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公开(公告)号：EP2138158B1
公开(公告)日：2015-09-30
申请号：EP08720753.6
申请日：2008-02-19
发明人： Imamura, Toru , Kimura, Miho , Kawano, Mitsuko , Tsujino, Nozomi , Kuramochi, Akiko , Oda, Yuko , Motomura, Kaori , Suzuki, Masashi , Asada, Masahiro , Kameyama, Azusa , Togayachi, Sumie , Oka, Syuichi
CPC分类号： C07K14/43536 , A61K8/64 , A61Q7/02 , G01N33/566 , G01N2333/50 , G01N2500/10
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公开(公告)号：EP2138158A1
公开(公告)日：2009-12-30
申请号：EP08720753.6
申请日：2008-02-19
发明人： Imamura, Toru , Kimura, Miho , Kawano, Mitsuko , Tsujino, Nozomi , Kuramochi, Akiko , Oda, Yuko , Motomura, Kaori , Suzuki, Masashi , Asada, Masahiro , Kameyama, Azusa , Togayachi, Sumie , Oka, Syuichi
CPC分类号： C07K14/43536 , A61K8/64 , A61Q7/02 , G01N33/566 , G01N2333/50 , G01N2500/10
摘要： A hair removing agent or a hair growth inhibiting agent is provided by determining an endogenous factor having a hair growth inhibitory activity, screening for substances having an activity similar to that of the endogenous factor or substances enhancing the activity or expression of the endogenous factor, and utilizing the physiological activities of such substances. It has been found that FGF18 inhibits hair growth. A method of screening for FGF18-like active substances, substances that promote the activity of FGF18 or substances that promote the expression of FGF18 to thereby obtain candidates for the hair growth inhibiting agent or hair removing agent is disclosed. Also disclosed is a hair growth inhibiting agent or a hair removing agent comprising, as an active ingredient, FGF18 and/or an FGF18 partial peptide, or an FGF18-like active substance and/or a substance that promotes the activity or expression of FGF18 (e.g., Digenea simplex extract).
摘要翻译： 通过测定具有毛发生长抑制活性的内源性因子，筛选具有与内源性因子相似的活性的物质或增强内源性因子的活性或表达的物质来提供脱毛剂或毛发生长抑制剂，以及 利用这些物质的生理活性。 已经发现FGF18抑制毛发生长。 公开了筛选FGF18样活性物质的方法，促进FGF18活性的物质或促进FGF18表达的物质，从而获得毛发生长抑制剂或脱毛剂的候选物。 还公开了一种毛发生长抑制剂或脱毛剂，其包含作为活性成分的FGF18和/或FGF18部分肽或FGF18样活性物质和/或促进FGF18活性或表达的物质（ 例如，Digenea单克隆提取物）。
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