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1.发明公开COMPOSITION, KIT AND METHOD FOR DETECTING NEUROPATHY 审中-公开ZUSAMMENSETZUNG，KIT UND VERFAHRENFÜRDEN NACHWEIS VON NEUROPATHIEN
公开(公告)号：EP2267448A1
公开(公告)日：2010-12-29
申请号：EP09729095.1
申请日：2009-03-31
CPC分类号： G01N33/6893 , G01N2800/16 , G01N2800/168 , G01N2800/60
摘要： The present invention relates to a method for detecting a disease accompanied with neuropathy such as glaucoma, comprising measuring and/or detecting one or more of polypeptides shown in SEQ ID NOS: 1 to 15, mutants thereof, or fragments thereof in a biological sample from a subject, and also to a composition or kit for diagnosis of a disease accompanied with neuropathy such as glaucoma.
摘要翻译： 本发明涉及一种用于检测伴有神经病如青光眼的疾病的方法，包括测量和/或检测生物样品中SEQ ID NO：1至15所示多肽，其突变体或其片段中的一种或多种 受试者，以及用于诊断伴有神经病如青光眼的疾病的组合物或试剂盒。
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2.发明公开COMPOSITION, KIT AND METHOD FOR DETECTING AGING AND DISEASE ASSOCIATED WITH VASCULAR DISORDER 审中-公开组合物，药盒和方法检测衰老和疾病的均与血管疾病CONNECTION
公开(公告)号：EP2267447A1
公开(公告)日：2010-12-29
申请号：EP09728954.0
申请日：2009-03-31
CPC分类号： G01N33/6893 , G01N2800/00 , G01N2800/16 , G01N2800/32
摘要： The present invention relates to a method for detecting an ageing or a disease accompanied with a vascular disorder such as age-related macular degeneration, comprising measuring one or more of polypeptides comprising any of amino acid sequences shown in SEQ ID NOS: 1 to 21, mutants thereof, or fragments thereof in a biological sample from a subject, and also to a composition or kit for diagnosing an ageing or a disease accompanied with a vascular disorder such as age-related macular degeneration.
摘要翻译： 本发明涉及一种用于老化或有血管障碍相伴的疾病的检测：例如年龄相关性黄斑变性，包括测量一个或多个多肽，其包含在SEQ ID NOS中所示的任何氨基酸序列组成：1〜21， 其变异体，或来自受试者的生物样品中它们的片段，以及因此的组合物或试剂盒用于老化或有血管障碍相伴的疾病的诊断：如年龄相关的黄斑变性。
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公开(公告)号：EP1130018B1
公开(公告)日：2007-01-17
申请号：EP99954381.2
申请日：1999-11-04
发明人： SUZUKI, Tsutomu , MITA, Shiro , MATSUNO, Kiyoshi
IPC分类号： C07D295/08 , A61K31/495
CPC分类号： C07D295/096 , Y10S514/81 , Y10S514/811 , Y10S514/812 , Y10S514/813
摘要： Preventive or therapeutic agents for drug dependence, containing as the active ingredient 1,4-(diphenylalkyl)piperazine derivatives represented by general formula [I] or salts thereof, particularly preferably the one represented by general formula [II] or salts thereof, wherein R1 is lower alkoxy; R2 is lower alkoxy; A is lower alkylene; and B is lower alkylene.
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公开(公告)号：EP1130018A1
公开(公告)日：2001-09-05
申请号：EP99954381.2
申请日：1999-11-04
发明人： SUZUKI, Tsutomu , MITA, Shiro , MATSUNO, Kiyoshi
IPC分类号： C07D295/08 , A61K31/495
CPC分类号： C07D295/096 , Y10S514/81 , Y10S514/811 , Y10S514/812 , Y10S514/813
摘要： An object of the present invention is to find novel uses of 1, 4-(diphenylalkyl)piperazine derivatives. The present invention provides preventive or therapeutic agents for drug dependence comprising the 1, 4-(diphenylalkyl)piperazine derivatives represented by the following general formula [I] or salts thereof as active ingredients. Particularly preferred compounds or salts thereof are represented by the following formula [II] wherein R 1 is lower alkoxy; R 2 is lower alkoxy; "A" is lower alkylene; and "B" is lower alkylene.
摘要翻译： 本发明的目的是找到1,4-（二苯基烷基）哌嗪衍生物的新用途。 本发明提供用于药物依赖性的预防或治疗剂，其包含由以下通式表示的1,4-（二苯基烷基）哌嗪衍生物或其盐作为活性成分。 特别优选的化合物或其盐由下式表示：其中R 1是低级烷氧基; R 2是低级烷氧基; “A”是低级亚烷基; “B”为低级亚烷基。
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公开(公告)号：EP0711763B1
公开(公告)日：2000-10-18
申请号：EP94921809.3
申请日：1994-07-25
IPC分类号： C07D295/096 , A61K31/495
CPC分类号： C07D295/096
摘要： A novel compound represented by general formula [I], wherein R?1 and R2¿ may be the same or different from each other and each represents lower alkoxy; and A and B may be the same or different from each other and each represents lower alkylene. It has a σ receptor affinity and is useful as a remedy for diseases accompanying cranial nerve function disorder, such as dementia, depression, schizophrenia and anxiety, immunopathy and cryptorrhea, and digestive ulcer.
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公开(公告)号：EP0711763A1
公开(公告)日：1996-05-15
申请号：EP94921809.3
申请日：1994-07-25
IPC分类号： C07D295/096 , A61K31/495
CPC分类号： C07D295/096
摘要： A novel compound represented by general formula [I], wherein R¹ and R² may be the same or different from each other and each represents lower alkoxy; and A and B may be the same or different from each other and each represents lower alkylene. It has a σ receptor affinity and is useful as a remedy for diseases accompanying cranial nerve function disorder, such as dementia, depression, schizophrenia and anxiety, immunopathy and cryptorrhea, and digestive ulcer.
摘要翻译： 由通式ÄIÜ表示的新化合物，其中R 1和R 2可以彼此相同或不同，并且各自表示低级烷氧基; 并且A和B可以相同或不同，并且各自表示低级亚烷基。 它具有σ受体亲和力，可用作伴随颅神经功能障碍的疾病如痴呆，抑郁症，精神分裂症和焦虑症，免疫病和闭经和消化性溃疡。
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