公开(公告)号：EP1757296A1

公开(公告)日：2007-02-28

申请号：EP05743550.5

申请日：2005-05-26

申请人： National University Corporation Kagawa University

发明人： TOKUDA, M., Faculty of Medicine, Kagawa University ,  TSUKAMOTO, I., Faculty of Medicine, Kagawa Univ. ,  KONISHI, R., Faculty of Medicine, Kagawa Univ. ,  KUBOTA, Y., Faculty of Medicine, Kagawa University ,  IZUMORI, Ken, Rare Sugar Research Center

IPC分类号： A61K31/7004 ,  A23K1/16 ,  A23L1/30 ,  A61P19/02 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07H3/02 ,  C07H3/08

CPC分类号： C07H3/08 ,  A23L33/10 ,  A61K31/7004 ,  C07H3/02

摘要： [PROBLEMS] To find out a specific rare sugar having effects of inhibiting the proliferation of vascular endothelial cells and lumen formation and utilize these effects. To provide this rare sugar as a preventive/remedy for diseases with angiogenesis, a cosmetic or a functional food. [MEANS FOR SOLVING PROBLEMS] A method of controlling the proliferation of vascular endothelial cells characterized by utilizing the vascular endothelial cell proliferation-controlling effect of D-mannose, D-allose, 2-deoxy-D-glucose, 3-deoxy-D-glucose, L-sorbose, 2-deoxy-D-ribose and/or 2-deoxy-L-ribose. A method of inhibiting lumen formation of vascular endothelial cells characterized by utilizing the vascular endothelial cell lumen formation-inhibiting effect of D-allose, D-altrose, D-gulose, D-talose, L-allose, 2-deoxy-D-glucose, 3-deoxy-D-glucose, D-ribose, L-ribose, 2-deoxy-D-ribose and/or 2-deoxy-L-ribose.

摘要翻译： [问题]找出具有抑制血管内皮细胞增殖和管腔形成的作用的特定稀有糖并利用这些效果。 提供这种罕见的糖作为血管生成疾病，化妆品或功能性食物的预防/补救。 [解决问题的手段]控制血管内皮细胞增殖的方法，其特征在于利用D-甘露糖，D-阿洛糖，2-脱氧-D-葡萄糖，3-脱氧-D-葡萄糖的血管内皮细胞增殖抑制作用， 葡萄糖，L-山梨糖，2-脱氧-D-核糖和/或2-脱氧-L-核糖。 一种抑制血管内皮细胞管腔形成的方法，其特征在于利用D-阿洛糖，D-阿糖，D-古洛糖，D-塔洛糖，L-阿洛糖，2-脱氧-D-葡萄糖的血管内皮细胞管腔形成抑制作用 ，3-脱氧-D-葡萄糖，D-核糖，L-核糖，2-脱氧-D-核糖和/或2-脱氧-L-核糖。