公开(公告)号：EP1226164A1

公开(公告)日：2002-07-31

申请号：EP00973832.9

申请日：2000-10-25

申请人： NPS PHARMACEUTICALS, INC.

发明人： KRAPCHO, Karen,NPS Pharmaceuticals, Inc. ,  STORMANN, Thomas,NPS Pharmaceuticals, Inc. ,  LEVINTHAL, Cynthia,NPS Pharmaceuticals, Inc. ,  HAMMERLAND, Lance,NPS Pharmaceuticals, Inc. ,  STORJOHANN, Laura

IPC分类号： C07K14/435 ,  C07K14/705 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/63 ,  G01N33/53

CPC分类号： C07K14/70571 ,  A61K38/00 ,  C07K2319/00 ,  G01N33/9406 ,  G01N2500/00

摘要： A novel human metabotropic glutamate receptor (mGluR) protein is identified, sequenced, and cloned. The receptor may be used to screen for compounds that modulate the activity of the mGluR. The recombinant mGluR as well as compounds that modulate mGluR activity may be used in the diagnosis and treatment of neurological disorders and diseases.