbohydrate oxidase having the capability to oxidize maltodextrins and cellodextrins more efficiently than glucose may be obtained from a strain of Microdochium, particulary M. nivale. The amino acid sequence of the novel carbohydrate oxidase has very low homology (∫20 % identity) with known amino acid sequences.

公开(公告)号：EP0948606A1

公开(公告)日：1999-10-13

申请号：EP97949985.0

申请日：1997-12-10

申请人： NOVO NORDISK A/S

发明人： LASSEN, Soeren, Flensted ,  BECH, Lisbeth ,  FUGLSANG, Claus, Crone ,  BREINHOLT, Jens ,  OHMANN, Anders ,  STERGAARD, Peter, Rahbek

IPC分类号： A23K1 ,  A23L1 ,  C12N1 ,  C12N9 ,  C12N15 ,  C12P3 ,  C12R1

CPC分类号： C12Y301/03026 ,  A23K20/189 ,  A23L5/25 ,  A23L29/06 ,  C12N9/16 ,  C12P3/00

摘要： The present invention relates to an isolated polypeptide exhibiting phytase activity, the corresponding cloned DNA sequences, a process for preparing the polypeptide, and the use thereof for a number of industrial applications, in particular in animal feed. The novel phytase is derived from Peniophora lycii and has some interesting features, such as high initial affinity for the 6-position of phytic acid, a high initial rate of liberating phosphate from phytic acid and an exceptionally high specific activity.

公开(公告)号：EP1030561A1

公开(公告)日：2000-08-30

申请号：EP98951297.5

申请日：1998-11-04

申请人： NOVO NORDISK A/S

发明人： JOHANSEN, Charlotte ,  PEDERSEN, Anders, Hjelholt ,  FUGLSANG, Claus, Crone

IPC分类号： A01N63/04 ,  A01N37/10 ,  A01N35/04 ,  A61K7/00 ,  C11D3/386 ,  C11D3/48 ,  G02C13/00 ,  C09D5/14

摘要： A method for antimicrobial treatment of microorganisms and/or viruses comprising treating with an effective amount of a fungal Laccase and one or more enhancers in the presence of oxygen, O2, the enhancers being of formula (I).

公开(公告)号：EP0948606B1

公开(公告)日：2000-08-02

申请号：EP97949985.2

申请日：1997-12-10

申请人： NOVO NORDISK A/S

发明人： LASSEN, Soeren, Flensted ,  BECH, Lisbeth ,  FUGLSANG, Claus, Crone ,  BREINHOLT, Jens ,  OHMANN, Anders ,  STERGAARD, Peter, Rahbek

IPC分类号： C12N9/16

CPC分类号： C12Y301/03026 ,  A23K20/189 ,  A23L5/25 ,  A23L29/06 ,  C12N9/16 ,  C12P3/00

公开(公告)号：EP0958353A1

公开(公告)日：1999-11-24

申请号：EP97948748.0

申请日：1997-12-15

申请人： NOVO NORDISK A/S

发明人： LASSEN, Soeren Flensted ,  BECH, Lisbeth ,  OHMANN, Anders ,  BREINHOLT, Jens ,  FUGLSANG, Claus, Crone

IPC分类号： A23K1 ,  A23L1 ,  C12N1 ,  C12N9 ,  C12N15 ,  C12R1

CPC分类号： C12Y301/03026 ,  A23K20/189 ,  A23L5/25 ,  A23L29/06 ,  C12N9/16

摘要： The present invention relates to isolated polypeptides having phytase activity, the corresponding cloned DNA sequences, a process for preparing such polypeptides, and the use thereof for a number of industrial applications. In particular, the invention relates to phytases derived from the phyllum Basidiomycota, phytases of certain consensus sequences and fungal 6-phytases.