公开(公告)号：EP1657248A2

公开(公告)日：2006-05-17

申请号：EP05017940.7

申请日：2005-08-18

申请人： National Chung-Hsing University

发明人： Chien, Maw-Sheng ,  Liu, Cheng-I ,  Liao, Chih-Ming

IPC分类号： C07K14/285 ,  A61K39/102 ,  C12N15/09

CPC分类号： A61K39/102 ,  C07K14/285

摘要： The present invention relates to an animal vaccine directed to progressive atrophic rhinitis (PAR), comprising at least two fragmens of recombinant subunit Pasteurella multocida toxins (rsPMT) capable of eliciting the production of antibodies against Pasteurella multocida associated with PAR, said fragments each having an amino acid sequence that substantially corresponds to the 2-486, 486-986 or 986-1281 amino acid residues of Pasteurella multocida toxin (PMT), respectively. Also disclosed is a multivalent animal vaccine, comprising said fragments as active components against PAR, and at least a pathogenic antigen or epitope thereof associated with other animal disease(s), such as inactivated gE-deleted Pseudorabies virus.

摘要翻译： 本发明涉及针对渐进萎缩性鼻炎（PAR）的动物疫苗，其包含能够引发生产具有PAR关联的针对多杀性巴氏杆菌抗体的重组亚单位多杀性巴氏杆菌毒素的至少两个问题男子（rsPMT），所述片段各具有在 氨基酸序列没有基本上分别对应于多杀性巴氏杆菌毒素的2-486，486-986或986-1281个氨基酸残基（PMT）。 游离缺失所以盘是多价疫苗的动物，包括所述片段针对PAR作为活性组分，以及至少一个致病抗原或其表位与其它动物疾病（一个或多个）相关联：如灭活GE-删除伪狂犬病病毒。

公开(公告)号：EP1657248B1

公开(公告)日：2011-10-26

申请号：EP05017940.7

申请日：2005-08-18

申请人： National Chung-Hsing University

发明人： Chien, Maw-Sheng ,  Liu, Cheng-I ,  Liao, Chih-Ming

IPC分类号： C07K14/285 ,  A61K39/102 ,  C12N15/09

CPC分类号： A61K39/102 ,  C07K14/285

公开(公告)号：EP1657248A3

公开(公告)日：2006-05-24

申请号：EP05017940.7

申请日：2005-08-18

申请人： National Chung-Hsing University

发明人： Chien, Maw-Sheng ,  Liu, Cheng-I ,  Liao, Chih-Ming

IPC分类号： C07K14/285 ,  A61K39/102 ,  C12N15/09

CPC分类号： A61K39/102 ,  C07K14/285

摘要： The present invention relates to an animal vaccine directed to progressive atrophic rhinitis (PAR), comprising at least two fragmens of recombinant subunit Pasteurella multocida toxins (rsPMT) capable of eliciting the production of antibodies against Pasteurella multocida associated with PAR, said fragments each having an amino acid sequence that substantially corresponds to the 2-486, 486-986 or 986-1281 amino acid residues of Pasteurella multocida toxin (PMT), respectively. Also disclosed is a multivalent animal vaccine, comprising said fragments as active components against PAR, and at least a pathogenic antigen or epitope thereof associated with other animal disease(s), such as inactivated gE-deleted Pseudorabies virus.

摘要翻译： 本发明涉及针对进行性萎缩性鼻炎（PAR）的动物疫苗，其包含至少两个重组亚单位出血败血性巴斯德氏菌毒素（rsPMT）片段，其能够引发产生针对与PAR相关的多杀巴斯德氏菌的抗体，所述片段各自具有 氨基酸序列分别基本上对应于多杀巴斯德氏菌毒素（PMT）的2-486,486-986或986-1281个氨基酸残基。 还公开了多价动物疫苗，其包含所述片段作为针对PAR的活性成分，以及至少与其他动物疾病（例如失活的gE缺失的伪狂犬病病毒）相关的致病性抗原或其表位。