专利检索 ap:("Natera, Inc.") AND inv:"SERGEEV, Nikolay" 第 1 页

1.

发明公开
COMPOSITIONS AND METHODS FOR DETECTION OF NUCLEIC ACID MUTATIONS 审中-公开

公开(公告)号：EP3510171A1

公开(公告)日：2019-07-17

申请号：EP17821368.2

申请日：2017-06-30

申请人： Natera, Inc.

发明人： ZIMMERMANN, Bernhard , BABIARZ, Joshua , SALARI, Raheleh , CONSTANTIN, Tudor Pompiliu , SAKARYA, Onur , PROSEN, Dennis , OLSON, Alexander , DASHNER, Scott , SERGEEV, Nikolay , HILL, Matthew Micah

IPC分类号： C12Q1/68 , G06F19/18

2.

发明公开
COMPOSITIONS AND METHODS FOR DETECTION OF NUCLEIC ACID MUTATIONS 审中-公开

公开(公告)号：EP3792365A1

公开(公告)日：2021-03-17

申请号：EP20203880.8

申请日：2017-06-30

申请人： Natera, Inc.

发明人： ZIMMERMAN, Bernhard , BABIARZ, Joshua , SALARI, Raheleh , CONSTANTIN, Tudor Pompiliu , SAKARYA, Onur , PROSEN, Dennis , DASHMER, Scott , SERGEEV, Nikolay , HILL, Matthew Micah

IPC分类号： C12Q1/68 , C12Q1/6827

摘要： The invention provides methods and compositions for detecting a mutation in a target gene in a sample or a fraction thereof, including in certain examples, a fraction that includes circulating tumor DNA. The methods can include a tiling PCR reaction, for example a one-sided multiplex tiling reaction. Virtually any type of mutation can be detected with the methods and compositions. In certain embodiments, gene fusions are detected. Improved PCR methods, especially for performing nested multiplex PCR reactions are provided.