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公开(公告)号：EP2170378A2
公开(公告)日：2010-04-07
申请号：EP06844086.6
申请日：2006-04-06
IPC分类号： A61K39/085
CPC分类号： C07K16/1271 , A61K39/085 , A61K2039/505 , A61K2039/6068
摘要： A method of preventing or treating staphylococcal bacterial infection in an individual is disclosed. A vaccine based on a conjugate the 336 polysaccharide antigen can be used for active protection in individuals who are to be subjected to conditions that place them at immediate risk of developing a bacterial infection, as would be case in the context of a catheterization or a surgical procedure. Alternatively, antibodies raised in response to the antigen can be used to treat or to provide passive protection to individuals. The method can be used in a population of patients at risk for infection by various species of Staphylococcus or various types of Staphylococcus aureus.
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公开(公告)号：EP2320898A2
公开(公告)日：2011-05-18
申请号：EP09763454.7
申请日：2009-06-09
发明人： KALNIK, Matthew , HOHENBOKEN, Matthew , KESSLER, Paul , FATTOM, Ali , FAHIM, Raafat , HUDSON, Leslie
IPC分类号： A61K31/465 , G01N33/535 , A61P25/34
CPC分类号： A61K31/465 , G01N33/6854 , G01N33/944
摘要： Described are smoking cessation devices and kits for determining an advantageous time for a subject to quit smoking, and/or for extending the duration of smoking abstinence, based on serum levels of anti-nicotine antibodies. Related methods are also described.
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公开(公告)号：EP2459215A1
公开(公告)日：2012-06-06
申请号：EP10742944.1
申请日：2010-07-29
发明人： FAHIM, Raafat , FATTOM, Ali , KESSLER, Paul , KALNIK, Matthew
IPC分类号： A61K39/00 , A61K31/137 , A61K31/498 , A61P25/34 , A61K39/395 , C07K16/44 , A61K31/465
CPC分类号： C07K16/44 , A61K31/137 , A61K31/4985 , A61K39/0013 , A61K39/39583 , A61K45/06 , A61K2039/505 , A61K2300/00
摘要： Described are methods and kits related to treating nicotine addiction and increasing the likelihood of nicotine abstinence. Methods and kits for reestablishing nicotine abstinence after a relapse to nicotine use are also described. The methods and kits comprise a combination of (a) one or more of a nicotine immunogenic composition and / or an anti-nicotine antibody- composition and (b) one or more compounds selected from the group consisting of a second nicotine immunogenic composition, a second anti-nicotine antibody, a nicotine receptor agonist and a nicotine receptor antagonist.
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公开(公告)号：EP2046377A1
公开(公告)日：2009-04-15
申请号：EP07874414.1
申请日：2007-07-20
IPC分类号： A61K39/00 , A61K39/385 , C12N5/06
CPC分类号： A61K39/085 , A61K2039/505 , A61K2039/6037 , C07K16/1271
摘要： A method of preventing or treating staphylococcal bacterial infection in an individual is disclosed. A vaccine based on a conjugate of PS1 polysaccharide antigen can be used for active protection in individuals who are to be subjected to conditions that place them at immediate risk of developing a bacterial infection, as would be case in the context of a catheterization or a surgical procedure. Alternatively, antibodies raised in response to the antigen can be used to treat or to provide passive protection to individuals. The method can be used in a population of patients at risk for infection by various species of Staphylococcus or various types of Staphylococcus epidermidis.
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公开(公告)号：EP1846025A2
公开(公告)日：2007-10-24
申请号：EP05852731.8
申请日：2005-12-02
发明人： FATTOM, Ali , HAUSKNECHT, Ed , WINSTON, Scott , FULLER, Steve
IPC分类号： A61K39/085 , A61K39/39
CPC分类号： A61K39/39 , A61K39/085 , A61K2039/55511 , A61K2039/5555 , A61K2039/60
摘要： The present invention relates to vaccines for treating bacterial infections, which vaccines comprise a glycoconjugate immunogen comprising at least one capsular polysaccharide conjugated to a carrier protein, such that the capsular polysaccharide contains an amount of peptidoglycan effective to improve the vaccine's properties.
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