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公开(公告)号：EP2170378A2
公开(公告)日：2010-04-07
申请号：EP06844086.6
申请日：2006-04-06
IPC分类号： A61K39/085
CPC分类号： C07K16/1271 , A61K39/085 , A61K2039/505 , A61K2039/6068
摘要： A method of preventing or treating staphylococcal bacterial infection in an individual is disclosed. A vaccine based on a conjugate the 336 polysaccharide antigen can be used for active protection in individuals who are to be subjected to conditions that place them at immediate risk of developing a bacterial infection, as would be case in the context of a catheterization or a surgical procedure. Alternatively, antibodies raised in response to the antigen can be used to treat or to provide passive protection to individuals. The method can be used in a population of patients at risk for infection by various species of Staphylococcus or various types of Staphylococcus aureus.
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公开(公告)号：EP2046377A1
公开(公告)日：2009-04-15
申请号：EP07874414.1
申请日：2007-07-20
IPC分类号： A61K39/00 , A61K39/385 , C12N5/06
CPC分类号： A61K39/085 , A61K2039/505 , A61K2039/6037 , C07K16/1271
摘要： A method of preventing or treating staphylococcal bacterial infection in an individual is disclosed. A vaccine based on a conjugate of PS1 polysaccharide antigen can be used for active protection in individuals who are to be subjected to conditions that place them at immediate risk of developing a bacterial infection, as would be case in the context of a catheterization or a surgical procedure. Alternatively, antibodies raised in response to the antigen can be used to treat or to provide passive protection to individuals. The method can be used in a population of patients at risk for infection by various species of Staphylococcus or various types of Staphylococcus epidermidis.
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3.发明授权
公开(公告)号：EP1135166B1
公开(公告)日：2004-10-13
申请号：EP99964009.7
申请日：1999-12-01
IPC分类号： A61K47/48 , A61K39/385
CPC分类号： A61K39/0013 , A61K47/646 , A61K47/6803 , A61K2039/505 , A61K2039/6037 , A61K2039/6068 , C07K16/44 , Y10S435/975 , Y10S436/816 , Y10S530/807
摘要： Novel hapten-carrier conjugates are capable of inducing the production of antibodies, in vivo, that specifically bind to nicotine. These conjugates comprise a nicotine hapten conjugated to an immunogenic carrier protein. The novel conjugates preserve the chirality of nicotine in its native (S)-(-) state, and have good stability properties. The conjugates are useful in formulating vaccines for active immunization, that are used to prevent and treat nicotine addiction. The antibodies raised in response to the nicotine hapten-carrier conjugate are used for passive immunization. These antibodies are administered for prevention and treatment of nicotine addiction.
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公开(公告)号：EP1963308A2
公开(公告)日：2008-09-03
申请号：EP06837711.8
申请日：2006-11-15
发明人： ENNIFAR, Sofiane
IPC分类号： C07D403/04
CPC分类号： C07D401/04
摘要： A high yielding and short process for preparing the 3'-aminomethylnicotine hapten of general formula (I) permits the isolation of the hapten in very pure quantities. The process can be adapted for the synthesis of a single stereoisomer or mixtures of stereoisomers, such as the stereoisomers trans-Ia and trans-Ib. Compounds of general formula (I) are useful for the preparation of hapten-carrier conjugates in the treatment of nicotine addiction.
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5.发明授权
公开(公告)号：EP1135166B9
公开(公告)日：2005-02-02
申请号：EP99964009.7
申请日：1999-12-01
IPC分类号： A61K47/48 , A61K39/385
CPC分类号： A61K39/0013 , A61K47/646 , A61K47/6803 , A61K2039/505 , A61K2039/6037 , A61K2039/6068 , C07K16/44 , Y10S435/975 , Y10S436/816 , Y10S530/807
摘要： Novel hapten-carrier conjugates are capable of inducing the production of antibodies, in vivo, that specifically bind to nicotine. These conjugates comprise a nicotine hapten conjugated to an immunogenic carrier protein. The novel conjugates preserve the chirality of nicotine in its native (S)-(-) state, and have good stability properties. The conjugates are useful in formulating vaccines for active immunization, that are used to prevent and treat nicotine addiction. The antibodies raised in response to the nicotine hapten-carrier conjugate are used for passive immunization. These antibodies are administered for prevention and treatment of nicotine addiction.
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