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1.发明公开ALPHA2-MACROGLOBULIN FROM CEREBROSPINAL FLUID AS AN INDEX MARKER FOR NEUROMYELITIS OPTICA 审中-公开法富集分离RÜCKENMARKSFLÜSSIGKEITSGLYKOPROTEIN的，方法用于搜索标志物使用方法为中央神经系统疾病和标记为中央神经系统疾病
公开(公告)号：EP3101426A3
公开(公告)日：2017-02-08
申请号：EP16173307.6
申请日：2011-12-16
发明人： NARIMATSU, Hisashi , HIRABAYASHI, Jun , KUNO, Atsushi , MATSUZAKI, Hideki , IKEHARA, Yuzuru , ITO, Hiromi , HASHIMOTO, Yasuhiro , SHIROTANI, Keiro , FUTAKAWA, Satoshi , ARAI, Hajime , MIYAJIMA, Masakazu , FUJIHARA, Kazuo
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N33/6842 , G01N2333/47 , G01N2333/4728 , G01N2400/40 , G01N2800/285 , H01J49/0036
摘要： The purpose of the present invention is to develop: a method for selectively separating a glycoprotein derived from the central nervous system from a body fluid or a central nervous system cell; and a method for searching for an index marker for central nervous system diseases, which utilizes the aforementioned method. A protein derived from the central nervous system, which occurs in a trace amount in a body fluid or a central nervous system cell, can be selectively enriched by a two-stage separation procedure comprising removing a glycoprotein having sialic acid at a non-reducing terminal thereof from the body fluid or the central nervous system cell and then separating a glycoprotein having N-acetylglucosamine at a non-reducing terminal thereof.
摘要翻译： 本发明的目的是开发：一种方法，用于选择性地分离从体液或中枢神经系统细胞中枢神经系统衍生的糖蛋白; 并在indexmarker用于中枢神经系统疾病，其利用上述方法搜索的方法。 从中枢神经系统衍生的蛋白质，其在体液或中枢神经系统细胞的微量的发生时，可以通过两阶段分离过程包括去除在非还原末端具有唾液酸的糖蛋白选择性地富集 其从体液或中枢神经系统细胞，然后分离具有在其非还原末端的N-乙酰葡糖胺的糖蛋白。
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公开(公告)号：EP2884276A1
公开(公告)日：2015-06-17
申请号：EP13827110.1
申请日：2013-08-09
发明人： NARIMATSU, Hisashi , KUNO, Atsushi , IKEHARA, Yuzuru , HASHIMOTO, Yasuhiro , SHIROTANI, Keiro , NARA, Kiyomitsu , KARIYA, Yoshinobu , ITO, Hiromi , HOSHI, Kyoka
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N33/536 , G01N33/6854 , G01N2333/42 , G01N2333/4724 , G01N2400/00 , G01N2440/38 , G01N2496/00
摘要： It is intended to develop and provide a method for detecting a particular glycan-isoform rapidly and specifically by a small number of steps. The present invention provides a glycan-isoform detection method comprising quantifying an immune complex formed by the mixing of a test sample with a sugar chain non-reducing terminal residue-binding lectin and an antibody specifically binding to the protein moiety of the glycan-isoform, etc., comparing the obtained amount of the immune complex with the amount of a control immune complex obtained when a control sample is not mixed with the sugar chain non-reducing terminal residue-binding lectin or is mixed with a control protein, and determining the presence or absence of the glycan-isoform of interest in the test sample on the basis of the difference between these amounts.
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3.发明授权
公开(公告)号：EP3101426B1
公开(公告)日：2019-05-15
申请号：EP16173307.6
申请日：2011-12-16
发明人： NARIMATSU, Hisashi , HIRABAYASHI, Jun , KUNO, Atsushi , MATSUZAKI, Hideki , IKEHARA, Yuzuru , ITO, Hiromi , HASHIMOTO, Yasuhiro , SHIROTANI, Keiro , FUTAKAWA, Satoshi , ARAI, Hajime , MIYAJIMA, Masakazu , FUJIHARA, Kazuo
IPC分类号： G01N33/68
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4.发明公开ALPHA2-MACROGLOBULIN FROM CEREBROSPINAL FLUID AS AN INDEX MARKER FOR NEUROMYELITIS OPTICA 审中-公开法富集分离RÜCKENMARKSFLÜSSIGKEITSGLYKOPROTEIN的，方法用于搜索标志物使用方法为中央神经系统疾病和标记为中央神经系统疾病
公开(公告)号：EP3101426A2
公开(公告)日：2016-12-07
申请号：EP16173307.6
申请日：2011-12-16
发明人： NARIMATSU, Hisashi , HIRABAYASHI, Jun , KUNO, Atsushi , MATSUZAKI, Hideki , IKEHARA, Yuzuru , ITO, Hiromi , HASHIMOTO, Yasuhiro , SHIROTANI, Keiro , FUTAKAWA, Satoshi , ARAI, Hajime , MIYAJIMA, Masakazu , FUJIHARA, Kazuo
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N33/6842 , G01N2333/47 , G01N2333/4728 , G01N2400/40 , G01N2800/285 , H01J49/0036
摘要： The purpose of the present invention is to develop: a method for selectively separating a glycoprotein derived from the central nervous system from a body fluid or a central nervous system cell; and a method for searching for an index marker for central nervous system diseases, which utilizes the aforementioned method. A protein derived from the central nervous system, which occurs in a trace amount in a body fluid or a central nervous system cell, can be selectively enriched by a two-stage separation procedure comprising removing a glycoprotein having sialic acid at a non-reducing terminal thereof from the body fluid or the central nervous system cell and then separating a glycoprotein having N-acetylglucosamine at a non-reducing terminal thereof.
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