公开(公告)号：EP1809318B1

公开(公告)日：2013-06-12

申请号：EP05825013.5

申请日：2005-11-01

申请人： NPS Pharmaceuticals, Inc. ,  Nycomed GmbH

发明人： SANGUINETTI, Elizabeth, L. ,  MARRIOTT, Thomas, B. ,  LOPANSRI, Jennifer ,  BLOSCH, Consuelo, Maria

IPC分类号： A61P1/00 ,  A61K38/26 ,  C07K14/605

CPC分类号： A61K38/26 ,  A61B5/4222 ,  A61K9/0019

摘要： Intestinal absorption is enhanced in short bowel syndrome patients presenting with colon-in-continuity by treatment with a GLP-2 receptor agonist, such as teduglutide.

公开(公告)号：EP1225888A2

公开(公告)日：2002-07-31

申请号：EP00982701.5

申请日：2000-10-19

申请人： NPS PHARMACEUTICALS, INC.

发明人： WELLS, David, S. ,  MARRIOTT, Thomas, B. ,  RAJEWSKI, Lian, G. ,  PIPKIN, James, D. ,  HASLAM, John, L.

IPC分类号： A61K31/195 ,  A61K31/16 ,  A61K31/19 ,  A61K31/60 ,  A61K31/22 ,  A61K31/165 ,  A61K31/18 ,  A61K31/255 ,  A61K31/27 ,  A61K9/28 ,  A61K9/50

CPC分类号： A61K31/27 ,  A61K9/205 ,  A61K9/2866 ,  A61K9/5042 ,  A61K31/16 ,  A61K31/18 ,  A61K31/19 ,  A61K31/255

摘要： Sustained-release compositions for delivering therapeutic concentrations of isovaleramide, isovaleric acid, and certain structurally related compounds are provided for the treatment for a variety of pathological conditions, including epilepsy and spasticity, which are ameliorated by effecting a modulation of CNS activity. The ability of the compositions to sustain relatively constant levels of the drug at a therapeutic dose in the serum for extended periods of time enables a once or twice daily administration schedule.