公开(公告)号：EP3791894A1

公开(公告)日：2021-03-17

申请号：EP19792052.3

申请日：2019-04-15

申请人： National University Corporation Okayama University ,  Niigata University ,  National University Corporation Gunma University ,  Kawasaki Gakuen Educational Foundation

发明人： SAKAGUCHI, Masakiyo ,  TOYOOKA, Shinichi ,  TOMIDA, Shuta ,  SHIEN, Kazuhiko ,  SATO, Hiroki ,  KINOSHITA, Rie ,  FUTAMI, Junichiro ,  ARAKI, Kota ,  OKAZAKI, Mikio ,  KONDO, Eisaku ,  INOUE, Yusuke ,  YAMAUCHI, Akira

IPC分类号： A61K39/395 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  C07K16/32 ,  C12N15/13

摘要： Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.