公开(公告)号：EP4425183A1

公开(公告)日：2024-09-04

申请号：EP22887189.3

申请日：2022-10-28

申请人： National University Corporation Hamamatsu University School of Medicine

发明人： SUZUKI Yuko ,  URANO Tetsumei

IPC分类号： G01N33/86 ,  C12Q1/37 ,  G01N33/48

CPC分类号： C12Q1/37 ,  G01N33/86 ,  G01N33/48

摘要： An object of the present invention is to provide a method for easily evaluating residual fibrinolytic resistance activity by PAI-1 and α2AP in blood plasma. The present invention is a method of evaluating fibrinolytic resistance activity, the method including a pretreatment step of adding an anionic surfactant to some of a blood plasma sample derived from a test animal and incubating the blood plasma for a predetermined time, a first fibrinolytic resistance measurement step of measuring an index value of fibrinolytic resistance activity in treated blood plasma obtained by the pretreatment step, a second fibrinolytic resistance measurement step of measuring an index value of fibrinolytic resistance activity in some of the blood plasma sample derived from the test animal, and an evaluation step of evaluating the fibrinolytic resistance activity by PAI-1 and α2AP in the blood plasma of the test animal, based on the index value measured in the first fibrinolytic resistance measurement step and the index value of untreated blood plasma measured in the second fibrinolytic resistance measurement step.