公开(公告)号：EP4026911A1

公开(公告)日：2022-07-13

申请号：EP20861179.8

申请日：2020-09-04

申请人： National University Corporation Tokyo University Of Agriculture and Technology ,  Peptide Support Co. Ltd.

发明人： MATSUDA, Hiroshi ,  NISHINO, Norikazu

IPC分类号： C12Q1/37

摘要： An object of the present invention is to provide a method for measuring tryptase activity in a blood sample accurately and rapidly by a convenient operation in order to accurately evaluate the state of a disease whose state involves mast cells. The present invention enables tryptase activity in a blood sample to be directly measured without the pretreatment, such as purification or concentration, of the blood sample, using a substrate for measuring tryptase activity, comprising a tripeptide C-terminally linked through a peptide bond to a dye label, selected from the following formulas (1) to (3): (1) Lys-Ala-Arg-X, (2) Ala-Ala-Arg-X, and (3) Abu-Ala-Arg-X (wherein X represents a dye label whose fluorescence characteristics or color development characteristics change upon the cleavage of the peptide bond with Arg, and Abu represents 2-aminobutyric acid) .

公开(公告)号：EP2913062B1

公开(公告)日：2019-05-08

申请号：EP13848627.9

申请日：2013-10-24

申请人： Japan Innovative Therapeutics, Inc. ,  National University Corporation Tokyo University of Agriculture and Technology

发明人： MATSUDA, Hiroshi ,  TANAKA, Akane

IPC分类号： A61K45/00 ,  A61P27/02 ,  G01N33/15 ,  G01N33/50 ,  G01N33/68 ,  A61K31/352 ,  A61K31/245 ,  A61K45/06 ,  A61K47/10 ,  A61K9/00 ,  C07K16/40 ,  G01N33/573