公开(公告)号：EP4450625A1

公开(公告)日：2024-10-23

申请号：EP22907455.4

申请日：2022-12-13

申请人： Nippon Shinyaku Co., Ltd. ,  Niigata University

发明人： KAWANO Takao ,  ODE Toshiaki ,  CHIBA Akie ,  ONODERA Osamu ,  KATO Taisuke ,  HIROKAWA Sachiko

IPC分类号： C12N15/113 ,  A61K31/7088 ,  A61K31/712 ,  A61K31/7125 ,  A61K48/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/28 ,  C07K14/47

摘要： The present invention provides an antisense oligonucleotide that is formed of 15-22 nucleotides and that is complementary to a nucleic acid including at least 15 consecutive bases in a specific target region of a base sequence of SEQ ID NO: 471, or a pharmaceutically acceptable salt thereof, or hydrates of those.

公开(公告)号：EP4205736A1

公开(公告)日：2023-07-05

申请号：EP22767147.6

申请日：2022-03-08

申请人： Niigata University ,  Denka Company Limited

发明人： SAITO, Akihiko ,  GOTO, Sawako ,  HIRAYAMA, Yoshiaki

IPC分类号： A61K31/201 ,  A61P13/12 ,  A61P43/00

摘要： One object of the present invention is to provide an inhibitor for renal injuries induced by a hemolytic reaction. In this invention, cilastatin or a pharmaceutically acceptable salt thereof is used.

公开(公告)号：EP3791894A1

公开(公告)日：2021-03-17

申请号：EP19792052.3

申请日：2019-04-15

申请人： National University Corporation Okayama University ,  Niigata University ,  National University Corporation Gunma University ,  Kawasaki Gakuen Educational Foundation

发明人： SAKAGUCHI, Masakiyo ,  TOYOOKA, Shinichi ,  TOMIDA, Shuta ,  SHIEN, Kazuhiko ,  SATO, Hiroki ,  KINOSHITA, Rie ,  FUTAMI, Junichiro ,  ARAKI, Kota ,  OKAZAKI, Mikio ,  KONDO, Eisaku ,  INOUE, Yusuke ,  YAMAUCHI, Akira

IPC分类号： A61K39/395 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  C07K16/32 ,  C12N15/13

摘要： Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.

公开(公告)号：EP3677683A1

公开(公告)日：2020-07-08

申请号：EP18850283.5

申请日：2018-08-31

申请人： Niigata University ,  Adeka Corporation

发明人： SATO Tsutomu ,  HOSHINO Tsutomu ,  TAKEHANA Toshihiko ,  KOIKE Seiji ,  SHIGENO Koichi

IPC分类号： C12N15/61 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N9/90 ,  C12P7/02

摘要： An object of the present invention is to provide a method for preparing ambrein, which can easily and efficiently obtain the ambrein.
The object can be solved by a mutated tetraprenyl-β-curcumene cyclase wherein (1) a 4th amino acid residue of a DXDD motif, aspartic acid, is substituted with an amino acid other than aspartic acid, and (2) an amino acid adjacent to the N-terminus of a (A/S/G)RX(H/N)XXP motif is substituted with an amino acid other than tyrosine, or a 4th amino acid of the GXGX(G/A/P) motif is substituted with an amino acid other than leucine.

公开(公告)号：EP3424502A1

公开(公告)日：2019-01-09

申请号：EP17760166.3

申请日：2017-03-03

申请人： Niigata University

发明人： NAKADA, Tsutomu ,  HUBER, Vincent ,  IGARASHI, Hironaka ,  SUZUKI, Yuji ,  KWEE, Ingrid

IPC分类号： A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4439 ,  A61P9/00 ,  A61P25/00 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00

摘要： An aquaporin 4 function promotor contains a compound represented by Formula (1) or (2) or a pharmaceutically acceptable salt thereof, as an active ingredient.

        NH 2 C(NH)NH(CH 2 ) n11 SO 3 H     (1)



(In the formula, n 11 represents an integer of 1 to 10, and R 21 represents one selected from the group consisting of an alkyl group having 1 to 10 carbon atoms, an alicyclic heterocyclic group, an aromatic hydrocarbon group, and an aromatic heterocyclic group.)

公开(公告)号：EP3267200A1

公开(公告)日：2018-01-10

申请号：EP16761673.9

申请日：2016-03-04

申请人： Niigata University ,  Eisai R&D Management Co., Ltd.

发明人： IKEUCHI Takeshi ,  KUWANO Ryozo ,  SATO Yoshiaki ,  BERNIER Francois

IPC分类号： G01N33/92 ,  G01N33/50

CPC分类号： G01N33/92 ,  G01N33/50 ,  G01N2800/2814 ,  G01N2800/52

摘要： Cholesterol and desmosterol levels, and the ratio of these levels can be used as a blood biomarker for Alzheimer's disease, frontotemporal lobar degeneration, or dementia with Lewy bodies.

摘要翻译： 胆固醇和去甾醇水平，并且这些水平的比率可以用作阿尔茨海默氏病，额颞叶变性或Lewy体痴呆的血液生物标志物。

公开(公告)号：EP2696200B1

公开(公告)日：2017-09-13

申请号：EP13191564.7

申请日：2010-04-27

申请人： Niigata University ,  Juntendo Educational Foundation ,  DENKA SEIKEN Co., Ltd.

发明人： Saito, Akihiko ,  Tomino, Yasuhiko ,  Asanuma, Katsuhiko ,  Ogasawara, Shinya ,  Kurosawa, Hiroyuki ,  Hirayama, Yoshiaki

IPC分类号： G01N33/53 ,  G01N33/543 ,  C07K14/47

CPC分类号： G01N33/92 ,  G01N2800/347

公开(公告)号：EP2537854B1

公开(公告)日：2016-12-14

申请号：EP11742224.6

申请日：2011-02-08

申请人： Tokyo Institute of Technology ,  Niigata University

发明人： TAKAHASHI, Takashi ,  TANAKA, Hiroshi ,  NAKADA, Tsutomu

IPC分类号： C07H5/02 ,  A61K51/00 ,  C07B59/00 ,  C07B61/00 ,  C08F236/20

CPC分类号： C07B59/00 ,  A61K51/0491 ,  C07H15/26 ,  C08F236/20

公开(公告)号：EP2738201A1

公开(公告)日：2014-06-04

申请号：EP12818446.2

申请日：2012-07-26

申请人： Niigata University ,  Sekisui Chemical Co., Ltd.

发明人： TANAKA Masato ,  OOMURA Takahiro

IPC分类号： C08J3/12 ,  B29B9/04

CPC分类号： B29B9/04 ,  B23K26/40 ,  B23K2203/16 ,  B23K2203/42 ,  B23K2203/50 ,  B29B2009/125

摘要： Provided is a method for producing fine particles in which fine particles having a uniform particle size distribution can be simply obtained with a low environmental load. The present invention relates to a method for producing fine particles including the step of preparing minute pieces by cutting a resin film at equal intervals into a width of 0.05 to 500 µm.

摘要翻译： 本发明提供能够以低环境负荷简单地获得具有均匀粒度分布的微粒的微粒的制造方法。 本发明涉及一种微粒的制造方法，其特征在于，包括通过以等间隔将树脂膜切割成0.05〜500μm的宽度来制造微小片的工序。

公开(公告)号：EP2696200A1

公开(公告)日：2014-02-12

申请号：EP13191564.7

申请日：2010-04-27

申请人： Niigata University ,  Juntendo Educational Foundation ,  DENKA SEIKEN Co., Ltd.

发明人： Saito, Akihiko ,  Tomino, Yasuhiko ,  Asanuma, Katsuhiko ,  Ogasawara, Shinya ,  Kurosawa, Hiroyuki ,  Hirayama, Yoshiaki

IPC分类号： G01N33/53 ,  G01N33/543 ,  C07K14/47

CPC分类号： G01N33/92 ,  G01N2800/347

摘要： The present invention relates to a detection kit and a detection marker used for diagnosing a renal disease. Also, the present invention relates to a method for diagnosing a renal disease using the megalin level in urine as an indicator for diagnosing a renal disorder in the form of a marker. In addition, the present invention relates to a method for evaluating effects of treating a renal disease.
In particular, this invention provides a method for detecting a renal disease comprising measuring a human megalin ectodomain fragment existing in urine, wherein the large amount of human megalin ectodomain fragment excreted into the urine indicates the renal disorder.

摘要翻译： 本发明涉及一种检测试剂盒和用于诊断肾病的检测标记物。 所以，本发明涉及一种用于使用在尿中的巨蛋白水平作为用于在标记物的形式诊断肾病症指示器诊断肾病的方法。 此外，本发明涉及一种用于评估治疗肾脏疾病的影响的方法。 特别地，本发明提供用于检测肾病包括测量存在于尿中的人巨蛋白的胞外域片段，worin大量排泄到尿中的人巨蛋白胞外结构域片段的方法表示所述肾病。