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    MOLECULAR MARKER FOR EARLY INDENTIFICATION OF PLEURAL MESOTHELIOMA PATIENTS, AND EXPRESSION ANALYSIS METHOD FOR SAME
    2.
    发明公开
    MOLECULAR MARKER FOR EARLY INDENTIFICATION OF PLEURAL MESOTHELIOMA PATIENTS, AND EXPRESSION ANALYSIS METHOD FOR SAME 审中-公开
    MOLEKULARER MARKER ZURFRÜHENERKENNUNG VON PLEURAMESOTHELIOM-PATIENTEN UND EXPRESSIONSANALYSEVERFAHRENDAFÜR

    公开(公告)号：EP2757376A1

    公开(公告)日：2014-07-23

    申请号：EP12831729.4

    申请日：2012-09-14

    申请人： National University Corporation Nagoya University ,  Medical and Biological Laboratories Co., Ltd. ,  Oncomics Co., Ltd.

    发明人： YANAGISAWA, Kiyoshi ,  TAKAHASHI, Takashi ,  YOKOI, Kohei ,  HASEGAWA, Yoshinori ,  ONO, Ken-ichiro ,  YAGI, Kasumi ,  MASUDA, Hitomi ,  TAKEUCHI, Toshiyuki

    IPC分类号： G01N33/574 ,  C07K14/47 ,  C07K16/18 ,  C12N15/09

    CPC分类号： G01N33/57423 ,  C07K14/47 ,  C07K16/18 ,  G01N33/57407

    摘要： To develop a simple, low-cost and highly reliable testing method for mesothelioma, and a kit used for said testing method.
    The present invention provides a testing method for mesothelioma comprising a step in which the concentration of human periostin protein is measured in at least one type of sample from among samples of the blood or pleural fluid of a subject. The step in which the concentration of human periostin protein is measured may use an antibody directed against human periostin protein. The present invention further provides a kit for diagnosing mesothelioma, said kit including the antibody directed against human periostin protein. In one kit for diagnosing mesothelioma, the diagnosis of mesothelioma determines if a subject that may have mesothelioma has mesothelioma or is healthy. In another kit for diagnosing mesothelioma, the diagnosis of mesothelioma determines if a subject that may have mesothelioma has mesothelioma or has a respiratory illness other than mesothelioma.

    摘要翻译： 开发一种简单，低成本，高可靠性的间皮瘤检测方法，以及用于所述检测方法的试剂盒。 本发明提供了一种间皮瘤的检测方法，其特征在于，在受试者的血液或胸膜液样品中的至少一种样品中测定人骨膜素蛋白的浓度。 测量人骨膜素蛋白浓度的步骤可以使用针对人骨膜素蛋白的抗体。 本发明还提供了用于诊断间皮瘤的试剂盒，所述试剂盒包括针对人骨膜素蛋白的抗体。 在诊断间皮瘤的一个试剂盒中，间皮瘤的诊断决定了可能有间皮瘤的受试者是否具有间皮瘤或健康。 在诊断间皮瘤的另一个试剂盒中，间皮瘤的诊断决定了可能有间皮瘤的受试者是否具有间皮瘤或具有间皮瘤以外的呼吸系统疾病。

    ANTI-HUMAN CLCP1 ANTIBODY AND USE THEREOF
    4.
    发明公开
    ANTI-HUMAN CLCP1 ANTIBODY AND USE THEREOF 有权
    抗人CLCP1-ANTIKÖRPER在塞恩安汶

    公开(公告)号：EP2322610A1

    公开(公告)日：2011-05-18

    申请号：EP09797975.1

    申请日：2009-07-16

    申请人： Medical and Biological Laboratories Co., Ltd. ,  Oncomics Co., Ltd.

    发明人： ONO, Ken-ichiro ,  TAKAHASHI, Takashi

    IPC分类号： C12N15/09 ,  A61K39/395 ,  A61P35/00 ,  A61P35/04 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/08 ,  G01N33/15 ,  G01N33/50 ,  G01N33/574

    CPC分类号： G01N33/574 ,  A61K2039/505 ,  C07K16/3023 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/5011

    摘要： The present invention provides novel antibodies that recognize the extracellular domain of a human CLCP1 antigen; nucleic acids encoding the antibodies; vectors carrying the nucleic acids in an expressible manner; transformed cells containing the vectors; methods for producing the antibodies; diagnostic methods for cancer or prognosis of cancer, immunohistological or immunocytological assay methods, and kits for determining the expression level of CLCP1 in cells or tissues, all of which use the antibodies; pharmaceutical compositions comprising the antibodies; agents for treating or preventing CLCP1-expressing cancer; agents for inhibiting growth, migration, invasion, or metastasis of CLCP1-expressing cancer cells; immunostaining agents for staining CLCP1-expressing cancer cells; and agents for treating or preventing CLCP1-expressing tumor. The present invention also provides methods of screening for candidate substances that inhibit cancer cell growth, invasion, migration, or metastasis, or candidate substances having cytotoxicity against cancer cells.

    摘要翻译： 本发明提供识别人CLCP1抗原的细胞外结构域的新型抗体; 编码抗体的核酸; 以可表达的方式携带核​​酸的载体; 含有载体的转化细胞; 生产抗体的方法; 用于癌症或癌症预后的诊断方法，免疫组织化学或免疫细胞学测定方法，以及用于确定细胞或组织中所有使用抗体的CLCP1表达水平的试剂盒; 包含抗体的药物组合物; 用于治疗或预防表达CLCP1的癌症的药剂; 用于抑制表达CLCP1的癌细胞的生长，迁移，侵袭或转移的药剂; 用于染色表达CLCP1的癌细胞的免疫染色剂; 以及用于治疗或预防表达CLCP1的肿瘤的药剂。 本发明还提供筛选抑制癌细胞生长，侵袭，迁移或转移的候选物质或对癌细胞具有细胞毒性的候选物质的方法。