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公开(公告)号：EP4223871A1
公开(公告)日：2023-08-09
申请号：EP21875635.1
申请日：2021-09-28
申请人： National University Corporation Tokyo Medical and Dental University , Takeda Pharmaceutical Company Limited
发明人： TAKEBE Takanori , SAIKI Norikazu
摘要： The present invention provides means for producing a parathyroid gland organoid. A culture method of the present invention includes a cell population containing a parathyroid gland cell in a ratio of 50% or more, and a mesenchymal cell in a ratio of 10% or more; and a step of culturing the cell population.
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公开(公告)号：EP4332215A1
公开(公告)日：2024-03-06
申请号：EP22795832.9
申请日：2022-04-27
申请人： National University Corporation Tokyo Medical and Dental University , Takeda Pharmaceutical Company Limited
发明人： TAKEBE Takanori , SAIKI Norikazu
IPC分类号： C12N5/071 , C12N5/0735 , C12N5/10
摘要： An object of the present invention is to provide an ever-better method for producing sinusoidal endothelial cells. The present invention provides a method for producing sinusoidal endothelial cells from sinusoidal endothelial progenitor cells, the method comprising the step of culturing the sinusoidal endothelial progenitor cells in a medium containing one or more substances selected from the interleukin 6 (IL-6) family, for example, oncostatin M (OSM), interleukin 6 (IL-6), or interleukin 11 (IL-11).
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公开(公告)号：EP4306633A1
公开(公告)日：2024-01-17
申请号：EP22767125.2
申请日：2022-03-08
申请人： National University Corporation Tokyo Medical and Dental University , Takeda Pharmaceutical Company Limited
发明人： TAKEBE Takanori , SAIKI Norikazu
摘要： The present invention provides the following method as an approach for enriching desired cells, particularly, yolk sac mesoderm cells or amniotic ectoderm cells, contained in an embryogenesis region-specific micropattern structure of a cell cluster formed by differentiation-inducing factors from a colony of pluripotent stem cells such as iPS cells: a method for producing a cell cluster enriched in desired cells from pluripotent stem cells, comprising the step of two-dimensionally culturing the pluripotent stem cells under Wnt signal regulation. The present invention provides, for example, a method for producing a cell cluster enriched in yolk sac mesoderm cells from pluripotent stem cells, comprising the step of two-dimensionally culturing the pluripotent stem cells under conditions that activate Wnt signals, and a method for producing a cell cluster enriched in amniotic ectoderm cells from pluripotent stem cells, comprising the step of two-dimensionally culturing the pluripotent stem cells under conditions where Wnt signals have been suppressed.
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公开(公告)号：EP3949730A1
公开(公告)日：2022-02-09
申请号：EP20783389.8
申请日：2020-03-27
发明人： TAKEBE Takanori , SAIKI Norikazu
IPC分类号： A01K67/027 , C12M1/00 , C12M3/00 , C12N5/071 , C12P21/02
摘要： The present invention provides means for producing an organoid close to an organ in a living body and capable of secretion of a plasma protein and immune response. A matrix composition of the present invention provided as such means includes: (1) a first matrix containing one or more cells selected from the group consisting of vascular cells, nerve cells, and blood cells; and (2) a second matrix containing cells constituting an organ and/or an organoid, in which the first matrix envelops the second matrix, and the first matrix has at least one opening.
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公开(公告)号：EP3932486A1
公开(公告)日：2022-01-05
申请号：EP20762621.9
申请日：2020-02-27
发明人： TAKEBE Takanori , SAIKI Norikazu , KAWAKAMI Eri
摘要： The present invention provides a composition suitable as a composition for treating blood coagulation and/or complement disorders (raw materials for producing therapeutic agents for these diseases) and a method for effectively producing the composition. A method for producing a composition for treating blood coagulation and/or complement disorders according to the present invention includes the following steps of: (1) embedding an organoid formed from vascular endothelial cells or vascular endothelial cells and hepatocytes, in an extracellular matrix; (2) culturing the extracellular matrix; and (3) collecting a culture supernatant from the culture obtained in the step (2).
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