公开(公告)号：EP1179189A2

公开(公告)日：2002-02-13

申请号：EP00929722.7

申请日：2000-05-17

申请人： NYCOMED IMAGING AS

发明人： AXELSSON, Oskar,Nycomed Innovation AB ,  OLOFSSON, Charlotte,Nycomed Innovation AB ,  MORGENSTJERNE, Axel ,  HANSSON, Georg,Nycomed Innovation AB ,  JOHANNESSON, Haukur,Nycomed Innovation AB ,  ARDENKJAER-LARSEN, Jan H.,Nycomed Innovation AB

IPC分类号： G01R33/28 ,  C07C69/675 ,  C07C67/303 ,  A61K49/00

CPC分类号： A61K49/1815

摘要： The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.